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ENDONEXT™ EndoZyme® II – Recombinant Factor C (rFC) Endotoxin Detection Assay

  • Regulatory status:RUO
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Cat. No. Size Price

890030 192 Tests
Product Details
Technical Data


The ENDONEXT™ EndoZyme® II assay is the enhanced second generation of EndoZyme®, based on recombinant Factor C (rFC), the synthetic analogue to the native endotoxin-specific principal receptor in the Limulus Amebocyte Lysate (LAL) cascade. Instead of being based on an animal source, EndoZyme® II is a sustainable alternative method in line with regulatory requirements. EndoZyme® II is particularly suited for end-product testing and in-process control of water and raw materials, as well as medical device testing.


At ambient temperature. Upon receipt, store the product at the temperature recommended below.


Unopened kits are stable at 2–8°C until the expiry date printed on the label.

Calibration Range

0.005 – 50 EU/ml

Limit of Detection

0.005 EU/mL



EndoZyme® II Features:

  • Horseshoe Crab-free method relying on sustainable resources
  • State-of-the-art sensitivity (0.005 EU/ml) and assay range
  • Endotoxin-specific, no false-positive results from β-Glucans
  • Excellent lot-to-lot reproducibility
  • Stable liquid reagents enabling flexibility in use
  • Follows BET methodology and validated according to the same criteria as conventional methods
  • Accepted by the FDA and included in the European Pharmacopoeia Chapter 5.1.10 since 2016.


ENDONEXT™ EndoZyme® II is a fluorescence end-point assay intended for quantitative determination of endotoxin (chemically lipopolysaccharide, LPS) in pharmaceutical end-products, in-process control and research samples, and medical device testing.