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Xylosyltransferase 2 (Peptide O-xylosyltransferase 1, Xylosyltransferase II, XT-II, XylT-II, UDP-D-xylose:proteoglycan core protein beta-D-xylosyltransferase)

Xylosyltransferases (XTs) are ubiquitously expressed enzymes that belong to the group of glycosyltransfe­rases. These enzymes initiate the proteoglycans formation by assembly of glycosaminoglycan (GAG) chains to the protein substrate by catalysing the transfer of xylose from the nucleoside diphosphate donor (UDP-xylose) to serine residues in the protein [1, 2]. XTs reside in the endoplasmatic reticulum and/or cis-Golgi, but they are also released into extracellular matrix [3]. The XTs serum activity has been proposed as biomarker of altered proteoglycan metabolism in various diseases, eg. diabetes, systematic sclerosis, liver neoplasia and HTLV-1 retrovirus adhesion [4].

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