Type
Sandwich ELISA, Biotin-labelled antibody
Applications
Serum, Plasma-Citrate, Cell culture supernatant
Sample Requirements
50 µl/well
Shipping
At ambient temperature. Upon receipt, store the product at the temperature recommended below.
Storage/Expiration
Store the complete kit at 2–8°C. Under these conditions, the kit is stable until the expiration date (see label on the box).
Calibration Curve
Calibration Range
31.3–2000 pg/ml
Limit of Detection
16.0 pg/ml
Research topic
Cytokines and chemokines and related molecules, Animal studies
Summary
Interleukin-23 was found during a genome scan for the IL-6/IL-12 cytokine family. IL-23 protein is a heterodimer, sharing a p40 subunit with IL-12, but having a distinct p19 subunit, which is IL-23 specific. IL-23 uses many of the same signal-transduction components as IL-12, so it binds to IL-12Rβ1 receptor, but not IL-12Rβ2.
IL-23 plays a role in type 1-polarized T-cell immune responses. Although IL-12 strongly activates naïve T-cells, the initial description of IL-23 reported preferential actions on memory T-cells to increase IFN-γ production and proliferation suggesting an important role for IL-23 in controlling bacterial infections. IL-23 has further been described as a key cytokine controlling inflammation in peripheral tissues. Overexpression of p19 correlates with inflammation in multiple organs and epithelial tissues including skin. IL-23 was shown to be involved in inflammation of the nervous system and autoimmune diseases.
Find documents for the lot
Example Instructions for Use (RUO)
Example Instructions for Use (RUO)
Safety Information (RUO)
MSDS (RUO)
