Aquaporin-4 Autoantibody Human ELISA

Cat. No.	Size	Price
RAQP4/96/2R	96 wells (1 kit)

Technical Data

Type

Sandwich ELISA, Biotin-labelled antibody

Applications

Serum

Sample Requirements

50 μl/well

Shipping

At ambient temperature. Upon receipt, store the product at the temperature recommended below.

Storage/Expiration

Store the complete kit at 2–8°C. Under these conditions, the kit is stable until the expiration date (see label on the box).

Calibration Curve

Calibration Range

80-1,5 u/ml

Limit of Detection

0.17 u/mL

Intra-assay (Within-Run)

7,7 %

Inter-assay (Run-to-Run)

10,5 %

Product References (5)

References

Weinshenker BG, Wingerchuk DM, Vukusic S, Linbo L, Pittock SJ, Lucchinetti CF,Lennon VA. Neuromyelitis optica IgG predicts relapse after longitudinallyextensive transverse myelitis. Ann Neurol. 2006 Mar;59(3):566-9. PubMed PMID:16453327. See more on PubMed
Isobe N, Yonekawa T, Matsushita T, Kawano Y, Masaki K, Yoshimura S, Fichna J, Chen S, Furmaniak J, Smith BR, Kira J. Quantitative assays for anti-aquaporin-4antibody with subclass analysis in neuromyelitis optica. Mult Scler. 2012Nov;18(11):1541-51. doi: 10.1177/1352458512443917. Epub 2012 Apr 23. PubMed PMID:22526930. See more on PubMed
Jarius S, Franciotta D, Paul F, Bergamaschi R, Rommer PS, Ruprecht K,Ringelstein M, Aktas O, Kristoferitsch W, Wildemann B. Testing for antibodies to human aquaporin-4 by ELISA: sensitivity, specificity, and direct comparison with immunohistochemistry. J Neurol Sci. 2012 Sep 15;320(1-2):32-7. doi:10.1016/j.jns.2012.06.002. Epub 2012 Jun 16. PubMed PMID: 22705047. See more on PubMed
Lennon VA, Wingerchuk DM, Kryzer TJ, Pittock SJ, Lucchinetti CF, Fujihara K,Nakashima I, Weinshenker BG. A serum autoantibody marker of neuromyelitis optica:distinction from multiple sclerosis. Lancet. 2004 Dec 11-17;364(9451):2106-12.PubMed PMID: 15589308. See more on PubMed
Lennon VA, Kryzer TJ, Pittock SJ, Verkman AS, Hinson SR. IgG marker ofoptic-spinal multiple sclerosis binds to the aquaporin-4 water channel. J ExpMed. 2005 Aug 15;202(4):473-7. Epub 2005 Aug 8. PubMed PMID: 16087714; PubMedCentral PMCID: PMC2212860. See more on PubMed

Summary References (5)

References to Aquaporin-4 Autoantibody

Isobe N, Yonekawa T, Matsushita T, Kawano Y, Masaki K, Yoshimura S, Fichna J, Chen S, Furmaniak J, Smith BR, Kira J. Quantitative assays for anti-aquaporin-4 antibody with subclass analysis in neuromyelitis optica. Mult Scler. 2012 Nov;18 (11):1541-51
Jarius S, Franciotta D, Paul F, Bergamaschi R, Rommer PS, Ruprecht K, Ringelstein M, Aktas O, Kristoferitsch W, Wildemann B. Testing for antibodies to human aquaporin-4 by ELISA: sensitivity, specificity, and direct comparison with immunohistochemistry. J Neurol Sci. 2012 Sep 15;320 (1-2):32-7
Lennon VA, Kryzer TJ, Pittock SJ, Verkman AS, Hinson SR. IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel. J Exp Med. 2005 Aug 15;202 (4):473-7
Lennon VA, Wingerchuk DM, Kryzer TJ, Pittock SJ, Lucchinetti CF, Fujihara K, Nakashima I, Weinshenker BG. A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis. Lancet. 2004 Dec 11-17;364 (9451):2106-12
Weinshenker BG, Wingerchuk DM, Vukusic S, Linbo L, Pittock SJ, Lucchinetti CF, Lennon VA. Neuromyelitis optica IgG predicts relapse after longitudinally extensive transverse myelitis. Ann Neurol. 2006 Mar;59 (3):566-9

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