Type
Sandwich ELISA, Biotin-labelled antibody
Description
The CardiNor Secretoneurin ELISA Assay is an in vitro diagnostic test designed to detect and quantify the level of human secretoneurin (SN) in serum and plasma. It is indicated to be used in conjunction with clinical evaluation as an aid in
assessing the prognosis of patients diagnosed with heart failure.
The test is intended to be used by professionals.
Applications
Serum, Plasma-EDTA, Plasma-Heparin
Sample Requirements
10 µl/well
Shipping
On blue ice packs. Upon receipt, store the product at the temperature recommended below.
Storage/Expiration
Store the complete kit at 2–8°C. Under these conditions, the kit is stable until the expiration date (see label on the box).
Calibration Range
10 - 250 pmol/l
Limit of Detection
5.1 pmol/l
Note
The kits are CE-IVD certified and intended for professional use.
Features
- European Union: for in vitro diagnostic use
- rest of the world: RUO
- the kit measures secretoneurin in human serum and EDTA/ heparin plasma
- Measuring range: 10 - 250 pmol/L
- limit of detection 5.1 pmol/L
Research topic
Cardiovascular disease, Sepsis
Summary
Secretoneurin is a 33-amino acid neuropeptide produced by the endoproteolytic cleavage of chromogranin/secretogranin proteins. Secretoneurin is produced by neuroendocrine- and heart muscle cells and is detectable in the blood stream. Circulating secretoneurin concentrations are increased in patients with acute heart failure in proportion to disease
severity in patients with arrhythmia-induced cardiac arrest2, after coronary artery bypass grafting3, and in critically ill patients with severe infections1
. Secretoneurin is a strong predictor of mortality in patients with acute heart failure, in acute respiratory failure patients with CVD, in patients with severe sepsis, and in patients with acute coronary syndrom.
