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Manufactured by BioVendor

Irisin ELISA

  • Regulatory status:RUO
  • Type:Competitive ELISA, Immobilized antigen
  • Other names:Fibronectin Type III Domain-containing Protein 5, Fibronectin Type III Repeat-containing Protein 2, FNDC5
  • Species:Human
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Cat. No. Size Price

RAG018R 96 wells (1 kit)
PubMed Product Details
Technical Data


Competitive ELISA, Immobilized antigen


Serum, Plasma, Cell culture supernatant


At ambient temperature. Upon receipt, store the product at the temperature recommended below.


Store the complete kit at 2–8°C. Under these conditions, the kit is stable until the expiration date (see label on the box).

Calibration Curve

Calibration Range

0.001–5 μg/ml

Limit of Detection

1 ng/ml


Research topic

Energy metabolism and body weight regulation


Irisin is a recently described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin activates beige fat cells (beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone Irisin). Irisin is cleaved from the type I membrane protein FNDC5 and improves systemic metabolism by increasing energy expenditure. Circulating irisin levels were shown to be upregulated after acute exercise. Increase of irisin under conditions of obesity may indicate a physiological function to improve glucose tolerance.

Product References (15)


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  • Lee YJ, Heo Y, Choi JH, Park S, Kim KK, Shin DW, Kang JH. Association ofCirculating Irisin Concentrations with Weight Loss after Roux-en-Y Gastric BypassSurgery. Int J Environ Res Public Health. 2019 Feb 24;16(4). pii: E660. doi:10.3390/ijerph16040660. PubMed PMID: 30813469; PubMed Central PMCID: PMC6406479. See more on PubMed
  • Leung WKC, Yu AP, Lai CWK, Siu PM. Association of Markers of ProinflammatoryPhenotype and Beige Adipogenesis with Metabolic Syndrome in Chinese CentrallyObese Adults. J Diabetes Res. 2018 Feb 18;2018:8956509. doi:10.1155/2018/8956509. eCollection 2018. PubMed PMID: 29670915; PubMed CentralPMCID: PMC5835251. See more on PubMed
  • Martínez Muñoz IY, Camarillo Romero EDS, Correa Padilla T, Santillán BenítezJG, Camarillo Romero MDS, Montenegro Morales LP, Bravo GGH, Garduño García JJ.Association of Irisin Serum Concentration and Muscle Strength in Normal-Weightand Overweight Young Women. Front Endocrinol (Lausanne). 2019 Sep 13;10:621. doi:10.3389/fendo.2019.00621. eCollection 2019. PubMed PMID: 31572302; PubMed CentralPMCID: PMC6753374. See more on PubMed
  • Mól N, Zasada M, Tomasik P, Klimasz K, Kwinta P. Evaluation of irisin andvisfatin levels in very low birth weight preterm newborns compared to full termnewborns-A prospective cohort study. PLoS One. 2018 Sep 27;13(9):e0204835. doi:10.1371/journal.pone.0204835. eCollection 2018. PubMed PMID: 30261060; PubMedCentral PMCID: PMC6160155. See more on PubMed
  • Ochman M, Maruszewski M, Wojarski J, Żegleń S, Karolak W, Stanjek-CichorackaA, Przybyłowski P, Zembala M, Kukla M. Serum Levels of Visfatin, Omentin andIrisin in Patients with End-Stage Lung Disease Before and After LungTransplantation. Ann Transplant. 2017 Dec 26;22:761-768. PubMed PMID: 29277835;PubMed Central PMCID: PMC6248051. See more on PubMed
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