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Interleukin-23 Mouse ELISA

  • Regulatory status:RUO
  • Type:Sandwich ELISA, Biotin-labelled antibody
  • Other names:IL-23, IL-23P19, IL-23A, JKA3 induced upon T cell activation, SGRF, IL-23 p40, CLMF p40, CLMF 2, Cytotoxic lymphocyte maturation factor 2, NK cell stimulatory factor chain 2, T-cell stimulating factor
  • Species:Mouse
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Cat. No. Size Price


RAF061R 96 wells (1 kit)
PubMed Product Details
Technical Data

Type

Sandwich ELISA, Biotin-labelled antibody

Applications

Serum, Plasma-Citrate, Cell culture supernatant

Sample Requirements

50 µl/well

Shipping

At ambient temperature. Upon receipt, store the product at the temperature recommended below.

Storage/Expiration

Store the complete kit at 2–8°C. Under these conditions, the kit is stable until the expiration date (see label on the box).

Calibration Curve

Calibration Range

31.3–2000 pg/ml

Limit of Detection

16.0 pg/ml

Summary

Research topic

Cytokines and chemokines and related molecules, Animal studies

Summary

Interleukin-23 was found during a genome scan for the IL-6/IL-12 cytokine family. IL-23 protein is a heterodimer, sharing a p40 subunit with IL-12, but having a distinct p19 subunit, which is IL-23 specific. IL-23 uses many of the same signal-transduction components as IL-12, so it binds to IL-12Rβ1 receptor, but not IL-12Rβ2.
IL-23 plays a role in type 1-polarized T-cell immune responses. Although IL-12 strongly activates naïve T-cells, the initial description of IL-23 reported preferential actions on memory T-cells to increase IFN-γ production and proliferation suggesting an important role for IL-23 in controlling bacterial infections. IL-23 has further been described as a key cytokine controlling inflammation in peripheral tissues. Overexpression of p19 correlates with inflammation in multiple organs and epithelial tissues including skin. IL-23 was shown to be involved in inflammation of the nervous system and autoimmune diseases.

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