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You are here:   Home Products and Services Immunoassays Human GDF-15 ELISA
Manufactured by BioVendor

Human GDF-15 ELISA

  • Regulatory status:RUO
  • Type:Sandwich ELISA
  • Other names:Growth differentiation factor 15, MIC-1, Macrophage Inhibitory Cytokine 1, Placental TGFβ, Prostate Differentiation Factor (PDF), PLAB, NRG-1
  • Species:Human
Cat. No. Size Price

New 31980 96 wells (1 kit)
PubMed Product Details
Technical Data

Type

Sandwich ELISA

Applications

Serum, Plasma, Cell culture supernatant

Sample Requirements

100µL (after dilution)

Storage/Expiration

2–8°C

Calibration Range

7.8-500 pg/mL

Limit of Detection

7.8 pg/mL

Intra-assay (Within-Run)

<10%

Inter-assay (Run-to-Run)

<10%

Summary

Features

  • Research Use Only.
  • This kit measures GDF-15 in human serum, plasma, and cell culture supernatant.
  • Assay format is 96 wells.
  • Components of the kit are provided ready-to-use, lyophilized, or concentrated.

Research topic

Cardiovascular disease, Cytokines and chemokines and related molecules, Oncology, Reproduction

Summary

Growth differentiation factor 15 (GDF-15) is a member of the TGFβ superfamily whose expression is increased in response to cellular stress and disease as well as by metformin. Identified as a new heart-derived endocrine hormone that regulates body growth, GDF-15 has a local cardioprotective role, presumably due to its autocrine/paracrine properties: antioxidative, anti-inflammatory, antiapoptotic. GDF-15 expression is highly induced in cardiomyocytes after ischemia/reperfusion and in the heart within hours after myocardial infarction (MI). GDF-15 may be a predictive biomarker of adverse cardiac events. Available evidence also suggests that a substantial amount of GDF-15 is secreted in various human cancers, such as ovarian cancer, prostate cancer, and breast cancer, among others.

Product References (9)

References

  • Xiao F, Jiang Y, Wang X, Jiang W, Wang L, Zhuang X, Zheng C, Ni Y, Chen L. NETosis may play a role in the pathogenesis of Hashimoto's thyroiditis. Int J Clin Exp Pathol. 2018 Feb 1;11(2):537-547. eCollection 2018. PubMed PMID: 31938139. PubMed CentralPMCID: PMC6958043. See more on PubMed
  • Wang Y, Xiao Y, Zhong L, Ye D, Zhang J, Tu Y, Bornstein SR, Zhou Z, Lam KS, Xu A. Increased neutrophil elastase and proteinase 3 and augmented NETosis are closely associated with β-cell autoimmunity in patients with type 1 diabetes. Diabetes. 2014 Dec;63(12):4239-48. doi: 10.2337/db14-0480. Epub 2014 Aug 4. PubMed PMID: 25092677. See more on PubMed
  • Nauseef WM, Borregaard N. Neutrophils at work. Nat Immunol. 2014 Jul;15(7):602-11. doi: 10.1038/ni.2921. PubMed PMID: 24940954. See more on PubMed
  • Mihara K, Ramachandran R, Renaux B, Saifeddine M, Hollenberg MD. Neutrophil elastase and proteinase-3 trigger G protein-biased signaling through proteinase-activated receptor-1 (PAR1). J Biol Chem. 2013 Nov 15;288(46):32979-90. doi: 10.1074/jbc.M113.483123. Epub 2013 Sep 19. PubMed PMID: 24052258. PubMed CentralPMCID: PMC3829148. See more on PubMed
  • Ng LL, Khan SQ, Narayan H, Quinn P, Squire IB, Davies JE. Proteinase 3 and prognosis of patients with acute myocardial infarction. Clin Sci (Lond). 2011 Mar;120(6):231-8. doi: 10.1042/CS20100366. PubMed PMID: 20942801. PubMed CentralPMCID: PMC2999885. See more on PubMed
  • Korkmaz B, Moreau T, Gauthier F. Neutrophil elastase, proteinase 3 and cathepsin G: physicochemical properties, activity and physiopathological functions. Biochimie. 2008 Feb;90(2):227-42. doi: 10.1016/j.biochi.2007.10.009. Epub 2007 Oct 25. PubMed PMID: 18021746. See more on PubMed
  • Pham CT. Neutrophil serine proteases: specific regulators of inflammation. Nat Rev Immunol. 2006 Jul;6(7):541-50. doi: 10.1038/nri1841. PubMed PMID: 16799473. See more on PubMed
  • Wiedow O, Meyer-Hoffert U. Neutrophil serine proteases: potential key regulators of cell signalling during inflammation. J Intern Med. 2005 Apr;257(4):319-28. doi: 10.1111/j.1365-2796.2005.01476.x. PubMed PMID: 15788001. See more on PubMed
  • van der Geld YM, Limburg PC, Kallenberg CG. Proteinase 3, Wegener's autoantigen: from gene to antigen. J Leukoc Biol. 2001 Feb;69(2):177-90. PubMed PMID: 11272267. See more on PubMed
Summary References (15)

References to GDF-15/MIC-1

  • Ago T, Sadoshima J. GDF15, a cardioprotective TGF-beta superfamily protein. Circ Res. 2006 Feb 17;98 (3):294-7
  • Bootcov MR, Bauskin AR, Valenzuela SM, Moore AG, Bansal M, He XY, Zhang HP, Donnellan M, Mahler S, Pryor K, Walsh BJ, Nicholson RC, Fairlie WD, Por SB, Robbins JM, Breit SN. MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-beta superfamily. Proc Natl Acad Sci U S A. 1997 Oct 14;94 (21):11514-9
  • Brown DA, Moore J, Johnen H, Smeets TJ, Bauskin AR, Kuffner T, Weedon H, Milliken ST, Tak PP, Smith MD, Breit SN. Serum macrophage inhibitory cytokine 1 in rheumatoid arthritis: a potential marker of erosive joint destruction. Arthritis Rheum. 2007 Mar;56 (3):753-64
  • Brown DA, Ward RL, Buckhaults P, Liu T, Romans KE, Hawkins NJ, Bauskin AR, Kinzler KW, Vogelstein B, Breit SN. MIC-1 serum level and genotype: associations with progress and prognosis of colorectal carcinoma. Clin Cancer Res. 2003 Jul;9 (7):2642-50
  • Eggers KM, Kempf T, Allhoff T, Lindahl B, Wallentin L, Wollert KC. Growth-differentiation factor-15 for early risk stratification in patients with acute chest pain. Eur Heart J. 2008 Oct;29 (19):2327-35
  • Huang CY, Beer TM, Higano CS, True LD, Vessella R, Lange PH, Garzotto M, Nelson PS. Molecular alterations in prostate carcinomas that associate with in vivo exposure to chemotherapy: identification of a cytoprotective mechanism involving growth differentiation factor 15. Clin Cancer Res. 2007 Oct 1;13 (19):5825-33
  • Keelan JA, Wang K, Chaiworapongsa T, Romero R, Mitchell MD, Sato TA, Brown DA, Fairlie WD, Breit SN. Macrophage inhibitory cytokine 1 in fetal membranes and amniotic fluid from pregnancies with and without preterm labour and premature rupture of membranes. Mol Hum Reprod. 2003 Sep;9 (9):535-40
  • Kempf T, Bjorklund E, Olofsson S, Lindahl B, Allhoff T, Peter T, Tongers J, Wollert KC, Wallentin L. Growth-differentiation factor-15 improves risk stratification in ST-segment elevation myocardial infarction. Eur Heart J. 2007 Dec;28 (23):2858-65
  • Kempf T, Eden M, Strelau J, Naguib M, Willenbockel C, Tongers J, Heineke J, Kotlarz D, Xu J, Molkentin JD, Niessen HW, Drexler H, Wollert KC. The transforming growth factor-beta superfamily member growth-differentiation factor-15 protects the heart from ischemia/reperfusion injury. Circ Res. 2006 Feb 17;98 (3):351-60
  • Kempf T, Horn-Wichmann R, Brabant G, Peter T, Allhoff T, Klein G, Drexler H, Johnston N, Wallentin L, Wollert KC. Circulating concentrations of growth-differentiation factor 15 in apparently healthy elderly individuals and patients with chronic heart failure as assessed by a new immunoradiometric sandwich assay. Clin Chem. 2007 Feb;53 (2):284-91
  • Liu T, Bauskin AR, Zaunders J, Brown DA, Pankhurst S, Russell PJ, Breit SN. Macrophage inhibitory cytokine 1 reduces cell adhesion and induces apoptosis in prostate cancer cells. Cancer Res. 2003 Aug 15;63 (16):5034-40
  • Moore AG, Brown DA, Fairlie WD, Bauskin AR, Brown PK, Munier ML, Russell PK, Salamonsen LA, Wallace EM, Breit SN. The transforming growth factor-ss superfamily cytokine macrophage inhibitory cytokine-1 is present in high concentrations in the serum of pregnant women. J Clin Endocrinol Metab. 2000 Dec;85 (12):4781-8
  • Selander KS, Brown DA, Sequeiros GB, Hunter M, Desmond R, Parpala T, Risteli J, Breit SN, Jukkola-Vuorinen A. Serum macrophage inhibitory cytokine-1 concentrations correlate with the presence of prostate cancer bone metastases. Cancer Epidemiol Biomarkers Pr. 2007 Mar;16 (3):532-7
  • Tanno T, Bhanu NV, Oneal PA, Goh SH, Staker P, Lee YT, Moroney JW, Reed CH, Luban NL, Wang RH, Eling TE, Childs R, Ganz T, Leitman SF, Fucharoen S, Miller JL. High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin. Nat Med. 2007 Sep;13 (9):1096-101
  • Wollert KC, Kempf T, Lagerqvist B, Lindahl B, Olofsson S, Allhoff T, Peter T, Siegbahn A, Venge P, Drexler H, Wallentin L. Growth differentiation factor 15 for risk s
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By Research Topic

Cardiovascular disease
Cytokines and chemokines and related molecules
Oncology
Reproduction

By Molecule

GDF-15/MIC-1

By Technical Data

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