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Thioredoxin (Trx)

Thioredoxins (Trx) are small, multi-functional proteins with oxidoreductase activity and are ubiquitous in essentially all living cells. Trx contains a redox-active disulfide/ dithiol group within the conserved Cys-Gly-Pro-Cys active site. The two cysteine residues in the conserved active centers can be oxidized to form intramolecular disulfide bonds. Reduction of the active site disulfide in oxidized Trx is catalyzed by Trx reductase with NADPH as the electron donor. The reduced Trx is a hydrogen donor for ribonucleotide reductase, the essential enzyme for DNA synthesis, and a potent general protein disulfide reductase with numerous functions in growth and redox regulations. Specific protein disulfide targets for reduction by Trx include protein disulfide –isomerase (PDI) and a number of transcription factors such as p53, NFkB and AP-1 (T1–151). Trx is also capable of removing H2O2, particularly when it is coupled with either methionine sulfoxide reductase or several isoforms of peroxiredoxins.

1 result found in Immunoassays
4 results found in Proteins
4 results found in Antibodies

Immunoassays
Product Size Price
Thioredoxin 1 Human ELISA

Type: Sandwich ELISA, Biotin-labelled antibody

RLF-EK0125R 96 wells (1 kit)
 
Proteins
Product Size Price
Thioredoxin 1 Human (E.coli)

LF-P0001 10 U
 
Thioredoxin 1 Yeast (E.coli)

LF-P0036 10 U
 
Thioredoxin 2 Human (E.coli)

Type: Recombinant

LF-P0006 1 U
 
Thioredoxin 2 Yeast (E.coli)

LF-P0052 10 U
 
Antibodies
Product Size Price
Thioredoxin 1 Human, Mouse Monoclonal Antibody, Clone: 3A1

Type: Monoclonal Antibody

LF-MA0055 100 ul
 
Thioredoxin 1 Human, Mouse Monoclonal Antibody, Clone: 8A1

Type: Monoclonal Antibody

LF-MA0077 100 ul
 
Thioredoxin 2 Human, Mouse Monoclonal Antibody, Clone: 4C5

Type: Monoclonal Antibody

LF-MA0079 100 ul
 
Thioredoxin 2 Human, Mouse Monoclonal Antibody, Clone: 71G4

Type: Monoclonal Antibody

LF-MA0080 100 ul