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  • Regulatory status:RUO
  • Type:Sandwich ELISA, HRP-labelled antibody
  • Other names:C-Reactive Protein
  • Species:Human
Cat. No. Size Price

740001 96 wells (1 kit)
PubMed Product Details
Technical Data


Sandwich ELISA, HRP-labelled antibody


Enzyme Immunoassay for the Quantitative Determination of C-Reactive Protein in Human Serum and Plasma.


Serum, Plasma

Sample Requirements

10 µl/well


On blue ice packs. Upon receipt, store the product at the temperature recommended below.


Store the complete kit at 2–8°C. Under these conditions, the kit is stable until the expiration date (see label on the box).

Calibration Range

0–100 μg/ml

Limit of Detection

0.225 μg/ml


The kits are CE-IVD certified and intended for professional use.

More about CRP (C-Reactive Protein) on BioVendor Scientific Blog



  • European Union: for in vitro diagnostic use
  • rest of the world: RUO
  • the kit measures in human serum and plasma samples
  • calibration range 0-100 μg/ml
  • limit of detection 0.225 μg/ml

Research topic

Immune Response, Infection and Inflammation, Sepsis


C-Reactive Protein (CRP) is an acute-phase protein, produced exclusively in the liver. Interleukin-6 is the mediator for the synthesis by the hepatocytes of CRP, a pentamer of approximately 120.000 Daltons. CRP is present in the serum of normal persons at concentrations ranging up to 5 mg/l. The protein is produced by the foetus and the neonate and it does not pass the placental barrier, as such it can be used for the early detection of neonatal sepsis. Because febrile phenomena, leukocyte count and erythrocyte sedimentation rate (ESR) are often misleading, investigators and clinicians now prefer a quantitative CRP determination as a marker for acute inflammation and tissue necrosis. Within 6 hours of an acute inflammatory challenge the CRP level starts to rise. Serum concentration of CRP increases significantly in cases of both infectious and non-infectious inflammation, of tissue damage and necrosis and in the presence of malignant tumours. CRP is present in the active stages of inflammatory disorders like rheumatoid arthritis, ankylosing spondylitis, Reiter's syndrome, psoriatic arthropathy, systemic lupus erythematosus, polyarteritis, ulcerative colitis and Crohn's disease. Injuries causing tissue breakdown and necrosis are associated with increases in serum CRP which are seen in thermal burns, major surgery and myocardial infarction. Widespread malignant disease with carcinoma of the lung, stomach, colon, breast, prostate and pancreas, Hodgkin's disease, non-Hodgkin's lymphoma and lymphosarcoma will give rise to high levels of CRP resulting from tissue damage by invading tumour cells. CRP, therefore may be used to monitor malignancy. The CRP-level increases dramatically following microbial infections, and this maybe particularly helpful for the diagnosis and monitoring of bacterial septicemia in neonates and other immunocompromised patients at risk. In children, CRP is useful for differential diagnosis of bacterial and viral meningitis. Because the biological half-life of this protein is only 24 hours, CRP accurately parallels the activity of the inflammation process and the CRP concentration decreases much faster than ESR or any other acute phase parameter, which is particularly useful in monitoring appropriate treatment of bacterial diseases with antibiotics. C-Reactive Protein measurements during the early and late post-transplant period of bone marrow and organ transplantations is particularly useful in the management of interfering infections in these immunosuppressed patients.

Product References (2)


  • Mendoza E, Duque X, Hernández Franco JI, Reyes Maldonado E, Morán S, Martínez G, Salinas Rodríguez A, Martínez H. Association between Active H. pylori Infection and Iron Deficiency Assessed by Serum Hepcidin Levels in School-Age Children. Nutrients. 2019 Sep 7;11(9):2141. doi: 10.3390/nu11092141. PubMed PMID: 31500264. PubMed CentralPMCID: PMC6769883. See more on PubMed
  • Yen YT, Yang HR, Lo HC, Hsieh YC, Tsai SC, Hong CW, Hsieh CH. Enhancing autophagy with activated protein C and rapamycin protects against sepsis-induced acute lung injury. Surgery. 2013 May;153(5):689-98. doi: 10.1016/j.surg.2012.11.021. Epub 2013 Feb 19. PubMed PMID: 23434181. See more on PubMed
Summary References (3)

References to CRP

  • Gewurz H, Mold C, Siegel J, Fiedel B. C-reactive protein and the acute phaseresponse. Adv Intern Med. 1982;27:345-72. Review. PubMed PMID: 7041546. See more on PubMed
  • Johnson HL, Chiou CC, Cho CT. Applications of acute phase reactants ininfectious diseases. J Microbiol Immunol Infect. 1999 Jun;32(2):73-82. Review.PubMed PMID: 11561579. See more on PubMed
  • Powell LJ. C-reactive protein--a review. Am J Med Technol. 1979Feb;45(2):138-42. Review. PubMed PMID: 106726. See more on PubMed
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