Select country change
Shopping cart (0 , 0,00 ) Menu Search
Manufactured by BioVendor

Adiponectin Human ELISA (Competitive)

  • Regulatory status:RUO
  • Type:Competitive ELISA, Immobilized antigen
  • Other names:Adipocyte C1q and collagen domain-containing protein, Adipocyte complement-related 30 kDa protein, ACRP30, Adipose most abundant gene transcript 1 protein, apM-1, Gelatin-binding protein, ADIPOQ, ACDC, APM1, GBP28
  • Species:Human
Please select your region to see available products and prices.
Cat. No. Size Price


RD195023100 96 wells (1 kit)
PubMed Product Details
Technical Data

Type

Competitive ELISA, Immobilized antigen

Applications

Serum, Plasma-EDTA, Plasma-Heparin, Plasma-Citrate

Sample Requirements

10 µl/well

Shipping

At ambient temperature. Upon receipt, store the product at the temperature recommended below.

Storage/Expiration

Store the kit at 2–8°C. Under these conditions, assay components are stable till the expiry date is over. (See the expiry date indicated on the kit label).

Calibration Curve

Calibration Range

0.1–10 µg/ml

Limit of Detection

26 ng/ml

Intra-assay (Within-Run)

n = 8; CV = 4.9%

Inter-assay (Run-to-Run)

n = 8; CV = 6.7%

Spiking Recovery

100,20%

Dilutation Linearity

99,90%

Crossreactivity

  • bovine Non-detectable
  • cat Non-detectable
  • dog Non-detectable
  • goat Non-detectable
  • hamster Non-detectable
  • horse Non-detectable
  • mouse Non-detectable
  • pig Non-detectable
  • rabbit Non-detectable
  • rat Non-detectable
  • sheep Non-detectable
  • chicken Not tested
  • human Yes
  • monkey Yes (recommended dilution 1:30)
Summary

Features

  • European Union: for in vitro diagnostic use
  • Rest of the world: for research use only!
  • The total assay time is less than 3 hours
  • The kit measures total adiponectin in serum and plasma (EDTA, citrate, heparin)
  • Assay format is 96 wells
  • Quality Controls are human serum based
  • Standards are recombinant adiponectin based
  • Components of the kit are provided ready to use or concentrated

Research topic

Chronic renal failure, Coronary artery disease, Diabetology - Other Relevant Products, Energy metabolism and body weight regulation

Summary

Adiponectin, also referred to as Acrp30, AdipoQ and GBP-28, is a recently discovered 244 aminoacid protein, the product of the apM1 gene, which is physiologically active and specifically and highly expressed in adipose cells. The protein belongs to the soluble defence collagen superfamily; it has a collagen-like domain structurally homologous with collagen VIII and X and complement factor C1q-like globular domain. Adiponectin forms homotrimers, which are the building blocks for higher order complexes found circulating in serum. Together, these complexes make up approximately 0.01% of total serum protein. Adiponectin receptors AdipoR1 and AdipoR2 have been recently cloned; AdipoR1 is abundantly expressed in skeletal muscle, whereas AdipoR2 is predominantly expressed in the liver. Paradoxically, adipose tissue-expressed adiponectin levels are inversely related to the degree of adiposity. Adiponectin concentrations correlate negatively with glucose, insulin, triglyceride concentrations, liver fat content and body mass index and positively with high-density lipoprotein-cholesterol levels, hepatic insulin sensitivity and insulin-stimulated glucose disposal. Adiponectin has been shown to increase insulin sensitivity and decrease plasma glucose by increasing tissue fat oxidation. Of particular interest is that low adiponectin serum levels predict type 2 diabetes independent of other risk factors. Adiponectin also inhibits the inflammatory processes of atherosclerosis suppressing the expression of adhesion and cytokine molecules in vascular endothelial cells and macrophages, respectively. This adipokine plays a role as a scaffold of newly formed collagen in myocardial remodelling after ischaemic injury and also stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signalling in endothelial cells. Low serum adiponectin levels are found in patients with coronary artery disease. Moreover, high circulating levels of adiponectin are associated with decreased risk of myocardial infarction, independent of other factors. Altogether, adiponectin has the potential to become a clinically relevant parameter to be measured routinely in subjects at risk for type 2 diabetes, atherosclerosis and the metabolic syndrome.

Product References (74)

References

  • Annuzzi G, Bozzetto L, Patti L, Santangelo C, Giacco R, Di Marino L, De NataleC, Masella R, Riccardi G, Rivellese AA. Type 2 diabetes mellitus is characterizedby reduced postprandial adiponectin response: a possible link with diabeticpostprandial dyslipidemia. Metabolism. 2010 Apr;59(4):567-74. doi:10.1016/j.metabol.2009.08.020. Epub 2009 Nov 18. PubMed PMID: 19922965. See more on PubMed
  • Antonopoulos AS, Tousoulis D, Antoniades C, Miliou A, Hatzis G, PapageorgiouN, Demosthenous M, Tentolouris C, Stefanadis C. Genetic variability onadiponectin gene affects myocardial infarction risk: the role of endothelialdysfunction. Int J Cardiol. 2013 Sep 20;168(1):326-30. doi:10.1016/j.ijcard.2012.09.053. Epub 2012 Oct 4. PubMed PMID: 23041095. See more on PubMed
  • Arzola-Paniagua MA, García-Salgado López ER, Calvo-Vargas CG, Guevara-Cruz M. Efficacy of an orlistat-resveratrol combination for weight loss in subjects with obesity: A randomized controlled trial. Obesity (Silver Spring). 2016Jul;24(7):1454-63. doi: 10.1002/oby.21523. Epub 2016 May 25. PubMed PMID:27221771. See more on PubMed
  • Avignon A, Sultan A, Piot C, Elaerts S, Cristol JP, Dupuy AM. Osteoprotegerin is associated with silent coronary artery disease in high-risk but asymptomatictype 2 diabetic patients. Diabetes Care. 2005 Sep;28(9):2176-80. PubMed PMID:16123486. See more on PubMed
  • Avignon A, Sultan A, Piot C, Mariano-Goulart D, Thuan Dit Dieudonné JF,Cristol JP, Dupuy AM. Osteoprotegerin: a novel independent marker for silentmyocardial ischemia in asymptomatic diabetic patients. Diabetes Care. 2007Nov;30(11):2934-9. Epub 2007 Aug 21. PubMed PMID: 17712025. See more on PubMed
  • Baranova A, Gowder SJ, Schlauch K, Elariny H, Collantes R, Afendy A, Ong JP,Goodman Z, Chandhoke V, Younossi ZM. Gene expression of leptin, resistin, andadiponectin in the white adipose tissue of obese patients with non-alcoholicfatty liver disease and insulin resistance. Obes Surg. 2006 Sep;16(9):1118-25.PubMed PMID: 16989692. See more on PubMed
  • Behrouz V, Jazayeri S, Aryaeian N, Zahedi MJ, Hosseini F. Effects of Probioticand Prebiotic Supplementation on Leptin, Adiponectin, and Glycemic Parameters in Non-alcoholic Fatty Liver Disease: A Randomized Clinical Trial. Middle East J DigDis. 2017 Jul;9(3):150-157. doi: 10.15171/mejdd.2017.66. PubMed PMID: 28894517;PubMed Central PMCID: PMC5585907. See more on PubMed
  • Benedict C, Kern W, Schultes B, Born J, Hallschmid M. Differential sensitivityof men and women to anorexigenic and memory-improving effects of intranasalinsulin. J Clin Endocrinol Metab. 2008 Apr;93(4):1339-44. doi:10.1210/jc.2007-2606. Epub 2008 Jan 29. PubMed PMID: 18230654. See more on PubMed
  • Bersinger NA, Birkhäuser MH, Wunder DM. Adiponectin as a marker of success in intracytoplasmic sperm injection/embryo transfer cycles. Gynecol Endocrinol. 2006Sep;22(9):479-83. PubMed PMID: 17071530. See more on PubMed
  • Bobbert T, Rochlitz H, Wegewitz U, Akpulat S, Mai K, Weickert MO, Möhlig M,Pfeiffer AF, Spranger J. Changes of adiponectin oligomer composition by moderate weight reduction. Diabetes. 2005 Sep;54(9):2712-9. PubMed PMID: 16123361. See more on PubMed
  • Cabré A, Lázaro I, Girona J, Manzanares J, Marimón F, Plana N, Heras M, MasanaL. Retinol-binding protein 4 as a plasma biomarker of renal dysfunction andcardiovascular disease in type 2 diabetes. J Intern Med. 2007 Oct;262(4):496-503.PubMed PMID: 17875187. See more on PubMed
  • Catalán V, Gómez-Ambrosi J, Pastor C, Rotellar F, Silva C, Rodríguez A, GilMJ, Cienfuegos JA, Salvador J, Vendrell J, Frühbeck G. Influence of morbidobesity and insulin resistance on gene expression levels of AQP7 in visceraladipose tissue and AQP9 in liver. Obes Surg. 2008 Jun;18(6):695-701. doi:10.1007/s11695-008-9453-7. Epub 2008 Apr 10. PubMed PMID: 18401671. See more on PubMed
  • Catalán V, Gómez-Ambrosi J, Ramirez B, Rotellar F, Pastor C, Silva C,Rodríguez A, Gil MJ, Cienfuegos JA, Frühbeck G. Proinflammatory cytokines inobesity: impact of type 2 diabetes mellitus and gastric bypass. Obes Surg. 2007Nov;17(11):1464-74. PubMed PMID: 18219773. See more on PubMed
  • Catalán V, Gómez-Ambrosi J, Rodríguez A, Silva C, Rotellar F, Gil MJ,Cienfuegos JA, Salvador J, Frühbeck G. Expression of caveolin-1 in human adipose tissue is upregulated in obesity and obesity-associated type 2 diabetes mellitus and related to inflammation. Clin Endocrinol (Oxf). 2008 Feb;68(2):213-9. Epub2007 Sep 4. PubMed PMID: 17803693. See more on PubMed
  • Catalán V, Gómez-Ambrosi J, Rotellar F, Silva C, Gil MJ, Rodríguez A,Cienfuegos JA, Salvador J, Frühbeck G. The obestatin receptor (GPR39) isexpressed in human adipose tissue and is down-regulated in obesity-associatedtype 2 diabetes mellitus. Clin Endocrinol (Oxf). 2007 Apr;66(4):598-601. PubMedPMID: 17371481. See more on PubMed
  • Delfini E, Petramala L, Caliumi C, Cotesta D, De Toma G, Cavallaro G,Panzironi G, Diacinti D, Minisola S, D' Erasmo E, Mazzuoli GF, Letizia C.Circulating leptin and adiponectin levels in patients with primaryhyperparathyroidism. Metabolism. 2007 Jan;56(1):30-6. PubMed PMID: 17161223. See more on PubMed
  • Dieplinger B, Poelz W, Haltmayer M, Mueller T. Association of adiponectin and amino terminal proBNP in peripheral arterial disease. Clin Chim Acta. 2007Feb;377(1-2):192-7. Epub 2006 Sep 30. PubMed PMID: 17112494. See more on PubMed
  • Dieplinger B, Poelz W, Haltmayer M, Mueller T. Hypoadiponectinemia isassociated with symptomatic atherosclerotic peripheral arterial disease. ClinChem Lab Med. 2006;44(7):830-3. PubMed PMID: 16776628. See more on PubMed
  • Giri S, Rattan R, Haq E, Khan M, Yasmin R, Won JS, Key L, Singh AK, Singh I.AICAR inhibits adipocyte differentiation in 3T3L1 and restores metabolicalterations in diet-induced obesity mice model. Nutr Metab (Lond). 2006 Aug10;3:31. PubMed PMID: 16901342; PubMed Central PMCID: PMC1564022. See more on PubMed
  • Golledge J, Jayalath R, Oliver L, Parr A, Schurgers L, Clancy P. Relationship between CT anthropometric measurements, adipokines and abdominal aorticcalcification. Atherosclerosis. 2008 Mar;197(1):428-34. Epub 2007 Aug 6. PubMedPMID: 17675038; PubMed Central PMCID: PMC2288671. See more on PubMed
  • Gómez-Ambrosi J, Catalán V, Ramírez B, Rodríguez A, Colina I, Silva C,Rotellar F, Mugueta C, Gil MJ, Cienfuegos JA, Salvador J, Frühbeck G. Plasmaosteopontin levels and expression in adipose tissue are increased in obesity. JClin Endocrinol Metab. 2007 Sep;92(9):3719-27. Epub 2007 Jun 26. PubMed PMID:17595250. See more on PubMed
  • Gumanova NG, Gavrilova NE, Chernushevich OI, Kots AY, Metelskaya VA. Ratios ofleptin to insulin and adiponectin to endothelin are sex-dependently associatedwith extent of coronary atherosclerosis. Biomarkers. 2017 May -Jun;22(3-4):239-245. doi: 10.1080/1354750X.2016.1201539. Epub 2016 Jun 30. PubMedPMID: 27300270. See more on PubMed
  • Chalvatzas N, Dafopoulos K, Kosmas G, Kallitsaris A, Pournaras S, Messinis IE.Effect of ovarian hormones on serum adiponectin and resistin concentrations.Fertil Steril. 2009 Apr;91(4):1189-94. doi: 10.1016/j.fertnstert.2008.01.027.Epub 2008 Mar 5. PubMed PMID: 18325516. See more on PubMed
  • Chu MC, Cosper P, Orio F, Carmina E, Lobo RA. Insulin resistance inpostmenopausal women with metabolic syndrome and the measurements of adiponectin,leptin, resistin, and ghrelin. Am J Obstet Gynecol. 2006 Jan;194(1):100-4. PubMedPMID: 16389017. See more on PubMed
  • Jang HB, Kim HJ, Kang JH, Park SI, Park KH, Lee HJ. Association of circulatingirisin levels with metabolic and metabolite profiles of Korean adolescents.Metabolism. 2017 Aug;73:100-108. doi: 10.1016/j.metabol.2017.05.007. Epub 2017May 31. PubMed PMID: 28732566. See more on PubMed
  • Kajiya T, Er BH, Chan MY, Low AF, Tan HC, Tai BC, Lee CH. Paradoxical effects of adiponectin level on plaque vulnerability and clinical outcomes after coronaryrevascularization. Int J Cardiol. 2013 Oct 12;168(5):4796-8. doi:10.1016/j.ijcard.2013.07.043. Epub 2013 Jul 22. PubMed PMID: 23886528. See more on PubMed
  • Karaduman M, Sengul A, Oktenli C, Pekel A, Yesilova Z, Musabak U, SanisogluSY, Gunay C, Baysan O, Kocar IH, Tatar H, Ozata M. Tissue levels of adiponectin, tumour necrosis factor-alpha, soluble intercellular adhesion molecule-1 andheart-type fatty acid-binding protein in human coronary atherosclerotic plaques. Clin Endocrinol (Oxf). 2006 Feb;64(2):196-202. PubMed PMID: 16430720. See more on PubMed
  • Khosrowbeygi A, Ahmadvand H. Maternal serum levels of adiponectin inpreeclampsia. J Ayub Med Coll Abbottabad. 2009 Jul-Sep;21(3):79-82. PubMed PMID: 20929020. See more on PubMed
  • Khosrowbeygi A, Rezvanfar MR, Ahmadvand H. Tumor necrosis factor- α,adiponectin and their ratio in gestational diabetes mellitus. Caspian J InternMed. 2018 Winter;9(1):71-79. doi: 10.22088/cjim.9.1.71. PubMed PMID: 29387323;PubMed Central PMCID: PMC5771364. See more on PubMed
  • Koleva DI, Orbetzova MM, Nikolova JG, Tyutyundzhiev SB. Adipokines and solublecell adhesion molecules in insulin resistant and non-insulin resistant women withpolycystic ovary syndrome. Arch Physiol Biochem. 2016 Oct;122(4):223-227. Epub2016 May 31. PubMed PMID: 27245110. See more on PubMed
  • Krusinová E, Klementová M, Kopecký J, Wohl P, Kazdová L, Mlejnek P, PravenecM, Hill M, Pelikánová T. Effect of acute hyperinsulinaemia with and withoutangiotensin II type 1 receptor blockade on resistin and adiponectinconcentrations and expressions in healthy subjects. Eur J Endocrinol. 2007Oct;157(4):443-9. PubMed PMID: 17893258. See more on PubMed
  • Lamounier-Zepter V, Bornstein SR, Kunes J, Zicha J, Krsek M, Ehrhart-BornsteinM, Ziegler CG, Kiessling A, Funk RH, Haluzik M. Adrenocortical changes andarterial hypertension in lipoatrophic A-ZIP/F-1 mice. Mol Cell Endocrinol. 2008Jan 2;280(1-2):39-46. Epub 2007 Oct 18. PubMed PMID: 18045774. See more on PubMed
  • Leutner M, Göbl C, Wolf P, Maruszczak K, Bozkurt L, Steinbrecher H,Just-Kukurova I, Ott J, Egarter C, Trattnig S, Kautzky-Willer A. Pericardial Fat Relates to Disturbances of Glucose Metabolism in Women with the Polycystic Ovary Syndrome, but Not in Healthy Control Subjects. Int J Endocrinol. 2018 Aug7;2018:5406128. doi: 10.1155/2018/5406128. eCollection 2018. PubMed PMID:30158974; PubMed Central PMCID: PMC6109482. See more on PubMed
  • Lu Y, Andiappan AK, Lee B, Ho R, Lim TK, Kuan WS, Goh DY, Mahadevan M, Sim TB,Wang Y, Van Bever HP, Rotzschke O, Larbi A, Ng TP. Neuropeptide Y associated withasthma in young adults. Neuropeptides. 2016 Oct;59:117-121. doi:10.1016/j.npep.2016.07.003. Epub 2016 Jul 20. PubMed PMID: 27469060. See more on PubMed
  • Luque-Ramírez M, Martínez-García MÁ, Montes-Nieto R, Fernández-Durán E,Insenser M, Alpañés M, Escobar-Morreale HF. Sexual dimorphism in adipose tissuefunction as evidenced by circulating adipokine concentrations in the fastingstate and after an oral glucose challenge. Hum Reprod. 2013 Jul;28(7):1908-18.doi: 10.1093/humrep/det097. Epub 2013 Apr 4. PubMed PMID: 23559188. See more on PubMed
  • Mangge H, Freytag F, Almer G, Weghuber D, Bauer-Denk C, Fuchs D. Serumneopterin is not increased in obese juveniles. J Obes. 2011;2011:946795. doi:10.1155/2011/946795. Epub 2011 Jan 12. PubMed PMID: 21274279; PubMed CentralPMCID: PMC3025381. See more on PubMed
  • Marinoni E, Letizia C, Ciardo F, Corona G, Moscarini M, Di Iorio R. Effects ofprenatal betamethasone administration on leptin and adiponectin concentrations inmaternal and fetal circulation. Am J Obstet Gynecol. 2008 Aug;199(2):141.e1-6.doi: 10.1016/j.ajog.2008.02.047. Epub 2008 May 23. PubMed PMID: 18456235. See more on PubMed
  • Mente A, Razak F, Blankenberg S, Vuksan V, Davis AD, Miller R, Teo K, GersteinH, Sharma AM, Yusuf S, Anand SS; Study of the Health Assessment And RiskEvaluation; Study of the Health Assessment And Risk Evaluation in AboriginalPeoples Investigators. Ethnic variation in adiponectin and leptin levels andtheir association with adiposity and insulin resistance. Diabetes Care. 2010Jul;33(7):1629-34. doi: 10.2337/dc09-1392. Epub 2010 Apr 22. PubMed PMID:20413520; PubMed Central PMCID: PMC2890372. See more on PubMed
  • Möhlig M, Freudenberg M, Bobbert T, Ristow M, Rochlitz H, Weickert MO,Pfeiffer AF, Spranger J. Acetylsalicylic acid improves lipid-induced insulinresistance in healthy men. J Clin Endocrinol Metab. 2006 Mar;91(3):964-7. Epub2005 Dec 29. PubMed PMID: 16384847. See more on PubMed
  • Mojiminiyi OA, Abdella NA, Al Arouj M, Ben Nakhi A. Adiponectin, insulinresistance and clinical expression of the metabolic syndrome in patients withType 2 diabetes. Int J Obes (Lond). 2007 Feb;31(2):213-20. Epub 2006 Jun 6.PubMed PMID: 16755284. See more on PubMed
  • Moro C, Klimcakova E, Lolmède K, Berlan M, Lafontan M, Stich V, Bouloumié A,Galitzky J, Arner P, Langin D. Atrial natriuretic peptide inhibits the productionof adipokines and cytokines linked to inflammation and insulin resistance inhuman subcutaneous adipose tissue. Diabetologia. 2007 May;50(5):1038-47. Epub2007 Feb 23. PubMed PMID: 17318625. See more on PubMed
  • Novotny D, Vaverkova H, Karasek D, Lukes J, Slavik L, Malina P, Orsag J.Evaluation of total adiponectin, adipocyte fatty acid binding protein andfibroblast growth factor 21 levels in individuals with metabolic syndrome.Physiol Res. 2014;63(2):219-28. Epub 2014 Jan 8. PubMed PMID: 24397811. See more on PubMed
  • Oranskiy SP, Yeliseyeva LN, Tsanaeva AV, Zaytseva NV. Body composition andserum levels of adiponectin, vascular endothelial growth factor, andinterleukin-6 in patients with rheumatoid arthritis. Croat Med J. 2012Aug;53(4):350-6. PubMed PMID: 22911528; PubMed Central PMCID: PMC3429942. See more on PubMed
  • Otto C, Otto B, Frost RJ, Vogeser M, Pfeiffer AF, Spranger J, Parhofer KG.Short-term therapy with atorvastatin or fenofibrate does not affect plasmaghrelin, resistin or adiponectin levels in type 2 diabetic patients with mixedhyperlipoproteinaemia. Acta Diabetol. 2007 Jun;44(2):65-8. Epub 2007 May 27.PubMed PMID: 17530469. See more on PubMed
  • Otto C, Otto B, Göke B, Pfeiffer AF, Lehrke M, Vogeser M, Spranger J, ParhoferKG. Increase in adiponectin levels during pioglitazone therapy in relation toglucose control, insulin resistance as well as ghrelin and resistin levels. JEndocrinol Invest. 2006 Mar;29(3):231-6. PubMed PMID: 16682836. See more on PubMed
  • Ozmen HK, Erdemci B, Askin S, Sezen O. Carnitine and Adiponectin Levels inBreast Cancer after Radiotherapy. Open Med (Wars). 2017 Jun 16;12:189-194. doi:10.1515/med-2017-0028. eCollection 2017. PubMed PMID: 28730178; PubMed CentralPMCID: PMC5506391. See more on PubMed
  • Pilz S, Horejsi R, Möller R, Almer G, Scharnagl H, Stojakovic T, Dimitrova R, Weihrauch G, Borkenstein M, Maerz W, Schauenstein K, Mangge H. Earlyatherosclerosis in obese juveniles is associated with low serum levels ofadiponectin. J Clin Endocrinol Metab. 2005 Aug;90(8):4792-6. Epub 2005 May 31.PubMed PMID: 15928248. See more on PubMed
  • Pilz S, Maerz W, Weihrauch G, Sargsyan K, Almer G, Nauck M, Boehm BO,Winkelmann BR, Mangge H; LUdwigshafen RIsk and Cardiovascular Health (LURIC)Group. Adiponectin serum concentrations in men with coronary artery disease: the LUdwigshafen RIsk and Cardiovascular Health (LURIC) study. Clin Chim Acta. 2006Feb;364(1-2):251-5. Epub 2005 Aug 18. PubMed PMID: 16111669. See more on PubMed
  • Pilz S, Mangge H, Wellnitz B, Seelhorst U, Winkelmann BR, Tiran B, Boehm BO,März W. Adiponectin and mortality in patients undergoing coronary angiography. J Clin Endocrinol Metab. 2006 Nov;91(11):4277-86. Epub 2006 Aug 15. PubMed PMID:16912132. See more on PubMed
  • Polak J, Kovacova Z, Holst C, Verdich C, Astrup A, Blaak E, Patel K, OppertJM, Langin D, Martinez JA, Sørensen TI, Stich V. Total adiponectin andadiponectin multimeric complexes in relation to weight loss-induced improvements in insulin sensitivity in obese women: the NUGENOB study. Eur J Endocrinol. 2008 Apr;158(4):533-41. doi: 10.1530/EJE-07-0512. PubMed PMID: 18362301. See more on PubMed
  • Popova P, Vasilyeva L, Tkachuck A, Puzanov M, Golovkin A, Bolotko Y,Pustozerov E, Vasilyeva E, Li O, Zazerskaya I, Dmitrieva R, Kostareva A, Grineva E. A Randomised, Controlled Study of Different Glycaemic Targets duringGestational Diabetes Treatment: Effect on the Level of Adipokines in Cord Bloodand ANGPTL4 Expression in Human Umbilical Vein Endothelial Cells. Int JEndocrinol. 2018 May 14;2018:6481658. doi: 10.1155/2018/6481658. eCollection2018. PubMed PMID: 29861725; PubMed Central PMCID: PMC5976949. See more on PubMed
  • Risch L, Hoefle G, Saely C, Berchthold S, Weber M, Gouya G, Rein P, Langer P, Marte T, Aczel S, Drexel H. Evaluation of two fully automated novel enzyme-linkedimmunosorbent assays for the determination of human adiponectin in serum. ClinChim Acta. 2006 Nov;373(1-2):121-6. Epub 2006 May 17. PubMed PMID: 16797517. See more on PubMed
  • Risch L, Saely C, Hoefle G, Rein P, Langer P, Gouya G, Marte T, Aczel S,Drexel H. Relationship between glomerular filtration rate and the adipokinesadiponectin, resistin and leptin in coronary patients with predominantly normalor mildly impaired renal function. Clin Chim Acta. 2007 Feb;376(1-2):108-13. Epub2006 Jul 29. PubMed PMID: 16956602. See more on PubMed
  • Rubino E, Vacca A, Govone F, Gai A, Boschi S, Zucca M, De Martino P, GentileS, Pinessi L, Rainero I. Investigating the role of adipokines in chronicmigraine. Cephalalgia. 2017 Oct;37(11):1067-1073. doi: 10.1177/0333102416665871. Epub 2016 Aug 22. PubMed PMID: 27553954. See more on PubMed
  • Saely CH, Risch L, Hoefle G, Rein P, Muendlein A, Marte T, Aczel S, Langer P, Drexel H. Low serum adiponectin is independently associated with both themetabolic syndrome and angiographically determined coronary atherosclerosis. ClinChim Acta. 2007 Aug;383(1-2):97-102. Epub 2007 May 10. PubMed PMID: 17550784. See more on PubMed
  • Sahebkar A, Watts GF. Fibrate therapy and circulating adiponectinconcentrations: a systematic review and meta-analysis of randomizedplacebo-controlled trials. Atherosclerosis. 2013 Sep;230(1):110-20. doi:10.1016/j.atherosclerosis.2013.06.026. Epub 2013 Jul 12. Review. PubMed PMID:23958262. See more on PubMed
  • Senolt L, Pavelka K, Housa D, Haluzík M. Increased adiponectin is negativelylinked to the local inflammatory process in patients with rheumatoid arthritis.Cytokine. 2006 Sep;35(5-6):247-52. Epub 2006 Oct 31. PubMed PMID: 17079158. See more on PubMed
  • Serelis J, Kontogianni MD, Katsiougiannis S, Bletsa M, Tektonidou MG, SkopouliFN. Effect of anti-TNF treatment on body composition and serum adiponectin levelsof women with rheumatoid arthritis. Clin Rheumatol. 2008 Jun;27(6):795-7. doi:10.1007/s10067-008-0855-7. Epub 2008 Feb 28. PubMed PMID: 18305977. See more on PubMed
  • Shin MJ, Kang SM, Jang Y, Lee JH, Oh J, Chung JH, Chung N. Serum retinolbinding protein 4 levels are associated with serum adiponectin levels innon-diabetic, non-obese subjects with hypercholesterolemia. Clin Chim Acta. 2007 Mar;378(1-2):227-9. Epub 2006 Dec 15. PubMed PMID: 17250818. See more on PubMed
  • Shin MJ, Lee JH, Jang Y, Park E, Oh J, Chung JH, Chung N. Insulin resistance, adipokines, and oxidative stress in nondiabetic, hypercholesterolemic patients:leptin as an 8-epi-prostaglandin F2alpha determinant. Metabolism. 2006Jul;55(7):918-22. PubMed PMID: 16784964. See more on PubMed
  • Schnabel R, Messow CM, Lubos E, Espinola-Klein C, Rupprecht HJ, Bickel C,Sinning C, Tzikas S, Keller T, Genth-Zotz S, Lackner KJ, Münzel TF, BlankenbergS. Association of adiponectin with adverse outcome in coronary artery diseasepatients: results from the AtheroGene study. Eur Heart J. 2008 Mar;29(5):649-57. doi: 10.1093/eurheartj/ehn009. Epub 2008 Feb 9. PubMed PMID: 18263867. See more on PubMed
  • Spranger J, Verma S, Göhring I, Bobbert T, Seifert J, Sindler AL, Pfeiffer A, Hileman SM, Tschöp M, Banks WA. Adiponectin does not cross the blood-brainbarrier but modifies cytokine expression of brain endothelial cells. Diabetes.2006 Jan;55(1):141-7. PubMed PMID: 16380487. See more on PubMed
  • Stejskal D, Bartek J. Adiponectin in patients with various stages of coronary heart disease - comparison of its concentration in coronary arteries andperipheral venous circulation. Biomed Pap Med Fac Univ Palacky Olomouc CzechRepub. 2003 Dec;147(2):161-6. PubMed PMID: 15037897. See more on PubMed
  • Stejskal D, Proskova J, Solichova P. Adiponectin added into the plasma ofhealthy probands does not affect platelet aggregability. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2006 Jul;150(1):89-90. PubMed PMID: 16936907. See more on PubMed
  • Stejskal D, Růzicka V, Adamovská S, Juráková R, Prosková J, Jedelský L, BartekJ. Adiponectin concentrations as a criterion of metabolic control in persons withtype 2 diabetes mellitus? Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub.2003 Dec;147(2):167-72. PubMed PMID: 15037898. See more on PubMed
  • Stejskal D, Růzicka V, Fanfrdlová G, Kolár V, Bartek J. High adiponectin andTNF-alpha levels in moderate drinkers suffering from liver steatosis: comparison with non drinkers suffering from similar hepatopathy. Biomed Pap Med Fac UnivPalacky Olomouc Czech Repub. 2005 Jun;149(1):93-9. PubMed PMID: 16170395. See more on PubMed
  • Tsioufis C, Dimitriadis K, Chatzis D, Vasiliadou C, Tousoulis D, PapademetriouV, Toutouzas P, Stefanadis C, Kallikazaros I. Relation of microalbuminuria toadiponectin and augmented C-reactive protein levels in men with essentialhypertension. Am J Cardiol. 2005 Oct 1;96(7):946-51. PubMed PMID: 16188522. See more on PubMed
  • Tvarijonaviciute A, Jaillardon L, Cerón JJ, Siliart B. Effects of thyroxintherapy on different analytes related to obesity and inflammation in dogs withhypothyroidism. Vet J. 2013 Apr;196(1):71-5. doi: 10.1016/j.tvjl.2012.08.005.Epub 2012 Sep 6. PubMed PMID: 22959710. See more on PubMed
  • van Gemert WA, Monninkhof EM, May AM, Elias SG, van der Palen J, Veldhuis W,Stapper M, Stellato RK, Schuit JA, Peeters PH. Association between changes in fatdistribution and biomarkers for breast cancer. Endocr Relat Cancer. 2017Jun;24(6):297-305. doi: 10.1530/ERC-16-0490. Epub 2017 May 16. PubMed PMID:28512158. See more on PubMed
  • Vaverkova H, Karasek D, Novotny D, Jackuliakova D, Halenka M, Lukes J,Frohlich J. Positive association of adiponectin with soluble vascular celladhesion molecule sVCAM-1 levels in patients with vascular disease ordyslipidemia. Atherosclerosis. 2008 Apr;197(2):725-31. Epub 2007 Aug 21. PubMedPMID: 17714716. See more on PubMed
  • Vaverkova H, Karasek D, Novotny D, Kovarova D, Halenka M, Slavik L, FrohlichJ. Positive association of adiponectin with soluble thrombomodulin, vonWillebrand factor and soluble VCAM-1 in dyslipidemic subjects. Clin Biochem. 2013Jun;46(9):766-71. doi: 10.1016/j.clinbiochem.2013.02.014. Epub 2013 Mar 13.PubMed PMID: 23499586. See more on PubMed
  • Vitkova M, Klimcakova E, Kovacikova M, Valle C, Moro C, Polak J, Hanacek J,Capel F, Viguerie N, Richterova B, Bajzova M, Hejnova J, Stich V, Langin D.Plasma levels and adipose tissue messenger ribonucleic acid expression ofretinol-binding protein 4 are reduced during calorie restriction in obesesubjects but are not related to diet-induced changes in insulin sensitivity. JClin Endocrinol Metab. 2007 Jun;92(6):2330-5. Epub 2007 Apr 3. PubMed PMID:17405846. See more on PubMed
  • von Eynatten M, Hamann A, Twardella D, Nawroth PP, Brenner H, Rothenbacher D. Relationship of adiponectin with markers of systemic inflammation, atherogenicdyslipidemia, and heart failure in patients with coronary heart disease. ClinChem. 2006 May;52(5):853-9. Epub 2006 Mar 23. PubMed PMID: 16556684. See more on PubMed
  • Weickert MO, Möhlig M, Schöfl C, Arafat AM, Otto B, Viehoff H, Koebnick C,Kohl A, Spranger J, Pfeiffer AF. Cereal fiber improves whole-body insulinsensitivity in overweight and obese women. Diabetes Care. 2006 Apr;29(4):775-80. PubMed PMID: 16567814. See more on PubMed
Summary References (17)

References to Adiponectin

  • Lam KS, Xu A. Adiponectin: protection of the endothelium. Curr Diab Rep. 2005, 5, 254–259.
  • Ding X, Saxena NK, Lin S, Xu A, Srinivasan S, Anania FA. The roles of leptin and adiponectin: a novel paradigm in adipocytokine regulation of liver fibrosis and stellate cell biology. Am J Pathol. 2005, 166, 1655–1669.
  • Xu A, Chan KW, Hoo RL, Wang Y, Tan KC, Zhang J, Chen B, Lam MC, Tse C, Cooper GJ, Lam KS. Testosterone selectively reduces the high molecular weight form of adiponectin by inhibiting its secretion from adipocytes. J Biol Chem. 2005, 280, 18073–18080.
  • Wang Y, Lam KS, Xu JY, Lu G, Xu LY, Cooper GJ, Xu A. Adiponectin inhibits cell proliferation by interacting with several growth factors in an oligomerization-dependent manner. J Biol Chem. 2005, 280, 18341–18347.
  • Ouchi N, Kobayashi H, Kihara S, Kumada M, Sato K, Inoue T, Funahashi T, Walsh K. Adiponectin stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signaling in endothelial cells. J Biol Chem. 2004, 279, 1304–1309.
  • Ishikawa Y, Akasaka Y, Ishii T, Yoda-Murakami M, Choi-Miura NH, Tomita M, Ito K, Zhang L, Akishima Y, Ishihara M, Muramatsu M, Taniyama M. Changes in the distribution pattern of gelatinbinding protein of 28 kDa (adiponectin) in myocardial remodelling after ischaemic injury. Histopathology. 2003, 42, 43–52.
  • Diez JJ, Iglesias P. The role of the novel adipocyte-derived hormone adiponectin in human disease. Eur J Endocrinol. 2003, 148, 293–300.
  • Waki H, Yamauchi T, Kamon J, Ito Y, Uchida S, Kita S, Hara K, Hada Y, Vasseur F, Froguel P, Kimura S, Nagai R, Kadowaki T. Impaired multimerization of human adiponectin mutants associated with diabetes. Molecular structure and multimer formation of adiponectin. J Biol Chem. 2003, 278, 40352–40363.
  • Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, Sugiyama T, Miyagishi M, Hara K, Tsunoda M, Murakami K, Ohteki T, Uchida S, Takekawa S, Waki H, Tsuno NH, Shibata Y, Terauchi Y, Froguel P, Tobe K, Koyasu S, Taira K, Kitamura T, Shimizu T, Nagai R, Kadowaki T. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature. 2003, 423, 762–769.
  • Yamauchi T, Kamon J, Waki H, Imai Y, Shimozawa N, Hioki K, Uchida S, Ito Y, Takakuwa K, Matsui J, Takata M, Eto K, Terauchi Y, Komeda K, Tsunoda M, Murakami K, Ohnishi Y, Naitoh T, Yamamura K, Ueyama Y, Froguel P, Kimura S, Nagai R, Kadowaki T. Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis. J Biol Chem. 2003, 278, 2461–2468.
  • Daimon M, Oizumi T, Saitoh T, Kameda W, Hirata A, Yamaguchi H, Ohnuma H, Igarashi M, Tominaga M, Kato T. Decreased serum levels of adiponectin are a risk factor for the progression to type 2 diabetes in the Japanese Population: the Funagata study. Diabetes Care. 2003 Jul;26(7):2015–20.
  • Pajvani UB, Du X, Combs TP, Berg AH, Rajala MW, Schulthess T, Engel J, Brownlee M, Scherer PE. Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin. Implications for metabolic regulation and bioactivity. J Biol Chem. 2003, 278, 9073–9085.
  • Spranger J, Kroke A, Mohlig M, Bergmann MM, Ristow M, Boeing H, Pfeiffer AF. Adiponectin and protection against type 2 diabetes mellitus. Lancet. 2003, 361, 226–228.
  • Kondo H, Shimomura I, Matsukawa Y, Kumada M, Takahashi M, Matsuda M, Ouchi N, Kihara S, Kawamoto T, Sumitsuji S, Funahashi T, Matsuzawa Y. Association of adiponectin mutation with type 2 diabetes: a candidate gene for the insulin resistance syndrome. Diabetes. 2002, 51, 2325–2328.
  • Wang Y, Xu A, Knight C, Xu LY, Cooper GJ. Hydroxylation and glycosylation of the four conserved lysine residues in the collagenous domain of adiponectin. Potential role in the modulation of its insulin-sensitizing activity. J Biol Chem. 2002, 277, 19521–19529.
  • Tsao TS, Lodish HF, Fruebis J. ACRP30, a new hormone controlling fat and glucose metabolism. Eur J Pharmacol. 2002, 440, 213–21.
  • Das K, Lin Y, Widen E, Zhang
Related Products Docs