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Manufactured by BioVendor

Leptin Human ELISA, Clinical Range

  • Regulatory status:RUO
  • Type:Sandwich ELISA, HRP-labelled antibody
  • Other names:Obesity factor, Obese protein, LEP, OB, OBS
  • Species:Human
Please select your region to see available products and prices.
Cat. No. Size Price


RD191001100 96 wells (1 kit)
PubMed Product Details
Technical Data

Type

Sandwich ELISA, HRP-labelled antibody

Applications

Serum, Plasma-EDTA, Plasma-Heparin, Plasma-Citrate

Sample Requirements

35 µl/well

Shipping

At ambient temperature. Upon receipt, store the product at the temperature recommended below.

Storage/Expiration

Store the kit at 2–8°C. Under these conditions, the kit is stable until the expiration date (see label on the box).

Calibration Curve

Calibration Range

1-50 ng/ml

Limit of Detection

0.2 ng/ml

Intra-assay (Within-Run)

n=8, CV = 5.9%

Inter-assay (Run-to-Run)

n=6, CV = 5.6%

Spiking Recovery

92.1%

Dilution Linearity

100.8%

Crossreactivity

  • bovine Non-detectable
  • cat Non-detectable
  • dog Non-detectable
  • goat Non-detectable
  • hamster Non-detectable
  • horse Non-detectable
  • monkey Non-detectable
  • mouse Non-detectable
  • pig Non-detectable
  • rabbit Non-detectable
  • rat Non-detectable
  • sheep Non-detectable
  • chicken Not tested
  • human Yes

Note

More about Leptin on BioVendor Scientific Blog

Summary

Features

  • European Union: for in vitro diagnostic use
  • Rest of the world: for research use only!
  • The total assay time is less than 2.5 hours
  • The kit measures total leptin
  • Assay format is 96 wells
  • Quality Controls are human serum based
  • Standards are recombinant protein based
  • Components of the kit are provided ready to use, concentrated or lyophilized

Research topic

Diabetology - Other Relevant Products, Energy metabolism and body weight regulation, Reproduction

Summary

Leptin, the product of the ob (obese) gene, is a single-chain 16 kDa protein consisting of 146
amino acid residues. Leptin is produced mainly in the adipose tissue, and is considered to play
an important role in appetite control, fat metabolism and body weight regulation. It targets the
central nervous system, particularly hypothalamus, affecting food intake. The primary effect of
leptin appears to be mediated by leptin receptors expressed mainly in the hypothalamus. In
humans, leptin levels correlate with body mass index (BMI) and percentage body fat, and are
elevated even in obese individuals. Leptin has a dual action; it decreases the appetite and
increases energy consumption, causing more fat to be burned. Leptin is secreted in circadian
fashion with nocturnal rise in both lean and obese patients.

Mutations of the ob gene resulting in leptin deficiency are the cause of obesity in the ob/ob
mice. Endogeneous leptin can normalize their body weight. In contrast, high levels of leptin in
obese human subjects point to an insensitivity to endogeneous leptin.
Other factors in addition to the amount of body fat appear to regulate leptin action: insulin,
glucocorticoids, catecholamines and sex hormones. Studies have shown that leptin may be
linked to reproductive function.

Product References (115)

References

  • Lambova SN, Batsalova T, Moten D, Stoyanova S, Georgieva E, Belenska-Todorova L, Kolchakova D, Dzhambazov B. Serum Leptin and Resistin Levels in Knee Osteoarthritis-Clinical and Radiologic Links: Towards Precise Definition of Metabolic Type Knee Osteoarthritis. Biomedicines. 2021 Aug 15;9(8):1019. doi: 10.3390/biomedicines9081019. PubMed PMID: 34440223. PubMed CentralPMCID: PMC8393571. See more on PubMed
  • Miklankova D, Markova I, Hüttl M, Zapletalova I, Poruba M, Malinska H. Metformin Affects Cardiac Arachidonic Acid Metabolism and Cardiac Lipid Metabolite Storage in a Prediabetic Rat Model. Int J Mol Sci. 2021 Jul 19;22(14):7680. doi: 10.3390/ijms22147680. PubMed PMID: 34299301. PubMed CentralPMCID: PMC8305829. See more on PubMed
  • Tam FI, Seidel M, Boehm I, Ritschel F, Bahnsen K, Biemann R, Weidner K, Roessner V, Ehrlich S. Peptide YY(3-36) concentration in acute- and long-term recovered anorexia nervosa. Eur J Nutr. 2020 Dec;59(8):3791-3799. doi: 10.1007/s00394-020-02210-7. Epub 2020 Mar 12. PubMed PMID: 32166384. PubMed CentralPMCID: PMC7669786. See more on PubMed
  • Paduszyńska A, Sakowicz A, Banach M, Maciejewski M, Dąbrowa M, Bielecka-Dąbrowa A. Cardioprotective properties of leptin in patients with excessive body mass. Ir J Med Sci. 2020 Nov;189(4):1259-1265. doi: 10.1007/s11845-020-02211-9. Epub 2020 Mar 20. PubMed PMID: 32198598. PubMed CentralPMCID: PMC7554003. See more on PubMed
  • Tsai TA, Tsai CK, Huang LT, Sheen JM, Tiao MM, Tain YL, Chen CC, Lin IC, Lai YJ, Tsai CC, Lin YJ, Yu HR. Maternal Resveratrol Treatment Re-Programs and Maternal High-Fat Diet-Induced Retroperitoneal Adiposity in Male Offspring. Int J Environ Res Public Health. 2020 Apr 17;17(8):2780. doi: 10.3390/ijerph17082780. PubMed PMID: 32316577. PubMed CentralPMCID: PMC7215689. See more on PubMed
  • Gilbert T, Roche S, Blond E, Bar JY, Drai J, Cuerq C, Haution-Bitker M, Ecochard R, Bonnefoy M. Association between Peripheral Leptin and Adiponectin Levels and Cognitive Decline in Patients with Neurocognitive Disorders ≥65 Years. J Alzheimers Dis. 2018;66(3):1255-1264. doi: 10.3233/JAD-180533. PubMed PMID: 30400097. PubMed CentralPMCID: PMC6294588. See more on PubMed
  • Ojanen T, Jalanko P, Kyröläinen H. Physical fitness, hormonal, and immunological responses during prolonged military field training. Physiol Rep. 2018 Sep;6(17):e13850. doi: 10.14814/phy2.13850. PubMed PMID: 30187684. PubMed CentralPMCID: PMC6125608. See more on PubMed
  • Adamska-Patruno E, Ostrowska L, Goscik J, Pietraszewska B, Kretowski A, Gorska M. The relationship between the leptin/ghrelin ratio and meals with various macronutrient contents in men with different nutritional status: a randomized crossover study. Nutr J. 2018 Dec 28;17(1):118. doi: 10.1186/s12937-018-0427-x. PubMed PMID: 30593267. PubMed CentralPMCID: PMC6309055. See more on PubMed
  • Saeidi A, Jabbour G, Ahmadian M, Abbassi-Daloii A, Malekian F, Hackney AC, Saedmocheshi S, Basati G, Ben Abderrahman A, Zouhal H. Independent and Combined Effects of Antioxidant Supplementation and Circuit Resistance Training on Selected Adipokines in Postmenopausal Women. Front Physiol. 2019 Apr 26;10:484. doi: 10.3389/fphys.2019.00484. eCollection 2019. PubMed PMID: 31105587. PubMed CentralPMCID: PMC6499001. See more on PubMed
  • Adamska-Patruno E, Ostrowska L, Goscik J, Fiedorczuk J, Moroz M, Kretowski A, Gorska M. The Differences in Postprandial Serum Concentrations of Peptides That Regulate Satiety/Hunger and Metabolism after Various Meal Intake, in Men with Normal vs. Excessive BMI. Nutrients. 2019 Feb 26;11(3):493. doi: 10.3390/nu11030493. PubMed PMID: 30813625. PubMed CentralPMCID: PMC6471764. See more on PubMed
  • Elie AGIM, Bloksgaard M, Sun WY, Yang K, Man AWC, Xu A, Irmukhamedov A, Riber LP, Wang Y, De Mey JGR. Local enrichment of fatty acid-binding protein 4 in the pericardial cavity of cardiovascular disease patients. PLoS One. 2018 Nov 5;13(11):e0206802. doi: 10.1371/journal.pone.0206802. eCollection 2018. PubMed PMID: 30395653. PubMed CentralPMCID: PMC6218069. See more on PubMed
  • Kratochvilova H, Lacinova Z, Klouckova J, Kavalkova P, Cinkajzlova A, Trachta P, Krizova J, Benes M, Dolezalova K, Fried M, Vlasakova Z, Pelikanova T, Spicak J, Mraz M, Haluzik M. Neudesin in obesity and type 2 diabetes mellitus: the effect of acute fasting and weight reducing interventions. Diabetes Metab Syndr Obes. 2019 Mar 28;12:423-430. doi: 10.2147/DMSO.S193259. eCollection 2019. PubMed PMID: 30992678. PubMed CentralPMCID: PMC6445223. See more on PubMed
  • Cinkajzlová A, Mráz M, Lacinová Z, Kloučková J, Kaválková P, Kratochvílová H, Trachta P, Křížová J, Haluzíková D, Škrha J, Papežová H, Haluzík M. Angiopoietin-like protein 3 and 4 in obesity, type 2 diabetes mellitus, and malnutrition: the effect of weight reduction and realimentation. Nutr Diabetes. 2018 Apr 25;8(1):21. doi: 10.1038/s41387-018-0032-2. PubMed PMID: 29695708. PubMed CentralPMCID: PMC5916880. See more on PubMed
  • Szczepankiewicz D, Sobkowiak P, Narożna B, Wojsyk-Banaszak I, Bręborowicz A, Szczepankiewicz A. Leptin gene polymorphism affects leptin level in childhood asthma. World J Pediatr. 2018 Dec;14(6):601-606. doi: 10.1007/s12519-018-0182-2. Epub 2018 Sep 10. PubMed PMID: 30203371. PubMed CentralPMCID: PMC6208747. See more on PubMed
  • Dumon C, Diabira D, Chudotvorova I, Bader F, Sahin S, Zhang J, Porcher C, Wayman G, Medina I, Gaiarsa JL. The adipocyte hormone leptin sets the emergence of hippocampal inhibition in mice. Elife. 2018 Aug 14;7:e36726. doi: 10.7554/eLife.36726. PubMed PMID: 30106375. PubMed CentralPMCID: PMC6112852. See more on PubMed
  • Seidel M, King JA, Ritschel F, Boehm I, Geisler D, Bernardoni F, Beck M, Pauligk S, Biemann R, Strobel A, Goschke T, Walter H, Roessner V, Ehrlich S. Processing and regulation of negative emotions in anorexia nervosa: An fMRI study. Neuroimage Clin. 2017 Dec 24;18:1-8. doi: 10.1016/j.nicl.2017.12.035. eCollection 2018. PubMed PMID: 29321971. PubMed CentralPMCID: PMC5756056. See more on PubMed
  • Wiecek M, Szymura J, Maciejczyk M, Kantorowicz M, Szygula Z. Acute Anaerobic Exercise Affects the Secretion of Asprosin, Irisin, and Other Cytokines - A Comparison Between Sexes. Front Physiol. 2018 Dec 10;9:1782. doi: 10.3389/fphys.2018.01782. eCollection 2018. PubMed PMID: 30618797. PubMed CentralPMCID: PMC6295572. See more on PubMed
  • Fryczkowski M, Bułdak RJ, Hejmo T, Kukla M, Żwirska-Korczala K. Circulating Levels of Omentin, Leptin, VEGF, and HGF and Their Clinical Relevance with PSA Marker in Prostate Cancer. Dis Markers. 2018 Aug 16;2018:3852401. doi: 10.1155/2018/3852401. eCollection 2018. PubMed PMID: 30186533. PubMed CentralPMCID: PMC6116468. See more on PubMed
  • Wilson R, Willis J, Gearry RB, Hughes A, Lawley B, Skidmore P, Frampton C, Fleming E, Anderson A, Jones L, Tannock GW, Carr AC. SunGold Kiwifruit Supplementation of Individuals with Prediabetes Alters Gut Microbiota and Improves Vitamin C Status, Anthropometric and Clinical Markers. Nutrients. 2018 Jul 12;10(7):895. doi: 10.3390/nu10070895. PubMed PMID: 30002355. PubMed CentralPMCID: PMC6073280. See more on PubMed
  • Rozmilowska I, Czyzewski D, Mazur B, Adamczyk-Sowa M. What is the role of adipokines in myasthenia gravis?. Ther Clin Risk Manag. 2018 Aug 28;14:1515-1525. doi: 10.2147/TCRM.S163966. eCollection 2018. PubMed PMID: 30214215. PubMed CentralPMCID: PMC6118871. See more on PubMed
  • Szewczyk-Golec K, Rajewski P, Gackowski M, Mila-Kierzenkowska C, Wesołowski R, Sutkowy P, Pawłowska M, Woźniak A. Melatonin Supplementation Lowers Oxidative Stress and Regulates Adipokines in Obese Patients on a Calorie-Restricted Diet. Oxid Med Cell Longev. 2017;2017:8494107. doi: 10.1155/2017/8494107. Epub 2017 Sep 21. PubMed PMID: 29142618. PubMed CentralPMCID: PMC5632922. See more on PubMed
  • Rubino E, Vacca A, Govone F, Gai A, Boschi S, Zucca M, De Martino P, Gentile S, Pinessi L, Rainero I. Investigating the role of adipokines in chronic migraine. Cephalalgia. 2017 Oct;37(11):1067-1073. doi: 10.1177/0333102416665871. Epub 2016 Aug 22. PubMed PMID: 27553954. See more on PubMed
  • Wilson R, Willis J, Gearry R, Skidmore P, Fleming E, Frampton C, Carr A. Inadequate Vitamin C Status in Prediabetes and Type 2 Diabetes Mellitus: Associations with Glycaemic Control, Obesity, and Smoking. Nutrients. 2017 Sep 9;9(9):997. doi: 10.3390/nu9090997. PubMed PMID: 28891932. PubMed CentralPMCID: PMC5622757. See more on PubMed
  • Bahijri SM, Ajabnoor G, Hegazy GA, Alsheikh L, Moumena MZ, Bashanfar BM, Alzahrani AH. Supplementation with Oligonol, Prevents Weight Gain and Improves Lipid Profile in Overweight and Obese Saudi Females. Curr Nutr Food Sci. 2018 Apr;14(2):164-170. doi: 10.2174/1573401313666170609101408. PubMed PMID: 29853817. PubMed CentralPMCID: PMC5907059. See more on PubMed
  • Puurunen VP, Lepojärvi ES, Piira OP, Hedberg P, Junttila MJ, Ukkola O, Huikuri HV. High plasma leptin levels are associated with impaired diastolic function in patients with coronary artery disease. Peptides. 2016 Oct;84:17-21. doi: 10.1016/j.peptides.2016.08.002. Epub 2016 Aug 11. PubMed PMID: 27524739. See more on PubMed
  • Namavar Jahromi B, Dabaghmanesh MH, Parsanezhad ME, Fatehpoor F. Association of leptin and insulin resistance in PCOS: A case-controlled study. Int J Reprod Biomed. 2017 Jul;15(7):423-428. PubMed PMID: 29177243. PubMed CentralPMCID: PMC5601933. See more on PubMed
  • Mitanchez D, Jacqueminet S, Nizard J, Tanguy ML, Ciangura C, Lacorte JM, De Carne C, Foix L'Hélias L, Chavatte-Palmer P, Charles MA, Dommergues M. Effect of maternal obesity on birthweight and neonatal fat mass: A prospective clinical trial. PLoS One. 2017 Jul 27;12(7):e0181307. doi: 10.1371/journal.pone.0181307. eCollection 2017. PubMed PMID: 28750045. PubMed CentralPMCID: PMC5531500. See more on PubMed
  • Behrouz V, Jazayeri S, Aryaeian N, Zahedi MJ, Hosseini F. Effects of Probiotic and Prebiotic Supplementation on Leptin, Adiponectin, and Glycemic Parameters in Non-alcoholic Fatty Liver Disease: A Randomized Clinical Trial. Middle East J Dig Dis. 2017 Jul;9(3):150-157. doi: 10.15171/mejdd.2017.66. PubMed PMID: 28894517. PubMed CentralPMCID: PMC5585907. See more on PubMed
  • Chen LW, Chen FP, Hsieh CW, Kuo SF, Chien RN. Analysis of the associations among Helicobacter pylori infection, adiponectin, leptin, and 10-year fracture risk using the fracture risk assessment tool: A cross-sectional community-based study. PLoS One. 2017 Apr 7;12(4):e0175365. doi: 10.1371/journal.pone.0175365. eCollection 2017. PubMed PMID: 28388631. PubMed CentralPMCID: PMC5384782. See more on PubMed
  • Jean-Luc Gradidge P, Norris SA, Jaff NG, Crowther NJ. Metabolic and Body Composition Risk Factors Associated with Metabolic Syndrome in a Cohort of Women with a High Prevalence of Cardiometabolic Disease. PLoS One. 2016 Sep 2;11(9):e0162247. doi: 10.1371/journal.pone.0162247. eCollection 2016. PubMed PMID: 27589387. PubMed CentralPMCID: PMC5010252. See more on PubMed
  • Lee HJ, Jung H, Cho H, Lee K, Kwak HK, Hwang KT. Dietary Black Raspberry Seed Oil Ameliorates Inflammatory Activities in db/db Mice. Lipids. 2016 Jun;51(6):715-27. doi: 10.1007/s11745-016-4159-4. Epub 2016 May 10. PubMed PMID: 27165261. See more on PubMed
  • Woo YC, Lee CH, Fong CH, Xu A, Tso AW, Cheung BM, Lam KS. Serum fibroblast growth factor 21 is a superior biomarker to other adipokines in predicting incident diabetes. Clin Endocrinol (Oxf). 2017 Jan;86(1):37-43. doi: 10.1111/cen.13229. Epub 2016 Sep 29. PubMed PMID: 27611701. See more on PubMed
  • Cinkajzlova A, Lacinova Z, Klouckova J, Kavalkova P, Trachta P, Kosak M, Haluzikova D, Papezova H, Mraz M, Haluzík M. Angiopoietin-like protein 6 in patients with obesity, type 2 diabetes mellitus, and anorexia nervosa: The influence of very low-calorie diet, bariatric surgery, and partial realimentation. Endocr Res. 2017 Feb;42(1):22-30. doi: 10.3109/07435800.2016.1169544. Epub 2016 May 2. PubMed PMID: 27135654. See more on PubMed
  • Baeza I, Vigo L, de la Serna E, Calvo-Escalona R, Merchán-Naranjo J, Rodríguez-Latorre P, Arango C, Castro-Fornieles J. The effects of antipsychotics on weight gain, weight-related hormones and homocysteine in children and adolescents: a 1-year follow-up study. Eur Child Adolesc Psychiatry. 2017 Jan;26(1):35-46. doi: 10.1007/s00787-016-0866-x. Epub 2016 May 21. PubMed PMID: 27209421. See more on PubMed
  • Pourghassem Gargari B, Houjeghani S, Farzadi L, Houjeghani S, Safaeiyan A. Relationship between Serum Leptin, Ghrelin and Dietary Macronutrients in Women with Polycystic Ovary Syndrome. Int J Fertil Steril. 2015 Oct-Dec;9(3):313-21. doi: 10.22074/ijfs.2015.4546. Epub 2015 Oct 31. PubMed PMID: 26644854. PubMed CentralPMCID: PMC4671384. See more on PubMed
  • Wójcik K, Jabłonowska E, Omulecka A, Piekarska A. Insulin resistance, adipokine profile and hepatic expression of SOCS-3 gene in chronic hepatitis C. World J Gastroenterol. 2014 Aug 14;20(30):10449-56. doi: 10.3748/wjg.v20.i30.10449. PubMed PMID: 25132761. PubMed CentralPMCID: PMC4130852. See more on PubMed
  • Bužga M, Evžen M, Pavel K, Tomáš K, Vladislava Z, Pavel Z, Svagera Z. Effects of the intragastric balloon MedSil on weight loss, fat tissue, lipid metabolism, and hormones involved in energy balance. Obes Surg. 2014 Jun;24(6):909-15. doi: 10.1007/s11695-014-1191-4. PubMed PMID: 24488758. PubMed CentralPMCID: PMC4022986. See more on PubMed
  • Trachta P, Dostálová I, Haluzíková D, Kasalický M, Kaválková P, Drápalová J, Urbanová M, Lacinová Z, Mráz M, Haluzík M. Laparoscopic sleeve gastrectomy ameliorates mRNA expression of inflammation-related genes in subcutaneous adipose tissue but not in peripheral monocytes of obese patients. Mol Cell Endocrinol. 2014 Mar 5;383(1-2):96-102. doi: 10.1016/j.mce.2013.11.013. Epub 2013 Nov 27. PubMed PMID: 24291610. See more on PubMed
  • Dayer D, Nikbakht R, Kadkhodai Elyaderani M. Comparison of leptin concentrations between infertile women with polycystic ovary syndrome and fertile women. Iran J Reprod Med. 2013 Dec;11(12):1033-4. PubMed PMID: 24639732. PubMed CentralPMCID: PMC3941400. See more on PubMed
  • Luque-Ramírez M, Martínez-García MÁ, Montes-Nieto R, Fernández-Durán E, Insenser M, Alpañés M, Escobar-Morreale HF. Sexual dimorphism in adipose tissue function as evidenced by circulating adipokine concentrations in the fasting state and after an oral glucose challenge. Hum Reprod. 2013 Jul;28(7):1908-18. doi: 10.1093/humrep/det097. Epub 2013 Apr 4. PubMed PMID: 23559188. See more on PubMed
  • Disse E, Graeppi-Dulac J, Joncour-Mills G, Dupuis O, Thivolet C. Heterogeneity of pregnancy outcomes and risk of LGA neonates in Caucasian females according to IADPSG criteria for gestational diabetes mellitus. Diabetes Metab. 2013 Apr;39(2):132-8. doi: 10.1016/j.diabet.2012.09.006. Epub 2012 Nov 22. PubMed PMID: 23182459. See more on PubMed
  • Tsaroucha A, Daniil Z, Malli F, Georgoulias P, Minas M, Kostikas K, Bargiota A, Zintzaras E, Gourgoulianis KI. Leptin, adiponectin, and ghrelin levels in female patients with asthma during stable and exacerbation periods. J Asthma. 2013 Mar;50(2):188-97. doi: 10.3109/02770903.2012.747101. Epub 2012 Dec 21. PubMed PMID: 23259727. See more on PubMed
  • Hulejová H, Levitová A, Kuklová M, Stochl J, Haluzík M, Pavelka K, Vencovský J, Senolt L. No effect of physiotherapy on the serum levels of adipocytokines in patients with ankylosing spondylitis. Clin Rheumatol. 2012 Jan;31(1):67-71. doi: 10.1007/s10067-011-1773-7. Epub 2011 May 28. PubMed PMID: 21618078. See more on PubMed
  • Šenolt L, Kuklová M, Cerezo LA, Hulejová H, Filková M, Bošanská L, Pecha O, Pavelka K, Haluzík M, Vencovský J. Adipokine profile is modulated in subcutaneous adipose tissue by TNFα inhibitors in patients with rheumatoid arthritis. Ann Rheum Dis. 2011 Nov;70(11):2054-6. doi: 10.1136/ard.2011.152603. Epub 2011 May 27. PubMed PMID: 21622768. See more on PubMed
  • Ďurovcová V, Marek J, Hána V, Matoulek M, Zikán V, Haluzíková D, Kaválková P, Lacinová Z, Kršek M, Haluzík M. Plasma concentrations of adipocyte fatty acid binding protein in patients with Cushing's syndrome. Physiol Res. 2010;59(6):963-971. doi: 10.33549/physiolres.931842. Epub 2010 Jun 9. PubMed PMID: 20533865. See more on PubMed
  • Bronsky J, Mitrova K, Karpisek M, Mazoch J, Durilova M, Fisarkova B, Stechova K, Prusa R, Nevoral J. Adiponectin, AFABP, and leptin in human breast milk during 12 months of lactation. J Pediatr Gastroenterol Nutr. 2011 Apr;52(4):474-7. doi: 10.1097/MPG.0b013e3182062fcc. PubMed PMID: 21407103. See more on PubMed
  • Arnold T, Brandlhofer S, Vrtikapa K, Stangl H, Hermann M, Zwiauer K, Mangge H, Karwautz A, Huemer J, Koller D, Schneider WJ, Strobl W. Effect of obesity on plasma clusterin, [corrected] a proposed modulator of leptin action. Pediatr Res. 2011 Mar;69(3):237-42. doi: 10.1203/PDR.0b013e31820930cb. PubMed PMID: 21135756. See more on PubMed
  • Mangge H, Freytag F, Almer G, Weghuber D, Bauer-Denk C, Fuchs D. Serum neopterin is not increased in obese juveniles. J Obes. 2011;2011:946795. doi: 10.1155/2011/946795. Epub 2011 Jan 12. PubMed PMID: 21274279. PubMed CentralPMCID: PMC3025381. See more on PubMed
  • Koch A, Weiskirchen R, Zimmermann HW, Sanson E, Trautwein C, Tacke F. Relevance of serum leptin and leptin-receptor concentrations in critically ill patients. Mediators Inflamm. 2010;2010:473540. doi: 10.1155/2010/473540. Epub 2010 Sep 7. PubMed PMID: 20871818. PubMed CentralPMCID: PMC2943118. See more on PubMed
  • Azzoni L, Crowther NJ, Firnhaber C, Foulkes AS, Yin X, Glencross D, Gross R, Kaplan MD, Papasavvas E, Schulze D, Stevens W, van der Merwe T, Waisberg R, Sanne I, Montaner LJ. Association between HIV replication and serum leptin levels: an observational study of a cohort of HIV-1-infected South African women. J Int AIDS Soc. 2010 Sep 7;13:33. doi: 10.1186/1758-2652-13-33. PubMed PMID: 20822522. PubMed CentralPMCID: PMC2941743. See more on PubMed
  • Kukla M, Zwirska-Korczala K, Gabriel A, Waluga M, Warakomska I, Szczygiel B, Berdowska A, Mazur W, Wozniak-Grygiel E, Kryczka W. Chemerin, vaspin and insulin resistance in chronic hepatitis C. J Viral Hepat. 2010 Sep;17(9):661-7. doi: 10.1111/j.1365-2893.2009.01224.x. Epub 2009 Nov 11. PubMed PMID: 20002564. See more on PubMed
  • Mente A, Razak F, Blankenberg S, Vuksan V, Davis AD, Miller R, Teo K, Gerstein H, Sharma AM, Yusuf S, Anand SS. Ethnic variation in adiponectin and leptin levels and their association with adiposity and insulin resistance. Diabetes Care. 2010 Jul;33(7):1629-34. doi: 10.2337/dc09-1392. Epub 2010 Apr 22. PubMed PMID: 20413520. PubMed CentralPMCID: PMC2890372. See more on PubMed
  • Florentin M, Liberopoulos EN, Tellis CC, Derdemezis CS, Elisaf M, Tselepis A. Effects of rimonabant, as monotherapy and in combination with fenofibrate or ezetimibe, on plasma adipokine levels: a pilot study. Angiology. 2010 May;61(4):365-71. doi: 10.1177/0003319709352488. Epub 2009 Nov 18. PubMed PMID: 19926622. See more on PubMed
  • Semnani S, Roshandel G, Keshtkar A, Najafi L, Amiriani T, Farajollahi M, Moradi A, Joshaghani H. Serum leptin levels and irritable bowel syndrome: a new hypothesis. J Clin Gastroenterol. 2009 Oct;43(9):826-30. doi: 10.1097/MCG.0b013e3181986900. PubMed PMID: 19398923. See more on PubMed
  • Dostálová I, Kaválková P, Papežová H, Domluvilová D, Zikán V, Haluzík M. Association of macrophage inhibitory cytokine-1 with nutritional status, body composition and bone mineral density in patients with anorexia nervosa: the influence of partial realimentation. Nutr Metab (Lond). 2010 Apr 23;7:34. doi: 10.1186/1743-7075-7-34. PubMed PMID: 20416056. PubMed CentralPMCID: PMC2875215. See more on PubMed
  • Saeed Z, Haleh S, Afsaneh M, Soheila A, Amir Hassan Z, Farah I, Banafsheh T, Elham SS, Narges MB, Mahmood JT. Serum leptin levels in women with immunological recurrent abortion. J Reprod Infertil. 2010 Apr;11(1):47-52. PubMed PMID: 23926480. PubMed CentralPMCID: PMC3719276. See more on PubMed
  • Hancke K, Grubeck D, Hauser N, Kreienberg R, Weiss JM. Adipocyte fatty acid-binding protein as a novel prognostic factor in obese breast cancer patients. Breast Cancer Res Treat. 2010 Jan;119(2):367-7. doi: 10.1007/s10549-009-0577-9. PubMed PMID: 19842034. See more on PubMed
  • Lin SY, Huang SC, Sheu WH. Circulating adiponectin concentrations were related to free thyroxine levels in thyroid cancer patients after thyroid hormone withdrawal. Metabolism. 2010 Feb;59(2):195-9. doi: 10.1016/j.metabol.2009.06.032. Epub 2009 Sep 17. PubMed PMID: 19765779. See more on PubMed
  • Sáinz N, Rodríguez A, Catalán V, Becerril S, Ramírez B, Gómez-Ambrosi J, Frühbeck G. Leptin administration favors muscle mass accretion by decreasing FoxO3a and increasing PGC-1alpha in ob/ob mice. PLoS One. 2009 Sep 4;4(9):e6808. doi: 10.1371/journal.pone.0006808. PubMed PMID: 19730740. PubMed CentralPMCID: PMC2733298. See more on PubMed
  • Haluzíková D, Dostálová I, Kaválková P, Roubíček T, Mráz M, Papežová H, Haluzík M. Serum concentrations of adipocyte fatty acid binding protein in patients with anorexia nervosa. Physiol Res. 2009;58(4):577-581. doi: 10.33549/physiolres.931575. Epub 2008 Jul 25. PubMed PMID: 18657008. See more on PubMed
  • Mitchell SE, Nogueiras R, Morris A, Tovar S, Grant C, Cruickshank M, Rayner DV, Dieguez C, Williams LM. Leptin receptor gene expression and number in the brain are regulated by leptin level and nutritional status. J Physiol. 2009 Jul 15;587(Pt 14):3573-85. doi: 10.1113/jphysiol.2009.173328. Epub 2009 Jun 2. PubMed PMID: 19491239. PubMed CentralPMCID: PMC2742282. See more on PubMed
  • Olszanecka-Glinianowicz M, Zahorska-Markiewicz B, Kocełak P, Janowska J, Semik-Grabarczyk E, Wikarek T, Gruszka W, Dabrowski P. Is chronic inflammation a possible cause of obesity-related depression?. Mediators Inflamm. 2009;2009:439107. doi: 10.1155/2009/439107. Epub 2009 Jun 29. PubMed PMID: 19587822. PubMed CentralPMCID: PMC2705765. See more on PubMed
  • Capel F, Klimcáková E, Viguerie N, Roussel B, Vítková M, Kováciková M, Polák J, Kovácová Z, Galitzky J, Maoret JJ, Hanácek J, Pers TH, Bouloumié A, Stich V, Langin D. Macrophages and adipocytes in human obesity: adipose tissue gene expression and insulin sensitivity during calorie restriction and weight stabilization. Diabetes. 2009 Jul;58(7):1558-67. doi: 10.2337/db09-0033. Epub 2009 Apr 28. PubMed PMID: 19401422. PubMed CentralPMCID: PMC2699855. See more on PubMed
  • Aeberli I, Beljean N, Lehmann R, I'Allemand D, Spinas GA, Zimmermann MB. The increase of fatty acid-binding protein aP2 in overweight and obese children: interactions with dietary fat and impact on measures of subclinical inflammation. Int J Obes (Lond). 2008 Oct;32(10):1513-20. doi: 10.1038/ijo.2008.128. Epub 2008 Aug 5. PubMed PMID: 18679408. See more on PubMed
  • Ding Q, Mracek T, Gonzalez-Muniesa P, Kos K, Wilding J, Trayhurn P, Bing C. Identification of macrophage inhibitory cytokine-1 in adipose tissue and its secretion as an adipokine by human adipocytes. Endocrinology. 2009 Apr;150(4):1688-96. doi: 10.1210/en.2008-0952. Epub 2008 Dec 12. PubMed PMID: 19074584. See more on PubMed
  • Karapanagiotou EM, Tsochatzis EA, Dilana KD, Tourkantonis I, Gratsias I, Syrigos KN. The significance of leptin, adiponectin, and resistin serum levels in non-small cell lung cancer (NSCLC). Lung Cancer. 2008 Sep;61(3):391-7. doi: 10.1016/j.lungcan.2008.01.018. Epub 2008 Mar 14. PubMed PMID: 18342391. See more on PubMed
  • Stejskal D, Adamovská S, Bartek J, Juráková R, Prosková J. Resistin - concentrations in persons with type 2 diabetes mellitus and in individuals with acute inflammatory disease. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2003 Nov;147(1):63-9. PubMed PMID: 15034607. See more on PubMed
  • Petzel M, Stejskal D, Jedelsky L, Kadalova L, Safarcik K. The influence of estradiole and tibolone administration on leptin levels in women with surgically induced menopause. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2008 Jun;152(1):101-5. doi: 10.5507/bp.2008.016. PubMed PMID: 18795083. See more on PubMed
  • Dostálová I, Kaválková P, Haluzíková D, Lacinová Z, Mráz M, Papezová H, Haluzík M. Plasma concentrations of fibroblast growth factors 19 and 21 in patients with anorexia nervosa. J Clin Endocrinol Metab. 2008 Sep;93(9):3627-32. doi: 10.1210/jc.2008-0746. Epub 2008 Jun 17. PubMed PMID: 18559909. See more on PubMed
  • Dolinková M, Dostálová I, Lacinová Z, Michalský D, Haluzíková D, Mráz M, Kasalický M, Haluzík M. The endocrine profile of subcutaneous and visceral adipose tissue of obese patients. Mol Cell Endocrinol. 2008 Sep 10;291(1-2):63-70. doi: 10.1016/j.mce.2008.05.001. Epub 2008 May 9. PubMed PMID: 18565643. See more on PubMed
  • Cambuli VM, Musiu MC, Incani M, Paderi M, Serpe R, Marras V, Cossu E, Cavallo MG, Mariotti S, Loche S, Baroni MG. Assessment of adiponectin and leptin as biomarkers of positive metabolic outcomes after lifestyle intervention in overweight and obese children. J Clin Endocrinol Metab. 2008 Aug;93(8):3051-7. doi: 10.1210/jc.2008-0476. Epub 2008 May 20. PubMed PMID: 18492759. See more on PubMed
  • Díez ML, Santolaria F, Tejera A, Alemán MR, González-Reimers E, Milena A, de la Vega MJ, Martínez-Riera A. Serum leptin levels in community acquired pneumonia (CAP) are related to nutritional status and not to acute phase reaction. Cytokine. 2008 May;42(2):156-160. doi: 10.1016/j.cyto.2008.02.013. Epub 2008 Apr 18. PubMed PMID: 18396058. See more on PubMed
  • Lamota L, Bermudez-Silva FJ, Marco EM, Llorente R, Gallego A, Rodríguez de Fonseca F, Viveros MP. Effects of adolescent nicotine and SR 147778 (Surinabant) administration on food intake, somatic growth and metabolic parameters in rats. Neuropharmacology. 2008 Jan;54(1):194-205. doi: 10.1016/j.neuropharm.2007.07.004. Epub 2007 Jul 19. PubMed PMID: 17720206. See more on PubMed
  • Aydin HI, Yozgat Y, Demirkaya E, Olgun A, Okutan V, Lenk MK, Ozcan O. Correlation between vascular endothelial growth factor and leptin in children with cyanotic congenital heart disease. Turk J Pediatr. 2007 Oct-Dec;49(4):360-4. PubMed PMID: 18246735. See more on PubMed
  • Hoefle G, Saely CH, Risch L, Rein P, Koch L, Schmid F, Aczél S, Marte T, Langer P, Drexel H. Leptin, leptin soluble receptor and coronary atherosclerosis. Eur J Clin Invest. 2007 Aug;37(8):629-36. doi: 10.1111/j.1365-2362.2007.01842.x. PubMed PMID: 17635573. See more on PubMed
  • Moro C, Klimcakova E, Lolmède K, Berlan M, Lafontan M, Stich V, Bouloumié A, Galitzky J, Arner P, Langin D. Atrial natriuretic peptide inhibits the production of adipokines and cytokines linked to inflammation and insulin resistance in human subcutaneous adipose tissue. Diabetologia. 2007 May;50(5):1038-47. doi: 10.1007/s00125-007-0614-3. Epub 2007 Feb 23. PubMed PMID: 17318625. See more on PubMed
  • Giapros V, Evagelidou E, Challa A, Kiortsis D, Drougia A, Andronikou S. Serum adiponectin and leptin levels and insulin resistance in children born large for gestational age are affected by the degree of overweight. Clin Endocrinol (Oxf). 2007 Mar;66(3):353-9. doi: 10.1111/j.1365-2265.2006.02736.x. PubMed PMID: 17302868. See more on PubMed
  • Vitkova M, Klimcakova E, Kovacikova M, Valle C, Moro C, Polak J, Hanacek J, Capel F, Viguerie N, Richterova B, Bajzova M, Hejnova J, Stich V, Langin D. Plasma levels and adipose tissue messenger ribonucleic acid expression of retinol-binding protein 4 are reduced during calorie restriction in obese subjects but are not related to diet-induced changes in insulin sensitivity. J Clin Endocrinol Metab. 2007 Jun;92(6):2330-5. doi: 10.1210/jc.2006-2668. Epub 2007 Apr 3. PubMed PMID: 17405846. See more on PubMed
  • Schäffler A, Landfried K, Völk M, Fürst A, Büchler C, Schölmerich J, Herfarth H. Potential of adipocytokines in predicting peripancreatic necrosis and severity in acute pancreatitis: pilot study. J Gastroenterol Hepatol. 2007 Mar;22(3):326-34. doi: 10.1111/j.1440-1746.2006.04364.x. PubMed PMID: 17295762. See more on PubMed
  • Risch L, Saely C, Hoefle G, Rein P, Langer P, Gouya G, Marte T, Aczel S, Drexel H. Relationship between glomerular filtration rate and the adipokines adiponectin, resistin and leptin in coronary patients with predominantly normal or mildly impaired renal function. Clin Chim Acta. 2007 Feb;376(1-2):108-13. doi: 10.1016/j.cca.2006.07.026. Epub 2006 Jul 29. PubMed PMID: 16956602. See more on PubMed
  • Silha JV, Nyomba BL, Leslie WD, Murphy LJ. Ethnicity, insulin resistance, and inflammatory adipokines in women at high and low risk for vascular disease. Diabetes Care. 2007 Feb;30(2):286-91. doi: 10.2337/dc06-1073. PubMed PMID: 17259496. See more on PubMed
  • Maletínská L, Toma RS, Pirnik Z, Kiss A, Slaninová J, Haluzík M, Zelezná B. Effect of cholecystokinin on feeding is attenuated in monosodium glutamate obese mice. Regul Pept. 2006 Sep 11;136(1-3):58-63. doi: 10.1016/j.regpep.2006.04.020. Epub 2006 Jun 19. PubMed PMID: 16782213. See more on PubMed
  • Fernández-Rodríguez CM, López-Serrano P, Alonso S, Gutiérrez ML, Lledó JL, Pérez-Calle JL, Temiño R, Cacho G, Nevado M, Casas ML, Gasalla JM, Bonet B. Long-term reversal of hypocholesterolaemia in patients with chronic hepatitis C is related to sustained viral response and viral genotype. Aliment Pharmacol Ther. 2006 Aug 1;24(3):507-12. doi: 10.1111/j.1365-2036.2006.03000.x. PubMed PMID: 16886916. See more on PubMed
  • Pamuk GE, Demir M, Harmandar F, Yesil Y, Turgut B, Vural O. Leptin and resistin levels in serum of patients with hematologic malignancies: correlation with clinical characteristics. Exp Oncol. 2006 Sep;28(3):241-4. PubMed PMID: 17080020. See more on PubMed
  • Paul G, Schäffler A, Neumeier M, Fürst A, Bataillle F, Buechler C, Müller-Ladner U, Schölmerich J, Rogler G, Herfarth H. Profiling adipocytokine secretion from creeping fat in Crohn's disease. Inflamm Bowel Dis. 2006 Jun;12(6):471-7. doi: 10.1097/00054725-200606000-00005. PubMed PMID: 16775490. See more on PubMed
  • Hoareau L, Ravanan P, Gonthier MP, Delarue P, Gonçalves J, Césari M, Festy F, Roche R. Effect of PEA on LPS inflammatory action in human adipocytes. Cytokine. 2006 Jun;34(5-6):291-6. doi: 10.1016/j.cyto.2006.06.005. Epub 2006 Aug 1. PubMed PMID: 16884908. See more on PubMed
  • Bronsky J, Karpísek M, Bronská E, Pechová M, Jancíková B, Kotolová H, Stejskal D, Prusa R, Nevoral J. Adiponectin, adipocyte fatty acid binding protein, and epidermal fatty acid binding protein: proteins newly identified in human breast milk. Clin Chem. 2006 Sep;52(9):1763-70. doi: 10.1373/clinchem.2005.063032. Epub 2006 Jul 27. PubMed PMID: 16873294. See more on PubMed
  • Ripollés Piquer B, Nazih H, Bourreille A, Segain JP, Huvelin JM, Galmiche JP, Bard JM. Altered lipid, apolipoprotein, and lipoprotein profiles in inflammatory bowel disease: consequences on the cholesterol efflux capacity of serum using Fu5AH cell system. Metabolism. 2006 Jul;55(7):980-8. doi: 10.1016/j.metabol.2006.03.006. PubMed PMID: 16784973. See more on PubMed
  • Stejskal D, Růzicka V, Adamovská S, Juráková R, Prosková J, Jedelský L, Bartek J. Adiponectin concentrations as a criterion of metabolic control in persons with type 2 diabetes mellitus?. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2003 Dec;147(2):167-72. doi: 10.5507/bp.2003.023. PubMed PMID: 15037898. See more on PubMed
  • Jarkovská Z, Hodková M, Sazamová M, Rosická M, Dusilová-Sulková S, Marek J, Justová V, Lacinová Z, Haluzík M, Haas T, Krsek M. Plasma levels of active and total ghrelin in renal failure: a relationship with GH/IGF-I axis. Growth Horm IGF Res. 2005 Dec;15(6):369-76. doi: 10.1016/j.ghir.2005.07.004. Epub 2005 Sep 28. PubMed PMID: 16198134. See more on PubMed
  • Cagnacci A, Arangino S, Caretto S, Mazza V, Volpe A. Sexual dimorphism in the levels of amniotic fluid leptin in pregnancies at 16 weeks of gestation: relation to fetal growth. Eur J Obstet Gynecol Reprod Biol. 2006 Jan 1;124(1):53-7. doi: 10.1016/j.ejogrb.2005.05.009. Epub 2005 Jul 26. PubMed PMID: 16051417. See more on PubMed
  • Pilz S, Horejsi R, Möller R, Almer G, Scharnagl H, Stojakovic T, Dimitrova R, Weihrauch G, Borkenstein M, Maerz W, Schauenstein K, Mangge H. Early atherosclerosis in obese juveniles is associated with low serum levels of adiponectin. J Clin Endocrinol Metab. 2005 Aug;90(8):4792-6. doi: 10.1210/jc.2005-0167. Epub 2005 May 31. PubMed PMID: 15928248. See more on PubMed
  • Housová J, Wilczek H, Haluzík MM, Kremen J, Krízová J, Haluzík M. Adipocyte-derived hormones in heroin addicts: the influence of methadone maintenance treatment. Physiol Res. 2005;54(1):73-78. doi: 10.33549/physiolres.930568. PubMed PMID: 15717844. See more on PubMed
  • Stejskal D, Stejskal P, Růzicka V, Jedelský L, Horalík D, Kalina M, Bartek J. [Leptinaemia in the Czech population]. Vnitr Lek. 1999 Mar;45(3):139-47. PubMed PMID: 15641235. See more on PubMed
  • Kalousová M, Zima T, Popov P, Spacek P, Braun M, Soukupová J, Pelinkova K, Kientsch-Engel R. Advanced glycation end-products in patients with chronic alcohol misuse. Alcohol Alcohol. 2004 Jul-Aug;39(4):316-20. doi: 10.1093/alcalc/agh058. PubMed PMID: 15208163. See more on PubMed
  • Meier U, Gressner AM. Endocrine regulation of energy metabolism: review of pathobiochemical and clinical chemical aspects of leptin, ghrelin, adiponectin, and resistin. Clin Chem. 2004 Sep;50(9):1511-25. doi: 10.1373/clinchem.2004.032482. Epub 2004 Jul 20. PubMed PMID: 15265818. See more on PubMed
  • Welt CK, Schneyer AL, Heist K, Mantzoros CS. Leptin and soluble leptin receptor in follicular fluid. J Assist Reprod Genet. 2003 Dec;20(12):495-501. doi: 10.1023/b:jarg.0000013649.38415.2a. PubMed PMID: 15035548. PubMed CentralPMCID: PMC3455309. See more on PubMed
  • Krsek M, Silha JV, Jezková J, Hána V, Marek J, Weiss V, Stepán JJ, Murphy LJ. Adipokine levels in Cushing's syndrome; elevated resistin levels in female patients with Cushing's syndrome. Clin Endocrinol (Oxf). 2004 Mar;60(3):350-7. doi: 10.1111/j.1365-2265.2003.01987.x. PubMed PMID: 15009001. See more on PubMed
  • Krízová J, Sulková S, Bednárová V, Parízková J, Kotrlíková E, Haluzík M. Soluble leptin receptor levels in patients with chronic renal failure. Physiol Res. 2003;52(3):347-51. PubMed PMID: 12790767. See more on PubMed
  • Teplan V, Schück O, Stollová M, Vítko S. Obesity and hyperhomocysteinaemia after kidney transplantation. Nephrol Dial Transplant. 2003 Jul;18 Suppl 5:v71-3. doi: 10.1093/ndt/gfg1053. PubMed PMID: 12817077. See more on PubMed
  • Ruffingshofer D, Endemann M, Arbeiter K, Bidmon B, Mueller T, Herkner K, Aufricht C. Induction of heat shock protein 72 in mesothelial cells exposed to peritoneal dialysate effluent. Perit Dial Int. 2003 Jan-Feb;23(1):74-7. PubMed PMID: 12691510. See more on PubMed
  • Haluzik M, Markova M, Slaby JJ, Jiskra J, Krizova J, Hass T. The changes of serum leptin and soluble leptin receptor levels in patients undergoing mobilization of peripheral blood stem cells before autologous stem cells transplantation. Endocr Res. 2002 Aug;28(3):189-97. doi: 10.1081/erc-120015057. PubMed PMID: 12489568. See more on PubMed
  • Krsek M, Rosická M, Haluzík M, Svobodová J, Kotrlíková E, Justová V, Lacinová Z, Jarkovská Z. Plasma ghrelin levels in patients with short bowel syndrome. Endocr Res. 2002 Feb-May;28(1-2):27-33. doi: 10.1081/erc-120004535. PubMed PMID: 12108787. See more on PubMed
  • Lichnovská R, Gwozdziewiczová S, Hrebícek J. Gender differences in factors influencing insulin resistance in elderly hyperlipemic non-diabetic subjects. Cardiovasc Diabetol. 2002 Oct 14;1:4. doi: 10.1186/1475-2840-1-4. PubMed PMID: 12423554. PubMed CentralPMCID: PMC140144. See more on PubMed
  • van Dielen FM, van't Veer C, Schols AM, Soeters PB, Buurman WA, Greve JW. Increased leptin concentrations correlate with increased concentrations of inflammatory markers in morbidly obese individuals. Int J Obes Relat Metab Disord. 2001 Dec;25(12):1759-66. doi: 10.1038/sj.ijo.0801825. PubMed PMID: 11781755. See more on PubMed
  • van Dielen FM, van 't Veer C, Buurman WA, Greve JW. Leptin and soluble leptin receptor levels in obese and weight-losing individuals. J Clin Endocrinol Metab. 2002 Apr;87(4):1708-16. doi: 10.1210/jcem.87.4.8381. PubMed PMID: 11932305. See more on PubMed
  • Haluzík M, Sindelka G, Widimský J Jr, Prázný M, Zelinka T, Skrha J. Serum leptin levels in patients with primary hyperaldosteronism before and after treatment: relationships to insulin sensitivity. J Hum Hypertens. 2002 Jan;16(1):41-5. doi: 10.1038/sj.jhh.1001292. PubMed PMID: 11840228. See more on PubMed
  • Adam JA, Menheere PP, van Dielen FM, Soeters PB, Buurman WA, Greve JW. Decreased plasma orexin-A levels in obese individuals. Int J Obes Relat Metab Disord. 2002 Feb;26(2):274-6. doi: 10.1038/sj.ijo.0801868. PubMed PMID: 11850761. See more on PubMed
  • Hrebícek J, Janout V, Malincíková J, Horáková D, Cízek L. Detection of insulin resistance by simple quantitative insulin sensitivity check index QUICKI for epidemiological assessment and prevention. J Clin Endocrinol Metab. 2002 Jan;87(1):144-7. doi: 10.1210/jcem.87.1.8292. PubMed PMID: 11788638. See more on PubMed
  • Haluzík M, Matoulek M, Svacina S, Hilgertová J, Haas T. The influence of short-term fasting on serum leptin levels, and selected hormonal and metabolic parameters in morbidly obese and lean females. Endocr Res. 2001 Feb-May;27(1-2):251-60. doi: 10.1081/erc-100107185. PubMed PMID: 11428717. See more on PubMed
  • Marková M, Haluzík M, Svobodová J, Rosická M, Nedvídková J, Haas T. Serum leptin levels in patients with sideropenic and pernicious anemia: the influence of anemia treatment. Physiol Res. 2000;49(6):679-84. PubMed PMID: 11252534. See more on PubMed
  • Creutzberg EC, Wouters EF, Vanderhoven-Augustin IM, Dentener MA, Schols AM. Disturbances in leptin metabolism are related to energy imbalance during acute exacerbations of chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2000 Oct;162(4 Pt 1):1239-45. doi: 10.1164/ajrccm.162.4.9912016. PubMed PMID: 11029324. See more on PubMed
  • Malincíková J, Stejskal D, Hrebícek J. Serum leptin and leptin receptors in healthy prepubertal children: relations to insulin resistance and lipid parameters, body mass index (BMI), tumor necrosis factor alpha (TNF alpha), heart fatty acid binding protein (hFABP), and IgG anticardiolipin (ACL-IgG). Acta Univ Palacki Olomuc Fac Med. 2000;143:51-7. doi: 10.5507/bp.2000.007. PubMed PMID: 11144119. See more on PubMed
  • Haluzík M, Fiedler J, Nedvídková J, Ceska R. Serum leptin levels in patients with hyperlipidemias. Nutrition. 2000 Jun;16(6):429-33. doi: 10.1016/s0899-9007(00)00288-4. PubMed PMID: 10869898. See more on PubMed
  • Stejskal D, Bartek J, Růzicka V, Stejskal P, Jedelský L, Oral I, Horalík D, Zurek M. Determination of leptin receptor in the serum and relations to laboratory and anthropological parameters in patients with atherosclerotic complications. Acta Univ Palacki Olomuc Fac Med. 1999;142:89-92. PubMed PMID: 10743733. See more on PubMed
Summary References (20)

References to Leptin

  • Auwerx J, Staels B. Leptin (Review article). The Lancet . 13, 737 (1998);
  • Blum WF, Englaro P, Hanitsch S, Juul A, Hertel NT, Muller J, Skakkebaek NE, Heiman ML, Birkett M, Attanasio AM, Kiess W, Rascher W. Plasma leptin levels in healthy children and adolescents: dependence on body mass index, body fat mass, gender, pubertal stage, and testosterone. J Clin Endocrinol Metab. 1997 Sep;82 (9):2904-10
  • Chehab FF, Mounzih K, Lu R, Lim ME. Early onset of reproductive function in normal female mice treated with leptin. Science. 1997 Jan 3;275 (5296):88-90
  • Clement K, Vaisse C, Lahlou N, Cabrol S, Pelloux V, Cassuto D, Gourmelen M, Dina C, Chambaz J, Lacorte JM, Basdevant A, Bougneres P, Lebouc Y, Froguel P, Guy-Grand B. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature. 1998 Mar 26;392 (6674):398-401
  • Cohen B, Novick D, Rubinstein M. Modulation of insulin activities by leptin. Science. 1996 Nov 15;274 (5290):1185-8
  • Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, Ohannesian JP, Marco CC, McKee LJ, Bauer TL, et al. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med. 1996 Feb 1;334 (5):292-5
  • Friedman JM, Halaas JL. Leptin and the regulation of body weight in mammals. Nature. 1998 Oct 22;395 (6704):763-70
  • Halaas JL, Gajiwala KS, Maffei M, Cohen SL, Chait BT, Rabinowitz D, Lallone RL, Burley SK, Friedman JM. Weight-reducing effects of the plasma protein encoded by the obese gene. Science. 1995 Jul 28;269 (5223):543-6
  • Harigaya A, Nagashima K, Nako Y, Morikawa A. Relationship between concentration of serum leptin and fetal growth. J Clin Endocrinol Metab. 1997 Oct;82 (10):3281-4
  • Lonnqvist F, Arner P, Nordfors L, Schalling M. Overexpression of the obese (ob) gene in adipose tissue of human obese subjects. Nat Med. 1995 Sep;1 (9):950-3
  • Maffei M, Halaas J, Ravussin E, Pratley RE, Lee GH, Zhang Y, Fei H, Kim S, Lallone R, Ranganathan S, et al. Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med. 1995 Nov;1 (11):1155-61
  • Montague CT, Farooqi IS, Whitehead JP, Soos MA, Rau H, Wareham NJ, Sewter CP, Digby JE, Mohammed SN, Hurst JA, Cheetham CH, Earley AR, Barnett AH, Prins JB, O'Rahilly S. Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature. 1997 Jun 26;387 (6636):903-8
  • Pelleymounter MA, Cullen MJ, Baker MB, Hecht R, Winters D, Boone T, Collins F. Effects of the obese gene product on body weight regulation in ob/ob mice. Science. 1995 Jul 28;269 (5223):540-3
  • Ricci MR, Lee MJ, Russell CD, Wang Y, Sullivan S, Schneider SH, Brolin RE, Fried SK. Isoproterenol decreases leptin release from rat and human adipose tissue through posttranscriptional mechanisms. Am J Physiol Endocrinol Metab. 2005 Apr;288 (4):E798-804
  • Schubring C, Prohaska F, Prohaska A, Englaro P, Blum W, Siebler T, Kratzsch J, Kiess W. Leptin concentrations in maternal serum and amniotic fluid during the second trimenon: differential relation to fetal gender and maternal morphometry. Eur J Obstet Gynecol Reprod Bi. 1999 Oct;86 (2):151-7
  • Spiegelman BM, Flier JS. Adipogenesis and obesity: rounding out the big picture. Cell. 1996 Nov 1;87 (3):377-89
  • Tartaglia LA. The leptin receptor. J Biol Chem. 1997 Mar 7;272 (10):6093-6
  • Tritos NA, Mantzoros CS. Leptin: its role in obesity and beyond. Diabetologia. 1997 Dec;40 (12):1371-9
  • Zhang F, Basinski MB, Beals JM, Briggs SL, Churgay LM, Clawson DK, DiMarchi RD, Furman TC, Hale JE, Hsiung HM, Schoner BE, Smith DP, Zhang XY, Wery JP, Schevitz RW. Crystal structure of the obese protein leptin-E100. Nature. 1997 May 8;387 (6629):206-9
  • Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature. 1994 Dec 1;372 (6505):425-32
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