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Immunoglobulin A (Secretory) in Stool Human ELISA

  • Regulatory status:RUO
  • Type:Sandwich ELISA, HRP-labelled antibody
  • Other names:IgA Secretory, sIgA
  • Species:Human
Cat. No. Size Price


IC6100 96 wells (1 kit) $603,75
PubMed Product Details
Technical Data

Cat # changed from RIC6100 to IC6100

Type

Sandwich ELISA, HRP-labelled antibody

Applications

Stool, Saliva

Sample Requirements

100 µl/well

Shipping

At ambient temperature. Upon receipt, store the product at the temperature recommended below.

Storage/Expiration

Store the complete kit at 2–8°C. Under these conditions, the kit is stable until the expiration date (see label on the box).

Calibration Range

600-22,2 ng/ml

Limit of Detection

3,1 ng/ml

Intra-assay (Within-Run)

5,4 %

Inter-assay (Run-to-Run)

6 %

Spiking Recovery

106,70%

Dilution Linearity

93,80%

Note

The kits are CE-IVD certified and intended for professional use.

Summary

Features

  • European Union: for in vitro diagnostic use
  • Rest of the world: for research use only!

Research topic

Autoimmunity, Immune Response, Infection and Inflammation

Summary

Secretory IgA is comprised of two immunglobuline A molecules, which are joined by a J-protein and a secretory component. The secretory component is synthesized by epithelial cells of the mucous membrane of gastrointestinal, respiratory and urogenitaltract. It is also produced by the saliva, tear and mammary glands. The plasma cells in the subendothelial area of mucous membranes are releasing a complex of two IgA-molecules, which are joined over the J-protein. This complex is binding to a secretory component, located at the surface of the epithel cell. After binding, the sIgA is transported across the cell and excreted by exocytosis. The determination of secretory IgA (sIgA) allows a first overview of the functionality of the gastrointestinal associated immune system (GALT). At this the secretory power and the degree of stimulation of the plasma cells of the intestinal submucosa is determined.

Product References (1)

References

  • Giribaldi M, Ortoffi MF, Giuffrida MG, Gastaldi D, Peila C, Coscia A, Raia M, Arslanoglu S, Moro GE, Cavallarin L, Bertino E. Effect of prolonged refrigeration on the protein and microbial profile of human milk. International Dairy Journal. August 2013;31 (2):121-6
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