Plasma fibronectin level is elevated in severe coronary artery disease. Increased plasma fibronectin levels are related with venous thromboembolism (VTE) particularly in males, and extend the probable association between biomarkers and risk factors for arterial atherothrombosis and VTE. Fibronectin plays a role in several cellular processes, including tissue repair, embryogenesis, blood clotting, and cell migration/adhesion. Fibronectin consists in two main forms: 1) as an insoluble glycoprotein dimer that serves as a linker in the etracellular matrix and 2) as a soluble disulphide linked dimer found in the plasma. The plasma form is produced by hepatocytes, and the ECM form is synthesized by fibroblasts, chondrocytes, endothelial cells, macrophages, as well as certain epithelial cells. Fibronectin alos takes part as a general cell adhesion molecule by anchoring cells to collagen or proteoglycan substrates. Fibronectin organizes cellular interaction with the ECM by binding to different components of the extracellular matrix and to membrane-bound Fibronectin receptors on cell surfaces.
Greater than 95.0% as determined by analysis by SDS-PAGE.
The Fibronectin was lyophilized from a concentrated 1mg/ml solution containing 0.05M Tris HCl pH-7.5 and 0.1M NaCl.
At ambient temperature. Upon receipt, store the product at the temperature recommended below.
Lyophilized Fibronectin although stable at room temperature for 1 week, should be stored desiccated below –18°C. Upon reconstitution Fibronectin should be stored at 4°C between 2–7 days and for future use below –18°C. Please prevent freeze-thaw cycles.
Sterile filtered white lyophilized (freeze-dried) powder.