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Glucagon-Like Peptide-2 Rat ELISA

  • Regulatory status:RUO
  • Type:Competitive ELISA, Immobilized antibody
  • Other names:GLP-2
  • Species:Rat
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Cat. No. Size Price


RSCYK140R 96 wells (1 kit)
PubMed Product Details
Technical Data

Type

Competitive ELISA, Immobilized antibody

Applications

Serum, Plasma-EDTA, Plasma-Heparin, Plasma-Citrate

Sample Requirements

25 µl/well

Shipping

At ambient temperature. Upon receipt, store the product at the temperature recommended below.

Storage/Expiration

Store the complete kit at 2–8°C. Under these conditions, the kit is stable until the expiration date (see label on the box).

Calibration Curve

Calibration Range

0.137–100 ng/ml

Intra-assay (Within-Run)

Plasma - CV (%) 3.1 - 7.2 Serum - CV (%) 3.5 - 8.9

Inter-assay (Run-to-Run)

Plasma - CV (%) 6.7 - 11.5 Serum - CV (%) 7.6 - 13.0

Spiking Recovery

Rat serum 111,2 % Rat plasma 108,7 %

Summary

Research topic

Diabetology - Other Relevant Products, Animal studies

Summary

The proglucagon gene is expressed in both pancreatic A cell and intestinal L cell. Tissue-specific posttranslational processing of proglucagon by the prohormone convertase produced the different proglucagon derived peptides (PGDPs) in both pancreas and intestine. The most notable pancreatic PGDP is glucagon, whereas the L cell produces several structurally related peptides, including glucagon-like peptide 1 (GLP-1) and GLP-2, as well as glicentin and oxyntomodulin, which contain glucagon sequence in their molecules. Among PGDPs, GLP-2 has recently been found to show intestinal epithelial proliferation.

Product References (3)

References

  • Drucker DJ, Erlich P, Asa SL, Brubaker PL. Induction of intestinal epithelial proliferation by glucagon-like peptide 2. Proc Natl Acad Sci U S A. 1996 Jul23;93(15):7911-6. PubMed PMID: 8755576; PubMed Central PMCID: PMC38848. See more on PubMed
  • Mojsov S, Heinrich G, Wilson IB, Ravazzola M, Orci L, Habener JF.Preproglucagon gene expression in pancreas and intestine diversifies at the levelof post-translational processing. J Biol Chem. 1986 Sep 5;261(25):11880-9. PubMedPMID: 3528148. See more on PubMed
  • Philippe J. Structure and pancreatic expression of the insulin and glucagongenes. Endocr Rev. 1991 Aug;12(3):252-71. Review. PubMed PMID: 1935821. See more on PubMed
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