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Zinc Transporter 8 Autoantibody (ZnT8 Ab)

The BioVendor Zinc Transporter 8 autoantibody (ZnT8 Ab) ELISA kit is intended for use by professional persons only, for the quantitative determination of ZnT8 Ab in human serum. Autoantibodies to pancreatic beta cell antigens are important serological markers of type 1 diabetes mellitus (type 1 DM). The antigens recognised by these antibodies include insulin, glutamic acid decarboxylase (GAD65 kDa isoform), the islet cell antigen IA-2 or ICA-512 and zinc transporter 8 (ZnT8). ZnT8 Ab are directed principally to the C terminal domain of ZnT8 (residues 268 – 369). Human population gene polymorphism at the codon for the 325th amino acid results in the expression of three protein variants: Arginine ® 325, Tryptophan (W) 325 and very rarely Glutamine (Q) 325. ZnT8 Ab may be specific to the R 325 or W 325 variant, or may be residue 325 non-specific. Sera that react with the Q allele only are extremely rare. BioVendor’s ZnT8 Ab ELISA is capable of detecting, and quantifying, autoantibodies specific to R 325 or to W 325, or to residue 325 non-specific variants.

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