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Homoarginine ELISA

  • Regulatory status:RUO
  • Type:Competitive ELISA
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Cat. No. Size Price


REA205/96R 96 wells (1 kit)
PubMed Product Details
Technical Data

Type

Competitive ELISA

Applications

Serum, Plasma, Cell culture supernatant

Sample Requirements

20 µl/well

Shipping

At ambient temperature. Upon receipt, store the product at the temperature recommended below.

Storage/Expiration

2–8°C

Calibration Range

7 - 0,3 µmol/l 1318 - 56 ng/ml

Limit of Detection

0.05 µmol/l

Intra-assay (Within-Run)

3,3 - 6,2 %

Spiking Recovery

95 - 103 %

Dilutation Linearity

99 - 103 %

Summary

Research topic

Cardiovascular disease

Summary

Homoarginine is a non-essential cationic amino acid, which is formed from lysine. In vitro and in vivo, homoarginine shows characteristics similar to arginine. Epidemiological investigations in two large independent cohorts, namely the German diabetes dialysis (4D) – study and the Ludwigshafen Risk and Cardiovascular Health (LURIC) – study have identified homoarginine as useful predictor of cardiovascular events and mortality. Beyond that homoarginine concentrations are directly correlated with kidney function and are significantly associated with the progression of chronic kidney disease (CKD). Low homoarginine concentrations might be an early indicator of kidney failure and a potential target for the prevention of disease progression which needs further investigations. Furthermore homoarginine could be a useful marker for the monitoring of hemodialysis patients.

References to Product

References

  • A. Meinitzer, Ch Drechsler. A. Tomaschitz, S. Pilz, V. Krane, Ch. Wanner, W. März Homoarginin, ein neuer kardiovaskulärer Risikomarker bei Dialysepatienten J. Lab. Med. 2011, 35 (3): 153 -159, copy 2011 by Walter de Gruyter, Berlin, Boston
  • A. Jazwinska-Kozuba, J. Martens-Lobenhoffer, O. Kruszelnicka, J. Rycaj, B. Chyrchel, A. Surdacki, S. M. Bode-Böger Opposite Associations of Plasma Homoarginine and Ornithine with Arginine in Healthy Children and Adolescents Int. J. Mol. Sci. 2013, 14, 21819-21832
  • A.A. Khalil, D. Tsikas, R. Akolekar, J. Jordan, K.H. Nicolaides Asymmetric dimethylarginine, arginine and homoarginine at 11-13 weeks´ gestation and preeclampsia: a case control study. J. of Human Hypertension January 2013 27; 38-43
  • Ch. Drechsel, B. Kolleritz. A, Meinitzer, W. März, E. Ritz, P. König, U. Neyer, S. Pilz, Ch. Wanner, F. Kronenberg Homoarginine and Progression of Chronic Kidney Disease: Results from the Mild to Moderate Kidney Disease Study May 2013; Plos One, 10, 1371
  • Choe CU, Atzler D, Wild PS, Carter AM, Böger RH, Ojeda F, Simova O, Stockebrand M, Lackner K, Nabuurs C, Marescau B, Streichert T, Müller C, Lüneburg N, De Deyn PP, Benndorf RA, Baldus S, Gerloff C, Blankenberg S, Heerschap A, Grant PJ, Magnus T, Zeller T, Isbrandt D, Schwedhelm E Homoarginine levels are regulated by L-arginine: glycine amidinotransferase and affect stroke outcome; results from human and murine studies Circulation, 2013 Sep 24, 128 (13) 1451-1461
  • Pietro Ravani, Renke Maas, Fabio Malberti, Paola Pecchini, Maren Mieth, Robert Quinn, Giovanni Tripepi, Francesca Mallamaci, Carmine Zoccali Homoarginine and Mortality in Pre-Dialysis Chronic Kidney Disease (CKD) Patients Plos One; September 2013, Volume 8, Issue 9: 1-6
  • van der Zwan, L., Davids, M., Scheffer, P.; et al. L-Homoarginine and L-arginine are antagonistically related to blood pressure in an elderly population: the Hoorn study Journal of Hypertension 2013: 31:1114–112
  • W. März A. Meinitzer, Ch. Drechsler, S. Pilz, V. Krane, M.E. Kleber, J. Fischer, B.R. Winkelmann, B.O. Böhm, E. Ritz, Ch. Wanner. Homoarginine, Cardiovascular Risk and Mortality Circulation 2010, 122: 967-975
References to Summary

References to Homoarginine

  • Choe CU, Atzler D, Wild PS, Carter AM, Boger RH, Ojeda F, Simova O, Stockebrand M, Lackner K, Nabuurs C, Marescau B, Streichert T, Muller C, Luneburg N, De Deyn PP, Benndorf RA, Baldus S, Gerloff C, Blankenberg S, Heerschap A, Grant PJ, Magnus T, Zeller T, Isbrandt D, Schwedhelm E. Homoarginine levels are regulated by L-arginine:glycine amidinotransferase and affect stroke outcome: results from human and murine studies. Circulation. 2013 Sep 24;128 (13):1451-61
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