sST2 (Soluble suppression of tumorigenicity 2) is a member of the interleukin-1 receptor family. Like other members of the IL-1 family, the binding of IL-33 to its transmembrane receptor ST2L on the surface of inflammatory cells activates intracellular signaling pathways and mediates pro-inflammatory effects. The soluble ST2 isoform is released by activated Th2 cells and stressed cardiac myocytes and is elevated in the serum of patients with allergic asthma. Soluble ST2 acts as a decoy receptor, blocking IL‑33’s ability to signal through the transmembrane ST2 receptor. sST2 is a strong predictor of disease severity and mortality in cardiovascular disease and serves as a reliable predictor of mortality in patients with stable coronary artery disease and chronic heart failure.
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