Select country change
Shopping cart (0 , 0,00 ) Menu Search
Manufactured by BioVendor

Interleukin-21 Human ELISA

  • Regulatory status:RUO
  • Type:Sandwich ELISA, Biotin-labelled antibody
  • Other names:Za11, IL-21, Cytokine CX2
  • Species:Human
Please select your region to see available products and prices.
Cat. No. Size Price


RAF057R 96 wells (1 kit)
PubMed Product Details
Technical Data

Type

Sandwich ELISA, Biotin-labelled antibody

Applications

Plasma-EDTA, Plasma-Citrate, Plasma, Cell culture supernatant

Sample Requirements

50 µl/well

Shipping

At ambient temperature. Upon receipt, store the product at the temperature recommended below.

Storage/Expiration

Store the complete kit at 2–8°C. Under these conditions, the kit is stable until the expiration date (see label on the box).

Calibration Curve

Calibration Range

78–5000 pg/ml

Limit of Detection

20.0 pg/ml

Intra-assay (Within-Run)

CV = 5.8%

Inter-assay (Run-to-Run)

CV = 7.7%

Spiking Recovery

95,00%

Dilution Linearity

89,00%

Summary

Research topic

Cytokines and chemokines and related molecules

Summary

Interleukin-21 is the most recently discovered member of the type-I cytokine family. Structurally, IL-21 shows homology to IL-2, IL-4, and IL-15 proteins. IL-21 shares the common gamma-chain with these three cytokines, but, in addition, binds to a unique IL-21R alpha chain, and activates the JAK/STAT pathway.
IL-21 has pleiotropic actions, from augmenting the proliferation of T cells and driving the differentiation of B cells into memory cells and terminally differentiated plasma cells to augmenting the activity of natural killer cells. IL-21 is mainly produced by activated T-cells, but targets a broad range of lymphoid and myeloid cells of the immune system and therefore is able to regulate innate and acquired immune responses.
IL-21 has pathologic function in immune-inflammatory diseases. Data suggest the existence of a positive autocrine loop that could help to amplify and stabilize IL-21-driven, T cell-mediated responses.
Moreover, it has antitumour activity and may have a role in the development of autoimmunity. IL-21 may have therapeutic potentials as an antitumor agent in the clinic.

Product References (1)

References

  • Li N, Zhu Q, Li Z, Han Q, Chen J, Lv Y, Wang Y, Zeng X, Chen Y, Yang C, Liu Z.IL21 and IL21R polymorphisms and their interactive effects on serum IL-21 and IgElevels in patients with chronic hepatitis B virus infection. Hum Immunol. 2013May;74(5):567-73. doi: 10.1016/j.humimm.2013.01.005. Epub 2013 Jan 24. PubMedPMID: 23354321. See more on PubMed
Related Products Docs