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Human sCD59 ELISA

  • Regulatory status:RUO
  • Type:Sandwich ELISA, Biotin-labelled antibody
  • Other names:CD59 glycoprotein, MAC-inhibitory protein, MAC-IP, membrane inhibitor of reactive lysis, MIRL, Protectin
  • Species:Human
Cat. No. Size Price

RHK374-01R 96 wells (1 kit)
PubMed Product Details
Technical Data


Sandwich ELISA, Biotin-labelled antibody



Sample Requirements

10 µl/well


Store the complete kit at 2–8°C. Under these conditions, the kit is stable until the expiration date (see label on the box).

Calibration Range

0.39-25 ng/ml

Limit of Detection

0.39 ng/ml



The total assay time is 3.5 hours

The kit measures sCD59 in human Plasma

Assay format is 96 wells

Components of the kit are provided ready to use or concentrated

Research topic

Cardiovascular disease, Cell surface proteins (sCD)


CD59 is a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. Complement activation ultimately leads to formation of the cytotoxic, poreforming membrane attack complex (MAC), the main effector of complement mediated tissue damage. Insertion of the MAC into cell membranes induces the release of cytokines and growth factors that promote inflammation, thrombosis, and cell proliferation. CD59 is a complement regulatory protein ubiquitously expressed on mammalian cell surfaces and it specifically inhibits MAC formation and thereby protects “self” cells from complement-mediated damage. The protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in the CD59 gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. CD59 was demonstrated to be present in plasma/serum of healthy individuals in levels ranging from 22 to 119 ng/ml.

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