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TRAP 5 (TRACP 5, Tartrate Resistant Acid Phosphatase 5)

TRAP 5 (serum band 5 tartrate-resistant acid phosphatase, TRACP 5; EC is a glycoprotein of 35–37 kDa. TRAP 5 belongs to the most abundant enzymes in osteoclasts. It is expressed in certain differentiated cells of the mononuclear phagocyte system, particularly osteoclasts and alveolar macrophages, where it takes an active part in bone resorption process. High blood levels of TRAP 5 are usually associated with active bone remodelling. Increased serum levels are observed during normal bone growth among healthy children. Elevated serum TRAP levels have been detected in diseases characterized by increased bone resorption; Paget’s disease of the bone, hemodialysis, primary hyperparathyro­idism, metastatic malignancies involving bone resorption, multiple myeloma and bilaterally ovariectomized women. Post-menopausal women have higher levels of serum than post-menopausal women on estrogen replacement therapy. Therefore specific determination of TRAP 5 activity can be essential for clinical assessment of bone metabolism.

2 results found in Immunoassays
1 result found in Antibodies

Product Size Price
MouseTRAP Assay (TRACP 5b mouse) ELISA

Type: Immunocapture enzyme activity assay

SB-TR103 96 wells $860
RatTRAP Assay (TRACP 5b rat) ELISA

Type: Immunocapture enzyme activity assay

SB-TR102 96 wells $860