Select country set
language
Menu Shopping cart 0,00 Search
Distributed product

Anti CP IgG

  • Regulatory status:RUO
  • Type:Capture ELISA, HRP-labelled antibody
  • Other names:Anti Citrullinated Peptides, Anti-Citrullinated Peptides
  • Species:Human
Please select your region to see available products and prices.
Cat. No. Size Price


New DKO149 96 wells (1 kit)
PubMed Product Details
Technical Data

Type

Capture ELISA, HRP-labelled antibody

Applications

Serum, Plasma

Sample Requirements

1 µl/well

Shipping

Shipped on ice packs. Upon receipt, store the product at the temperature recommended below.

Storage/Expiration

Store the complete kit at 2 – 8 °C. Under these conditions, all components are stable until the expiration date (see label on the box).

Calibration Range

5 - 80 AU/ml

Summary

Features

European Union: for in vitro diagnostic use

Rest of the world: for research use only!

The total assay time is less than 1.5 hours

Quantitative determination of IgG class antibodies directed against Citrullinated Peptides (CP) in human serum or plasma Cut-off value: 10 AU/ml
Assay format is 96 wells

RA: clinical specificity: 94% and clinical sensitivity: 76%
Quality Controls (positive and negative) and Standards are ready to use For routine analysis

Research topic

Autoimmunity

Summary

Reumathoid Arthritis (RA) is one of the most common autoimmune diseases (1-2% European population). The most significant clinical symptom is an inflammation of the synovial membranes which causes a painful swelling of the articulations and the ankylosis. In order to correctly diagnose RA it is necessary to exclude other forms of arthritis: in this diagnostic process, the laboratory plays an important role in the determination of Rheumatoid Factor (RF) antibodies of class IgM, detectable in 60-80% of the patients with RA. The RF antibodies are sensitive but not very specific markers. On the contrary, anti citrullinated peptides (CP) autoantibodies are a hallmark of RA and are used in diagnostic assays, through the use of citrullinated sequences (such as: filaggrin and filaggrin derived cyclized peptides, citrullinated recombinant vimentin, fibrin, viral citrullinated proteins) as antigens. DiaMetra Anti CP IgG assay is based on viral and human citrullinated peptidic sequences that are used as antigens; this combined use allows to detect different subgroups of anti CP antibodies in the same set of patients, leading to a better diagnostic investigation.

Related Products Docs