Select country change
Shopping cart (0 , 0,00 ) Menu Search
Manufactured by BioVendor

Growth Hormone Human ELISA

  • Regulatory status:RUO
  • Type:Sandwich ELISA, HRP-labelled antibody
  • Other names:GH
  • Species:Human
Please select your region to see available products and prices.
Cat. No. Size Price


RCD017R 96 wells (1 kit)
PubMed Product Details
Technical Data

Type

Sandwich ELISA, HRP-labelled antibody

Applications

Serum

Sample Requirements

25 µl/well

Storage/Expiration

Store the complete kit at 2–8°C. Under these conditions, the kit is stable until the expiration date (see label on the box).

Calibration Curve

Calibration Range

1–50 ng/ml

Limit of Detection

0.2 ng/ml

Summary

Research topic

Growth hormone and factor-related products

Summary

Human growth hormone (hGH) is a polypeptide of 191 amino acids secreted by the somatroph cells of the anterior pituitary. Growth hormone is principally a regulator of body growth and its metabolic effects are primarily anabolic. Some of its effects include promotion of protein conservation through its involvement in a wide range of protein synthesis mechanisms, enhancement of glucose transport and facilitation of glycogen storage. In addition, it induces the release of somatomedins (insulin-like growth factors), which further mediate the cascade of growth promoting actions.
Measurement of hGH is primarily of interest in the diagnosis and treatment of various forms of decreased secretion of hGH. Hyposecretion of hGH in children results in growth retardation and hypersecretion leads to gigantism in children and acromegaly in adults.
The secretion of hGH varies throughout the day under the influence of intricate neurogenic, metabolic and hormonal control. Due to the pulsatile nature of hGH release, it is often inaccurate to define a reference range and status based on single serum measurements. To diagnose disorders of hGH secretion more reliably, dynamic tests are used in which serum hGH levels are measured over a period following suppression or stimulation of hGH secretion.

References to Summary

References to Growth Hormone

  • Beck P, Schalch DS, Parker ML, Kipnis DM, Daughaday WH. Correlative studies of growth hormone and insulin plasma concentrations with metabolic abnormalities in acromegaly. J Lab Clin Med. 1965 Sep;66 (3):366-79
  • Camanni F, Massara F, Belforte L, Rosatello A, Molinatti GM. Effect of dopamine on plasma growth hormone and prolactin levels in normal and acromegalic subjects. J Clin Endocrinol Metab. 1977 Mar;44 (3):465-73
  • Celniker AC, Chen AB, Wert RM Jr, Sherman BM. Variability in the quantitation of circulating growth hormone using commercial immunoassays. J Clin Endocrinol Metab. 1989 Feb;68 (2):469-76
  • Crowley S, Hindmarsh PC, Matthews DR, Brook CG. Growth and the growth hormone axis in prepubertal children with asthma. J Pediatr. 1995 Feb;126 (2):297-303
  • Daughaday WH. The adenohypophysis In: "Textbook of Endocrinology", R.H. Williams ed., W.B. Saunders. 1981;Philadelphia, p;73
  • Daughaday WH, Cryer PE. Growth hormone hypersecretion and acromegaly. Hosp Pract. 1978 Aug;13 (8):75-80
  • Drobny EC, Amburn K, Baumann G. Circadian variation of basal plasma growth hormone in man. J Clin Endocrinol Metab. 1983 Sep;57 (3):524-8
  • Eddy RL, Gilliland PF, Ibarra JD Jr, McMurry JF Jr, Thompson JQ. Human growth hormone release. Comparison of provocative test procedures. Am J Med. 1974 Feb;56 (2):179-85
  • Frasier SD. A preview of growth hormone stimulation tests in children. Pediatrics. 1974 Jun;53 (6):929-37
  • Goldfine ID. Medical treatment of acromegaly. Annu Rev Med. 1978;29:407-15
  • Hashida S, Nakagawa K, Ishikawa E, Ohtaki S. Basal level of human growth hormone (hGH) in normal serum. Clin Chim Acta. 1985 Sep 30;151 (2):185-6
  • Kelly JJ, Rajkovic IA, O'Sullivan AJ, Sernia C, Ho KK. Effects of different oral oestrogen formulations on insulin-like growth factor-I, growth hormone and growth hormone binding protein in post-menopausal women. Clin Endocrinol (Oxf). 1993 Nov;39 (5):561-7
  • Lewis UJ, Singh RN, Tutwiler GF, Sigel MB, VanderLaan EF, VanderLaan WP. Human growth hormone: a complex of proteins. Recent Prog Horm Res. 1980;36:477-508
  • LI CH. Human growth hormone: perspective on its chemistry and physiology. In: "Advances in human growth hormone research", S. Raiti ed. U.S. Department of Health, Education and Welfare Publ. DMEW publ. no. (NJH). 74-612, p. 321;
  • Reutens AT, Hoffman DM, Leung KC, Ho KK. Evaluation and application of a highly sensitive assay for serum growth hormone (GH) in the study of adult GH deficiency. J Clin Endocrinol Metab. 1995 Feb;80 (2):480-5
Related Products Documents