Sandwich ELISA, HRP-labelled antibody
Serum, Plasma, Cell culture supernatant
At ambient temperature. Upon receipt, store the product at the temperature recommended below.
Limit of Detection
CV = 4.0%
CV = 6.8%
Apoptosis, Cardiovascular disease, Cell surface proteins (sCD), Cytokines and chemokines and related molecules, Transplantation
CD40 belongs to the TNF receptor superfamily. A key role of CD40/CD40ligand interactions in immune activation, particularly in T-cell dependent B cell responses is anticipated. This molecule as well as the other ligands of the family share the property of co-stimulation of T-cell proliferation and are all expressed by activated T-cells.Because the ligand of CD40 (CD40L) is expressed on activated T helper cells, B cells may escape from apoptosis and are activated when the immune system interacts with foreign antigens, which are normally able to activate T-helper cells. Thus the CD40/CD40L interaction plays a central role in the various phases of the B cell response to T-dependent antigens.