Human Apolipoprotein M (ApoM, protein G3a, NG20-like protein NG20), is a protein that in humans is encoded by the APOM gene. Two different isoforms have been found for this gene. ApoM is a secreted 25kDa member of the lipocalin protein family consisting of 188 amino acids. Human APOM shares sequence identity with pig (91%) and mouse (80%) APOM. The apolipoproteins are a structurally-unrelated group of proteins that all have some role in the transport of lipids in blood. Apolipoproteins plus phospholipids, cholesterol and triglycerides, form spherical particles with a lipid/hydrophobic center and a (apolipo)protein coat. The apolipoprotein coat promotes aqueous solubility and serves as a ligand for lipoprotein receptors. HDL may contain apoliporoteins A,C, D,E, J, L and M, while LDL contains apolipoproteins B and E. Areas of investigation: Lipoprotein metabolism, Obesity, Atherosclerosis, Diabetes mellitus, Immune Response, Infection and Inflammation.