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ULBP5 (Retinoic acid early transcript 1G protein, RAET1G)

ULBP5 acts as a ligand for the NKG2D receptor on the surface of NK cells. ULBP ligands are produced by virally infected cells and tumours. Stimulation of NKG2D contributes to anti-tumour and anti-viral immune responses of NK cells. ULBP5 is expressed in two variants, as a membrane and soluble isoform.

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