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PYY Rat ELISA

  • Regulatory status:RUO
  • Type:Competitive ELISA, Immobilized antibody
  • Other names:Peptide YY
  • Species:Rat
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RSCYK081R 96 wells (1 kit)
PubMed Product Details
Technical Data

Type

Competitive ELISA, Immobilized antibody

Applications

Plasma

Sample Requirements

25 µl/well

Shipping

At ambient temperature. Upon receipt, store the product at the temperature recommended below.

Storage/Expiration

Store the complete kit at 2–8°C. Under these conditions, the kit is stable until the expiration date (see label on the box).

Calibration Curve

Calibration Range

0.15–12,5 ng/ml

Intra-assay (Within-Run)

CV = 3,1 - 9,8 %

Inter-assay (Run-to-Run)

CV = 4,2 - 14,2%

Summary

Research topic

Energy metabolism and body weight regulation, Animal studies

Summary

PYY was isolated initially by Tatemoto et al. (1980) from the extract of pig duodenum and shown to be a polypeptide consisting of 36 amino acids residues. PYY is homologous to pancreatic polypeptide (PP) and neuropeptide Y (NPY). PYY is localized mainly in endocrine cells in the intestine (ileum, colon, and rectum). PYY shows an inhibitory action on contraction of the gastrointestinal tract and on secretion of pancreatic and gastric juice. PYY is released by taking diet. The PYY level decreases after resection of the intestine, possiblly be due to the decrease in number of the endocrine cells secreting PYY.

References to Product

References

  • Adrian, T.E., Smith, H.A, Calvert, S.A., Aynsley-Green, A. and Bloom, S.R.: Elevated plasma peptide YY in human neonates and infants. Pediatric Research, 20:1225 -1227. 1986
  • Adrian T.E., Ferri, G.L., Bacarese-Hamilton, A.J., Fuessl, H.S., Polak, J.M. and Bloom, S.R.: Human distribution and release of a putative new gut hormone, peptide YY. Gastroenterology, 89:1070-1077. 1995
  • El-Salhy, M., Grimelius, L., Wilander, E ., Ryberg B., Terenius, L., Lundburg, J.M. and Tatemoto, K.: Immunocytochemical identification of polypeptide YY (PYY) cells in the human gastrointestinal tract. Histochemistry, 77:15-23. 1983
  • Greeley, G.H. Jr., Hashimoto, T., Izukura, M., Gomez, G., Jeng, J. Hill, F.L.C., Liuis, F., and Thompson, J.C.: A comparison of intraduodenally and intracolonically administered nutrients on the release of peptide YY in the dog. Endocrinology, 125:1761 -1765. 1989
  • Greeley, G.H. Jr., Hill, F. L. C., Spannagel, A. and Thompson, J.C.: Distribution of peptide YY in gastrointestinal tract of the rat dog, and monkey. Regulated Peptides, 19, 365-372. 1987 ¨- Gomez, G., Zhang, T., Rajaraman, S., Thakore, K.N., Yanaihara, N., Townsend C.M. Jr., Thompson, J.C. and Greeley, G.H. Jr.: Intestinal peptide YY : ontogeny of gene expression in rat bowel and trophic action on rat and mouse bowel. American Journal Physiology. 268, G71-G81. 1995
  • Larhammar, D.: Evolution of neuropeptide Y, peptide YY and pancreatic polypeptide: Regulated Peptides, 62, 1-11. 1996
  • National Committee for Clinical Laboratory Standards Evaluation Protocols, SC1, (1989), Vallanova, PA: NCCLS
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