Cat # changed from REA212/96R to EA212/96
Competitive ELISA, Immobilized antigen
20 µl patient serum or plasma
At ambient temperature. Upon receipt, store the product at the temperature recommended below.
Store the complete kit at 2–8°C. Under these conditions, the kit is stable until the expiration date (see label on the box).
0.2 µmol/l – 3.0 µmol/l
Limit of Detection
4.9 – 5.4 %
4.3 – 9.6 %
Blood pressure regulation and NO metabolism, Cardiovascular disease
The vascular endothelium plays a central role in the regulation of vascular structure and function, mainly due to the formation of endothelium-derived nitric oxide (NO). NO is formed by the enzyme NO synthetase (NOS) from the amino acid precursor L-arginine. NOS activity can be downregulated by ADMA, an endogenous inhibitor of NOS. Elevated ADMA levels in plasma have been found in clinical studies including patients with hypercholesterolemia, hypertension, chronic heart failure, chronic renal failure and other internal disorders. ADMA may have diagnostic relevance as a novel cardiovascular risk marker.