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Elastin

Elastin is a key extracellular matrix protein that is critical to the elasticity and resilience of many vertebrate tissues including large arteries, lung, ligament, tendon, skin, and elastic cartilage. Tropoelastin associates with multiple tropoelastin molecules during the major phase of elastogenesis through coacervation, where this process is directed by the precise patterning of mostly alternating hydrophobic and hydrophilic sequences that dictate intermolecular alignment. Massively crosslinked arrays of tropoelastin (typically in association with microfibrils) contribute to tissue structural integrity and biomechanics through persistent flexibility, allowing for repeated stretch and relaxation cycles that critically depend on hydrated environments. Elastin sequences interact with multiple proteins found in or colocalized with microfibrils, and bind to elastogenic cell surface receptors. Knowledge of the major stages in elastin assembly has facilitated the construction of in vitro models of elastogenesis, leading to the identification of precise molecular regions that are critical to elastin-based protein interactions.

4 results found in Extracellular Matrix Assays

Extracellular Matrix Assays
Product Size Price
Fastin™ Dye Reagent

Type: Colorimetric assay

F2300 3x 110 ml
 
Fastin™ Elastin Assay (Large Economy Kit)

Type: Colorimetric assay

F4000 440 assays (1 kit)
 
Fastin™ Elastin Assay (Standard Kit Size)

Type: Colorimetric assay

F2000 110 assays (1 kit)
 
Fastin™ Elastin Reference Standard (1 mg/ml)

Type: Colorimetric assay

F2010 3x 5 ml