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You are here:   Home Products and Services Immunoassays Alpha-1-Antitrypsin in Stool Human ELISA
Distributed product

Alpha-1-Antitrypsin in Stool Human ELISA

  • Regulatory status:RUO
  • Type:Sandwich ELISA, HRP-labelled antibody
  • Other names:α-1-AT, A1AT, A1-AT, A1A, AAT, alpha1-proteinase inhibitor, A1PI, alpha1-antiproteinase, A1AP, SERPINA1, SERPIN A1, serpin family A member 1, PI, PI1, PRO2275, alpha1AT, nNIF, serum trypsin inhibitor, STI
  • Species:Human
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Cat. No. Size Price

IC6200 96 wells (1 kit)
PubMed Product Details
Technical Data

Cat # changed from RIC6200 to IC6200

Type

Sandwich ELISA, HRP-labelled antibody

Applications

Stool, Serum, Plasma-EDTA

Sample Requirements

100 µl/well

Shipping

At ambient temperature. Upon receipt, store the product at the temperature recommended below.

Storage/Expiration

Store the complete kit at 2–8°C. Under these conditions, the kit is stable until the expiration date (see label on the box).

Calibration Curve

Calibration Range

90-3,3 ng/ml

Limit of Detection

1.5 ng/ml

Intra-assay (Within-Run)

8,7%

Inter-assay (Run-to-Run)

11,9%

Spiking Recovery

80,3-105,2 %

Dilution Linearity

76,1-92,2 %

Note

The kits are CE-IVD certified and intended for professional use.

Summary

Features

  • European Union: for in vitro diagnostic use
  • Rest of the world: for research use only!

Research topic

Immune Response, Infection and Inflammation

Summary

Alpha-1-Antitrypsin is a 52 kD glycoprotein, which is produced by the liver, intestinal macrophages, monocytes and mucous membrane cells of the gut. It belongs to the group of acute phase proteins and is one of the most important proteinase inhibitor. Alpha-1-antitrypsin inhibits, beside others, the proteinases trypsin and the elastase of neutrophiles. A lack of α-1-AT leads to an enhanced proteolysis. Only a very small amount of alpha-1-antitrypsin is cleaved or resorbed in the gut. Therefore the measurement of α-1-AT in stool reflects the permeability of the gut during inflammatory processes.

Product References (13)

References

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  • Fahim SM, Das S, Sanin KI, Gazi MA, Mahfuz M, Islam MM, Ahmed T. Association of Fecal Markers of Environmental Enteric Dysfunction with Zinc and Iron Status among Children at First Two Years of Life in Bangladesh. Am J Trop Med Hyg. 2018 Aug;99(2):489-494. doi: 10.4269/ajtmh.17-0985. Epub 2018 Jun 7. PubMed PMID: 29893201. PubMed CentralPMCID: PMC6090336. See more on PubMed
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  • Arndt MB, Richardson BA, Mahfuz M, Ahmed T, Haque R, Gazi MA, John-Stewart GC, Denno DM, Scarlett JM, Walson JL. Plasma Fibroblast Growth Factor 21 Is Associated with Subsequent Growth in a Cohort of Underweight Children in Bangladesh. Curr Dev Nutr. 2019 Mar 30;3(5):nzz024. doi: 10.1093/cdn/nzz024. eCollection 2019 May. PubMed PMID: 31093598. PubMed CentralPMCID: PMC6511337. See more on PubMed
  • Fahim SM, Das S, Gazi MA, Mahfuz M, Ahmed T. Association of intestinal pathogens with faecal markers of environmental enteric dysfunction among slum-dwelling children in the first 2 years of life in Bangladesh. Trop Med Int Health. 2018 Nov;23(11):1242-1250. doi: 10.1111/tmi.13141. Epub 2018 Sep 10. PubMed PMID: 30133067. PubMed CentralPMCID: PMC6282798. See more on PubMed
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  • Kosek MN. Causal Pathways from Enteropathogens to Environmental Enteropathy: Findings from the MAL-ED Birth Cohort Study. EBioMedicine. 2017 Apr;18:109-117. doi: 10.1016/j.ebiom.2017.02.024. Epub 2017 Mar 8. PubMed PMID: 28396264. PubMed CentralPMCID: PMC5405169. See more on PubMed
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