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Beta2-Microglobulin Human ELISA

  • Regulatory status:RUO
  • Type:Competitive ELISA, Immobilized antigen
  • Species:Human
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Cat. No. Size Price


RCD003R 96 wells (1 kit)
PubMed Product Details
Technical Data

Type

Competitive ELISA, Immobilized antigen

Applications

Serum

Sample Requirements

20 µl/well

Storage/Expiration

Store the complete kit at 2–8°C. Under these conditions, the kit is stable until the expiration date (see label on the box).

Calibration Curve

Calibration Range

0.2–10 mg/l

Limit of Detection

0.1 mg/l

Summary

Research topic

Oncology, Renal disease

Summary

ß2-microglobulin occurs in blood, urine, and body fluids. It has been reported that its concentration in blood varies in humans under pathological conditions such as glomerular disturbances, autoimmune diseases, malignant tumors and hepatic disturbances, while its concentration in urine is subject to changes by urethral disturbances and by the changes in its concentration in blood.

References to Summary

References to Beta2-Microglobulin

  • Bhalla RB, Safai B, Mertelsmann R, Schwartz MK. Abnormally high concentrations of beta 2 microglobulin in acquired immunodeficiency syndrome (AIDS) patients. Clin Chem. 1983 Aug;29 (8):1560
  • Brodsky FM, Bodmer WF, Parham P. Characterization of a monoclonal anti-beta 2-microglobulin antibody and its use in the genetic and biochemical analysis of major histocompatibility antigens. Eur J Immunol. 1979 Jul;9 (7):536-45
  • Burnett RW. Accurate estimation of standard deviations for quantitative methods used in clinical chemistry. Clin Chem. 1975 Dec;21 (13):1935-8
  • Check JH, Ubelacker L, Lauer CC. Falsely elevated steroidal assay levels related to heterophile antibodies against various animal species. Gynecol Obstet Invest. 1995;40 (2):139-40
  • Check JH, Ubelacker L, Lauer CC. Falsely elevated steroidal assay levels related to heterophile antibodies against various animal species. Gynecol Obstet Invest. 1995;40 (2):139-40
  • Domingo P, Martinez E, Martinez C, Fuster M, Cortes M, Sambeat MA, Ris J, Cadafalch J. Prognostic value of serum beta 2-microglobulin in HIV infection. Lancet. 1992 Aug 8;340 (8815):371-2
  • Evrin PE, Jansson NO, Bergdahl A. A turbidimetric immunochemical method for determination of serum beta 2-microglobulin using a centrifugal analyzer. Clin Chim Acta. 1986 Mar 16;155 (2):151-7
  • Fahey JL, Taylor JM, Detels R, Hofmann B, Melmed R, Nishanian P, Giorgi JV. The prognostic value of cellular and serologic markers in infection with human immunodeficiency virus type 1. N Engl J Med. 1990 Jan 18;322 (3):166-72
  • Francioli P, Clement F, Vaudois CH. Beta 2-microglobulin and immunodeficiency in a homosexual man. N Engl J Med. 1982 Nov 25;307 (22):1402-3
  • Lacey JN, Forbes MA, Waugh MA, Cooper EH, Hambling MH. Serum beta 2-microglobulin and human immunodeficiency virus infection. AIDS. 1987 Jul;1 (2):123-7
  • LeClair K, Van Agthoven A, Terhorst C. A rapid method for isolation of antigenically active human cell surface antigens associated with beta 2-microglobulin using a monoclonal antibody. J Immunol Methods. 1981;41 (2):137-44
  • Ling TG, Mattiasson B. A general study of the binding and separation in partition affinity ligand assay. Immunoassay of beta 2-microglobulin. J Immunol Methods. 1983 May 13;59 (3):327-37
  • Nilsson K, Evrin PE, Berggard I, Ponten J. Involvement of lymphoid and nonlymphoid cells in the production of beta2-microglobulin-a homologue of the constant domains of IgG. Nat New Biol. 1973 Jul 11;244 (132):44-5
  • O'Reilly D, Whicher J, Sanderson AR. A simple, precise and sensitive nephelometric assay for beta 2-microglobulin in body fluids. J Immunol Methods. 1983 Feb 25;57 (1-3):265-73
  • Sonnerborg AB, von Stedingk LV, Hansson LO, Strannegard OO. Elevated neopterin and beta 2-microglobulin levels in blood and cerebrospinal fluid occur early in HIV-1 infection. AIDS. 1989 May;3 (5):277-83
  • Tachibana K, Tanaka E, Usuda S, Okamoto H, Imai M, Nakamura T, Miyakawa Y, Mayumi M. A two-site sandwich radioimmunoassay of beta 2-microglobulin with monoclonal antibodies. J Immunol Methods. 1984 Dec 14;75 (1):43-51
  • Uotila M, Ruoslahti E, Engvall E. Two-site sandwich enzyme immunoassay with monoclonal antibodies to human alpha-fetoprotein. J Immunol Methods. 1981;42 (1):11-5
  • Wibell L, Evrin PE, Berggard I. Serum 2 -microglobulin in renal disease. Nephron. 1973;10 (5):320-31
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