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Fibroblast Growth Factor 21 Mouse/Rat ELISA

  • Regulatory status:RUO
  • Type:Sandwich ELISA, Biotin-labelled antibody
  • Other names:FGF-21, UNQ3115/PRO10196
  • Species:Mouse, Rat
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Cat. No. Size Price


RD291108200R 96 wells (1 kit)
PubMed Product Details
Technical Data

Type

Sandwich ELISA, Biotin-labelled antibody

Applications

Serum

Sample Requirements

mouse samples: 7 µl/well
rat samples: 50 µl/well

Shipping

At ambient temperature. Upon receipt, store the product at the temperature recommended below.

Storage/Expiration

Store the complete kit at 2–8°C. Under these conditions, the kit is stable until the expiration date (see label on the box).

Calibration Curve

Calibration Range

40–2560 pg/ml

Limit of Detection

18.4 pg/ml

Intra-assay (Within-Run)

mouse samples CV = 8.4%
rat samples CV = 8.5%

Inter-assay (Run-to-Run)

mouse samples CV = 8.7%
rat samples CV = 6%

Spiking Recovery

mouse samples 98.9%
rat samples 104.5

Dilutation Linearity

mouse samples 99.8%
rat samples 103.7%

Crossreactivity

  • bovine Weak reactivity (recom. dilution 1:3)
  • cat Yes (recommended dilution 1:3)
  • dog Non-detectable
  • horse Non-detectable
  • goat Yes (recommended dilution 1:6)
  • hamster Yes (recommended dilution 1:12)
  • human Non-detectable
  • monkey Non-detectable
  • rabbit Non-detectable
  • chicken Not tested
  • mouse Yes
  • rat Yes
  • sheep Yes (recommended dilution 1:3)
  • pig Yes (recommended dilution 1:3)
Summary

Research topic

Diabetology - Other Relevant Products, Energy metabolism and body weight regulation, Animal studies

Summary

The FGFs are a family of more than 20 small (~17–26 kDa) secreted peptides. The initial characterization of these proteins focused on their ability to stimulate fibroblast proliferation. This mitogenic activity was mediated through FGF receptors (FGFRs) 1, 2, or 3. A fourth closely related tyrosine kinase receptor (FGFR4) was able to bind the FGFs but did not lead to a mitogenic response.

FGFs modulate cellular activity via at least 5 distinct subfamilies of high-affinity FGF receptors (FGFRs): FGFR-1, –2, –3, and –4, all with intrinsic tyrosine kinase activity and, except for FGFR-4, multiple splice isoforms, and FGFR-5, which lacks an intracellular kinase domain. There is growing evidence that FGFRs can be important for regulation of glucose and lipid homeostasis. The overexpression of a dominant negative form of FGFR-1 in β cells leads to diabetes in mice, which thus implies that proper FGF signaling is required for normal β cell function and glycemia maintenance. FGFR-2 appears to be a key molecule during pancreatic development. Moreover, FGFR-4 has been implicated in cholesterol metabolism and bile acid synthesis.

FGF-19, has been shown to cause resistance to diet-induced obesity and insulin desensitization and to improve insulin, glucose, and lipid profiles in diabetic rodents. Since these effects, at least in part, are mediated through the observed changes in metabolic rates, FGF-19 can be considered as a regulator of energy expenditure.

FGF-21 is preferentially expressed in liver, but an exact knowledge of FGF-21 bioactivity and its mode of action have been lacking to date. FGF-21 is a potent activator of glucose uptake on adipocytes, protects animals from diet-induced obesity when overexpressed in transgenic mice, and lowers blood glucose and triglyceride levels when therapeutically administered to diabetic rodents.

Product References (45)

References

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Summary References (16)

References to Fibroblast Growth Factor 21

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