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VAP-1 (Vascular adhesion protein 1, copper-containing 3 , Voltage-dependent anion channel, VDAC)

The mature VAP-1 molecule is a 170 kDa homodimeric glycoprotein that consists of two 90 kDa subunits held together by disulfide bonds. VAP-1 has a large extracellular domain, a single-pass transmembrane domain, and a short cytoplasmic tail. The molecule has abundant sialic acid decorations that are essential to its adhesive function, because VAP-1 is unable to mediate lymphocyte adhesion to desialylated vessels. The leukocyte ligand for VAP-1 is currently unknown. Induction of VAP-1 has been shown at sites of inflam-mation, such as in inflammatory bowel diseases and chronic dermatoses, where expression of VAP-1 is clearly increased. It is constitutively expressed on hepatic endothelium playing a critical role in regulation of T-cell recirculation to the liver. Strong expression of VAP-1 on tumor endothelium distinguishes human hepatocellular carcinomas from colorectal hepatic metastases.

1 result found in Immunoassays
3 results found in Proteins
1 result found in Antibodies

Immunoassays
Product Size Price
sVAP-1 Human ELISA

Type: Sandwich ELISA, Biotin-labelled antibody

RAF117R 96 wells (1 kit)
 
Proteins
Product Size Price
VAP-1 Human Chinese Hamster Ovary Cells (CHO)

Type: Recombinant

RBG10338002 2 µg
RBG10338010 10 µg
RBG10338100 100 μg
 
Antibodies
Product Size Price
VDAC1 Human, Rabbit Polyclonal Antibody

Type: Polyclonal Antibody

LF-PA0155 100 ul