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IgG Rheumatoid Factor Mouse ELISA

  • Regulatory status:RUO
  • Type:Direct ELISA, HRP-labelled antibody
  • Other names:RF-IgG
  • Species:Mouse
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RSHAKRRG101R 96 wells (1 kit)
PubMed Product Details
Technical Data

Type

Direct ELISA, HRP-labelled antibody

Applications

Serum, Plasma-EDTA, Plasma-Citrate

Sample Requirements

1 µl/well

Shipping

At ambient temperature. Upon receipt, store the product at the temperature recommended below.

Storage/Expiration

Store the complete kit at 2–8°C. Under these conditions, the kit is stable until the expiration date (see label on the box).

Calibration Curve

Calibration Range

15.6–1 000 mU/ml

Limit of Detection

0.78 mU/ml

Summary

Research topic

Animal studies

Summary

Rheumatoid factors are autoantibodies against Fc region of of IgG and is found in 70-80% of patients suffering from chronic rheumatoid arthritis, and are considered to be closely related to its pathological syndrome. Experimental animal models with spontaneous autoimmune diseases similar to those in humans, and animals with artificially-induced inflammation have been used to elucidate the mechanism of autoimmune diseases and to search for potential new remedies. A representative model animal of spontaneous autoimmune diseases is MRL/lpr mouse. As MRL/lpr shows high incidence of lymph node tumor, nephritis, angitis, and arthritis, this animal strain is useful for studies of the mechanism of human autoimmune diseases including rheumatoid arthritis.
Autoantibodies found in MRL/lpr serum are IgG type rheumatoid factor, IgM type rheumatoid factor, anti-ssDNA antibodies, anti-dsDNA antibodies, and anti-Sm antibody, etc. This kit enables quantification and comparison of IgG type rheumatoid factor with a calibration curve using standard antibody preparation.

Product References (5)

References

  • Ishihara K, Sawa S, Ikushima H, Hirota S, Atsumi T, Kamimura D, Park SJ,Murakami M, Kitamura Y, Iwakura Y, Hirano T. The point mutation of tyrosine 759of the IL-6 family cytokine receptor gp130 synergizes with HTLV-1 pX in promotingrheumatoid arthritis-like arthritis. Int Immunol. 2004 Mar;16(3):455-65. PubMedPMID: 14978019. See more on PubMed
  • Kumanogoh A, Shikina T, Watanabe C, Takegahara N, Suzuki K, Yamamoto M,Takamatsu H, Prasad DV, Mizui M, Toyofuku T, Tamura M, Watanabe D, Parnes JR,Kikutani H. Requirement for CD100-CD72 interactions in fine-tuning of B-cellantigen receptor signaling and homeostatic maintenance of the B-cell compartment.Int Immunol. 2005 Oct;17(10):1277-82. Epub 2005 Aug 19. PubMed PMID: 16113236. See more on PubMed
  • Oishi H, Mizuki S, Terada M, Kudo M, Araki K, Araki M, Nose M, Takahashi S.Increased expression of soluble form of vascular cell adhesion molecule-1aggravates autoimmune arthritis in MRL-Fas(lpr) mice. Pathol Int. 2007Nov;57(11):734-40. PubMed PMID: 17922685. See more on PubMed
  • Takeda Y, Takeno M, Iwasaki M, Kobayashi H, Kirino Y, Ueda A, Nagahama K, AokiI, Ishigatsubo Y. Chemical induction of HO-1 suppresses lupus nephritis byreducing local iNOS expression and synthesis of anti-dsDNA antibody. Clin ExpImmunol. 2004 Nov;138(2):237-44. PubMed PMID: 15498032; PubMed Central PMCID:PMC1809216. See more on PubMed
  • Yim YK, Lee H, Hong KE, Kim YI, Lee BR, Son CG, Kim JE. Electro-acupuncture atacupoint ST36 reduces inflammation and regulates immune activity inCollagen-Induced Arthritic Mice. Evid Based Complement Alternat Med. 2007Mar;4(1):51-7. Epub 2006 Aug 18. PubMed PMID: 17342241; PubMed Central PMCID:PMC1810363. See more on PubMed
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