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Chorionic Gonadotropin Human

  • Regulatory status:RUO
  • Type:Native protein
  • Source:Urine of pregnant women
  • Other names:hCG
  • Species:Human
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Cat. No. Size Price


New RP17825010 10 mg
New RP17825005 5 mg
PubMed Product Details
Technical Data

Type

Native protein

Description

Human Chorionic Gonadotropin is produced from a sterile preparation of placental glucoprotein urine of pregnant women having a total molecular mass of 36,700 Dalton. The hCG consists of 237 amino acids, a chain-92 amino acids and b chain-145 amino acids. The hCG is purified by proprietary chromatographic techniques.

Source

Urine of pregnant women

Biological Activity

The activity was found to be 5625 IU/mg.

Formulation

The hCG was lyophilized with no additives.

Physical Appearance

Sterile filtered white lyophilized (freeze-dried) powder.

Summary

Research topic

Reproduction

Summary

Human chorionic gonadotropin (hCG) is a peptide hormone produced in pregnancy, that is made by the embryosoon after conception and later by the syncytiotrophoblast (part of the placenta). Its role is to prevent the disintegration of the corpus luteum of the ovary and thereby maintain progesterone production that is critical for a pregnancy in humans. hCG may have additional functions, for instance it is thought that it affects the immune tolerance of the pregnancy. Early pregnancy testing generally is based on the detection or measurement of hCG.

References to Summary

References to Chorionic Gonadotropin

  • Bindra R, Heath V, Liao A, Spencer K, Nicolaides KH. One-stop clinic for assessment of risk for trisomy 21 at 11-14 weeks: a prospective study of 15 030 pregnancies. Ultrasound Obstet Gynecol. 2002 Sep;20 (3):219-25
  • Braunstein GD, Rasor J, Danzer H, Adler D, Wade ME. Serum human chorionic gonadotropin levels throughout normal pregnancy. Am J Obstet Gynecol. 1976 Nov 15;126 (6):678-81
  • Breimer L. First trimester biochemical screening for trisomy 21: the role of free beta-hCG and pregnancy associated plasma protein. Ann Clin Biochem. 1995 Mar;32 ( Pt 2):233
  • Brizot ML, Jauniaux E, Mckie AT, Farzaneh F, Nicolaides KH. Placental expression of alpha and beta subunits of human chorionic gonadotrophin in early pregnancies with Down's syndrome. Hum Reprod. 1995 Sep;10 (9):2506-9
  • Chandler HM, Hurrell JG. A new enzyme immunoassay system suitable for field use and its application in a snake venom detection kit. Clin Chim Acta. 1982 May 20;121 (2):225-30
  • Chen R, Weng L, Sizto NC, Osorio B, Hsu CJ, Rodgers R, Litman DJ. Ultrasound-accelerated immunoassay, as exemplified by enzyme immunoassay of choriogonadotropin. Clin Chem. 1984 Sep;30 (9):1446-51
  • Cole LA, Hartle RJ, Laferla JJ, Ruddon RW. Detection of the free beta subunit of human chorionic gonadotropin (HCG) in cultures of normal and malignant trophoblast cells, pregnancy sera, and sera of patients with choriocarcinoma. Endocrinology. 1983 Sep;113 (3):1176-8
  • Densem J, Wald NJ. Down's syndrome screening: value of using free beta-hCG. Prenat Diagn. 1995 Jan;15 (1):94-5
  • Forest JC, Masse J, Rousseau F, Moutquin JM, Brideau NA, Belanger M. Screening for Down syndrome during the first and second trimesters: impact of risk estimation parameters. Clin Biochem. 1995 Aug;28 (4):443-9
  • Gaspard UJ, Reuter AM, Deville JL, Vrindts-Gevaert Y, Bagshawe KD, Franchimont P. Serum concentration of human chorionic gonadotropin and its alpha and beta subunits. 2. Trophoblastic tumours. Clin Endocrinol (Oxf). 1980 Oct;13 (4):319-29
  • Hay DL. Placental histology and the production of human choriogonadotrophin and its subunits in pregnancy. Br J Obstet Gynaecol. 1988 Dec;95 (12):1268-75
  • Loncar J, Barnabei VM, Larsen JW Jr. Advent of maternal serum markers for Down syndrome screening. Obstet Gynecol Surv. 1995 Apr;50 (4):316-20
  • Macri JN, Kasturi RV, Krantz DA, Cook EJ, Moore ND, Young JA, Romero K, Larsen JW Jr. Maternal serum Down syndrome screening: free beta-protein is a more effective marker than human chorionic gonadotropin. Am J Obstet Gynecol. 1990 Oct;163 (4 Pt 1):1248-53
  • Macri JN, Kasturi RV, Krantz DA, Cook EJ, Moore ND, Young JA, Romero K, Larsen JW Jr. Maternal serum Down syndrome screening: free beta-protein is a more effective marker than human chorionic gonadotropin. Am J Obstet Gynecol. 1990 Oct;163 (4 Pt 1):1248-53
  • Milwidsky A, Adoni A, Miodovnik M, Segal S, Palti Z. Human chorionic gonadotropin (beta-subunit) in the early diagnosis of ectopic pregnancy. Obstet Gynecol. 1978 Jun;51 (6):725-6
  • Miyachi Y, Vaitukaitis JL, Nieschlag E, Lipsett MB. Enzymatic radioiodination of gonadotropins. J Clin Endocrinol Metab. 1972 Jan;34 (1):23-8
  • Ozturk M, Berkowitz R, Goldstein D, Bellet D, Wands JR. Differential production of human chorionic gonadotropin and free subunits in gestational trophoblastic disease. Am J Obstet Gynecol. 1988 Jan;158 (1):193-8
  • Simpson ER, MacDonald PC. Endocrine physiology of the placenta. Annu Rev Physiol. 1981;43:163-88
  • Spencer K. Evaluation of an assay of the free beta-subunit of choriogonadotropin and its potential value in screening for Down's syndrome. Clin Chem. 1991 Jun;37 (6):809-14
  • Spencer K, Macri JN. Early detection of Down's syndrome using free beta human choriogonadotropin. Ann Clin Biochem. 1992 May;29 ( Pt 3):349-50
  • Uotila M, Ruoslahti E, Engvall E. Two-site sandwich enzyme immunoassay with monoclonal antibodies to human alpha-fetoprotein. J Immunol Methods. 1981;42 (1):11-5
  • Vaitukaitis JL, Braunstein GD, Ro
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