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Manufactured by BioVendor

21-Hydroxylase (21-OH) Autoantibody ELISA

  • Regulatory status:RUO
  • Type:Sandwich ELISA, Biotin-labelled antibody
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Cat. No. Size Price


R21E/96R 96 wells (1 kit)
PubMed Product Details
Technical Data

Type

Sandwich ELISA, Biotin-labelled antibody

Applications

Serum

Sample Requirements

50 μl/well

Shipping

At ambient temperature. Upon receipt, store the product at the temperature recommended below.

Storage/Expiration

Store the complete kit at 2–8°C. Under these conditions, the kit is stable until the expiration date (see label on the box).

Calibration Range

100-0,3 u/ml

Limit of Detection

0,13 u/ml

Intra-assay (Within-Run)

4,8 %

Inter-assay (Run-to-Run)

6,2 %

Summary

Research topic

Autoimmunity

Summary

Autoimmune destruction of the adrenal cortex is the most common cause of Addison’s disease and autoantibodies to the adrenal specific enzyme steroid 21-OH hydroxylase are important markers of adrenal autoimmunity. This can be the case if the disease presents as Addison’s disease or as part of the autoimmune polyglandular syndromes (APS) type I or type II.

Product References (5)

References

  • Husebye ES, Allolio B, Arlt W, Badenhoop K, Bensing S, Betterle C, Falorni A, Gan EH, Hulting AL, Kasperlik-Zaluska A, Kämpe O, Løvås K, Meyer G, Pearce SH.Consensus statement on the diagnosis, treatment and follow-up of patients withprimary adrenal insufficiency. J Intern Med. 2014 Feb;275(2):104-15. doi:10.1111/joim.12162. Epub 2013 Dec 16. Review. PubMed PMID: 24330030. See more on PubMed
  • Coco G, Dal Pra C, Presotto F, Albergoni MP, Canova C, Pedini B, Zanchetta R, Chen S, Furmaniak J, Rees Smith B, Mantero F, Betterle C. Estimated risk fordeveloping autoimmune Addison's disease in patients with adrenal cortexautoantibodies. J Clin Endocrinol Metab. 2006 May;91(5):1637-45. Epub 2006 Mar 7.PubMed PMID: 16522688. See more on PubMed
  • Tanaka H, Perez MS, Powell M, Sanders JF, Sawicka J, Chen S, Prentice L, AsawaT, Betterle C, Volpato M, Smith BR, Furmaniak J. Steroid 21-hydroxylaseautoantibodies: measurements with a new immunoprecipitation assay. J ClinEndocrinol Metab. 1997 May;82(5):1440-6. PubMed PMID: 9141530. See more on PubMed
  • Smith BR, Furmaniak J. Adrenal and gonadal autoimmune diseases. J ClinEndocrinol Metab. 1995 May;80(5):1502-5. Review. PubMed PMID: 7744992. See more on PubMed
  • Chen S, Sawicka J, Betterle C, Powell M, Prentice L, Volpato M, Rees Smith B, Furmaniak J. Autoantibodies to steroidogenic enzymes in autoimmune polyglandular syndrome, Addison's disease, and premature ovarian failure. J Clin EndocrinolMetab. 1996 May;81(5):1871-6. PubMed PMID: 8626850. See more on PubMed
Summary References (1)

References to 21-hydroxylase

  • Smith BR, Furmaniak J. Adrenal and gonadal autoimmune diseases. J Clin Endocrinol Metab. 1995 May;80 (5):1502-5
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