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Anti-human tissue transglutaminase sIgA/IgA ELISA

  • Regulatory status:RUO
  • Type:Sandwich ELISA, HRP-labelled antibody
  • Species:Human
Cat. No. Size Price

Discount IC6400 96 wells (1 kit) $635
PubMed Product Details
Technical Data


Sandwich ELISA, HRP-labelled antibody




Store the complete kit at 2–8°C. Under these conditions, the kit is stable until the expiration date (see label on the box).

Limit of Detection

2.9 mU/g

Spiking Recovery


Dilution Linearity

The linearity of the test ranges from 25 to 200 mU/g stool.



  • European Union: for in vitro diagnostic use
  • rest of the world: for research use only!
  • The kit is intended for the quantitative determination of anti-human tissue transglutaminase sIgA/IgA in stool.
  • Assay format is 96 wells
  • Components of the kit are provided ready to use or concentrated

Research topic

Diabetology - Autoimmunity


In the case of gluten intolerance, the body reacts hypersensitively to the gluten proteins (gliadin and glutenin) that are present in grain. 80-90% of patients have atypical or no symptoms and often do not know anything about their disease. In people with celiac disease, the intake of gluten leads to inflammation of the intestinal mucosa. The intestinal villi recede. Since the diseased intestinal mucosa can no longer absorb enough nutrients, a vitamin and mineral deficiency can occur. Hereditary factors (95% of patients have the HLA-DQ2 and HLA-DQ8 genes; up to 5% have the HLA-DR4 gene) play an important role in celiac disease, but the immune system and environmental factors also influence its development. Women get sick than men. According to the German Celiac Society, more recent screening tests show that the frequency of the disease is now between 1:100 and 1:200.
Antibodies against transglutaminase and/or gliadin can be detected in patients with gluten enteropathy. These antibodies can be detected regardless of whether the disease is manifest or silent or latent. In contrast to manifest gluten enteropathy, silent or latent forms do not show any atrophy of the villi of the small intestine, but pronounced intestinal or extraintestinal symptoms can still be present. The detection of anti-transglutaminase sIgA/IgA in the stool is suitable for screening and therapy monitoring. Elevated titers are not evidence of celiac disease (2). Celiac disease is detected by serum tests and a histological finding of villous atrophy.


  • Food intolerance
  • Monitoring of an elimination diet The ImmuChrom complete anti-human tissue transglutaminase sIgA / IgA kit allows an easy, rapid and precise quantitative determination of the antibodies in biological samples.
  • The kit includes all reagents ready to use for preparation of the samples.
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