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Human Tau (pT231) ELISA

  • Regulatory status:RUO
  • Type:Sandwich ELISA, HRP-labelled antibody
  • Other names:Neurofibrillary tangle protein, Paired helical filament-tau, PHF-tau
  • Species:Human
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Cat. No. Size Price


New RIG016R 96 wells (1 kit)
PubMed Product Details
Technical Data

Type

Sandwich ELISA, HRP-labelled antibody

Applications

Cerebrospinal fluid, Cell lysate

Sample Requirements

50 µL/well

Storage/Expiration

Store the complete kit at 2–8°C. Under these conditions, the kit is stable until the expiration date (see label on the box). Do not freeze.

Calibration Range

1.56-100 U/µL

Limit of Detection

0.7 units/mL

Summary

Features

  • The total assay time is 4 hours

Summary

Tau is a microtubule-associated protein found predominantly in neuronal axons of the vertebrate brain. Human tau exists as six different isoforms that result from alternative splicing of the single transcript derived from a gene located on chromosome 17. The molecular weight of the tau isoforms ranges from 48 kDa to 68 kDa. Tau protein is highly soluble and normally attached to axonal microtubules. Tau stabilizes the microtubules and makes them rigid. Tau interacts with actin in the cytoskeleton and neuronal outgrowth, anchors enzymes such as protein kinases and phosphatases, and regulates intracellular vesicle transport. Tau is phosphorylated by numerous serine/threonine kinases, including GSK-3β, PKA, PKC, CDK5, MARK, JNK, p38MAPK and casein kinase II. Tau phosphorylation regulates both normal and pathological functions of this protein.

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