The receptor of the cytokine IL-2 plays a crucial role in the regulation of the immune response. Binding of IL-2 to its receptor (IL-2R) on the surface of T-lymphocytes triggers a series of intracellular signaling events that result in the activation and proliferation of resting T cells and in the generation of helper, suppressor and cytotoxic T cells, which mediate immune reactions. sIL-2R is a marker for T cell activation. It can be an indicator of a wide spectrum of disorders involving immune activation. IL2R can be found at significantly elevated levels in a broad range of disorders such as tumor diseases, autoimmune diseases (e.g. sarcoidosis), organ rejection and various infections.