Type
Sandwich ELISA
Applications
Plasma-EDTA, Urine
Sample Requirements
50 µl/well
Shipping
Shipped on blue ice packs. Upon receipt, store the product at the temperature recommended below.
Storage/Expiration
Store the complete kit at 2–8°C. Under these conditions, all components are stable until the expiration date (see label on the box).
Calibration Range
50 - 2000 pg/ml
Limit of Detection
25 pg/ml
Intra-assay (Within-Run)
n = 8
CV = 4.8%
Inter-assay (Run-to-Run)
n = 8
CV = 9.2%
Spiking Recovery
88.0%
Dilution Linearity
107.3%
Features
It is intended for research use only
The total assay time is less than 20 hours
The kit measures FGF-23
Assay format is 96 wells
Quality Controls are human serum based
Standard is a recombinant protein
Components of the kit are provided ready to use, concentrated or dried
Research topic
Bone and cartilage metabolism, Renal disease
Summary
Fibroblast growth factor-23 (FGF-23) is a phosphaturic hormone involved in mineral bone metabolism that helps control phosphate homeostasis and reduces 1,25- dihydroxyvitamin D synthesis. Recent data have highlighted the relevant direct FGF-23 effects on the myocardium, and high plasma levels of FGF-23 have been associated with adverse cardiovascular outcomes in humans, such as heart failure and arrhythmias. Therefore, FGF-23 has emerged as a novel biomarker of cardiovascular risk. experimental data suggest FGF-23 as a direct mediator of cardiac hypertrophy development, cardiac fibrosis and cardiac dysfunction via specific myocardial FGF receptor (FGFR) activation.
Find documents for the lot
Example Instructions for Use (RUO)
Example Instructions for Use (RUO)
