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Manufactured by BioVendor

Human Interleukin-36 alpha ELISA

  • Regulatory status:RUO
  • Type:Sandwich ELISA, Biotin-labelled antibody
  • Other names:IL-36 alpha, IL-1F6, FIL1-epsilon, IL­1 member epsilon
  • Species:Human
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Cat. No. Size Price


New RAG026R 96 wells (1 kit)
PubMed Product Details
Technical Data

Type

Sandwich ELISA, Biotin-labelled antibody

Applications

Serum, Plasma, Cell culture supernatant

Sample Requirements

5µl/well

Storage/Expiration

Store the complete kit at 2–8°C. Under these conditions, the kit is stable until the expiration date (see label on the box).

Calibration Range

7.8 - 500 pg/ml

Limit of Detection

4 pg/ml

Intra-assay (Within-Run)

n = 6
CV = 3.6%

Inter-assay (Run-to-Run)

n = 5
CV = 4.2%

Spiking Recovery

82 - 103%

Dilution Linearity

82 - 112%

Summary

Features

It is intended for research use only

The total assay time is less than 4 hours

The kit measures IL-36alpha in serum, plasma and cell cuture supernatant

Assay format is 96 wells

Components of the kit are provided ready to use, concentrated or dried

Research topic

Immune Response, Infection and Inflammation

Summary

IL-36α and IL-36β augmented IL-17A-mediated induction of antibacterial peptides in psoriasis. A significant increase in circulating and tissue levels of IL-36α occurs in Sjögren’s syndrome patients. An increased expression of IL-36 α and IL-36 γ, but not IL-36 β has been observed in colonic inflammatory lesions from patients with inflammatory bowel disease, more prominently in ulcerative colitis. An association between IL-36 and Th17 responses was also confirmed in Crohn’s disease, although the expression of IL-36 in this population was significantly lower than in psoriasis. All members of the IL-36 subfamily are expressed during estrous cycle and pregnancy. IL-36α has also been involved in the prognosis of hepatocellular carcinoma, where its expression correlates negatively with tumor size, degree of differentiation, and level of vascular invasion. Correspondingly, high levels of IL-36α are positively correlated to the overall survival of patients.

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