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Amyloid beta (Aß, A beta)

Amyloid beta (Aβ or A beta) is a protein fragment of 39–43 amino acids that is the main constituent of amyloid plaques in the brains of Alzheimer's disease patients. Aβ is formed after sequential cleavage of the amyloid precursor protein (APP, transmembrane glycoprotein) by the β- and γ-secretases. . The major species generated are Aβ40 and Aβ42. The latter is more hydrophobic and more apt to aggregate and thus is considered to be primarily pathogenic, consistent with the phenotype of the major familial ADcausing mutations. Increases in either total Aβ levels or the relative concentration of the 42-amino acid form have been implicated in the pathogenesis of both familial and sporadic Alzheimer's di­sease. The 42-mers are the most amyloidogenic form of the peptide.

4 results found in Immunoassays

Immunoassays
Product Size Price
Human Amyloid beta (Aggregated) ELISA

Type: Sandwich ELISA, HRP-labelled antibody

New RIG018R 96 wells (1 kit)
 
Human Amyloid beta 42 ELISA, Ultrasensitive

Type: Sandwich ELISA, HRP-labelled antibody

New RIG017R 96 wells (1 kit)
 
Mouse Amyloid beta 40 ELISA

Type: Sandwich ELISA, HRP-labelled antibody

New RIG013R 96 wells (1 kit)
 
Mouse Amyloid beta 42 ELISA

Type: Sandwich ELISA, HRP-labelled antibody

New RIG012R 96 wells (1 kit)