| Cat. No. | Size |
Price |
|
|---|---|---|---|
| New 326076529 | 96 wells (1 kit) |
Sandwich ELISA
Serum
1 µl/well
On blue ice packs. Upon receipt, store the product at the temperature recommended below.
Store the complete kit at 2–8°C. Under these conditions, the kit is stable until the expiration date (see label on the box).
200 - 6,3 pg/ml
2 pg/ml
less than CV =7%
less than CV =10%
Autoimmunity
SCCA(squamous cell carcinoma antigen) is a serine protease inhibitor belonging to serpin superfamily, which is a protein with a molecular weight of about 45 kDa produced mainly by epithelial cells. SCCA contains the isoforms SCCA1(SERPIN B3) and SCCA2(SERPIN B4), which are independent gene products transcribed from distinct loci, albeit with very high-amino-acid homologies of 91%.It is known that interleukin 13 (IL-13), one of the type Th2 cytokines, plays crucial roles in allergic inflammation. SCCA2 was identified as one of the molecules whose expression is elevated when airway epithelial cells are stimulated with IL-4 and IL-13, cytokines that are central in allergic responses). Serum SCCA2 levels in children with atopic dermatitis have been reported to be significantly elevated according to the severity of the disease, even when compared with existing blood tests. In the treatment of atopic dermatitis, it is important to select and use antiinflammatory drugs appropriately according to their severity. It was suggested that serum SCCA2 could be a useful marker as an indicator of the severity of childhood atopic dermatitis.