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Manufactured by BioVendor

Irisin ELISA

  • Regulatory status:RUO
  • Type:Competitive ELISA, Immobilized antigen
  • Other names:Fibronectin Type III Domain-containing Protein 5, Fibronectin Type III Repeat-containing Protein 2, FNDC5
  • Species:Human
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Cat. No. Size Price


RAG018R 96 wells (1 kit)
PubMed Product Details
Technical Data

Type

Competitive ELISA, Immobilized antigen

Applications

Serum, Plasma, Cell culture supernatant

Shipping

At ambient temperature. Upon receipt, store the product at the temperature recommended below.

Storage/Expiration

Store the complete kit at 2–8°C. Under these conditions, the kit is stable until the expiration date (see label on the box).

Calibration Curve

Calibration Range

0.001–5 μg/ml

Limit of Detection

1 ng/ml

Summary

Research topic

Energy metabolism and body weight regulation

Summary

Irisin is a recently described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin activates beige fat cells (beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone Irisin). Irisin is cleaved from the type I membrane protein FNDC5 and improves systemic metabolism by increasing energy expenditure. Circulating irisin levels were shown to be upregulated after acute exercise. Increase of irisin under conditions of obesity may indicate a physiological function to improve glucose tolerance.

Product References (12)

References

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  • Dupas J, Feray A, Guernec A, Pengam M, Inizan M, Guerrero F, Mansourati J,Goanvec C. Effect of personalized moderate exercise training on Wistar rats fedwith a fructose enriched water. Nutr Metab (Lond). 2018 Oct 3;15:69. doi:10.1186/s12986-018-0307-6. eCollection 2018. PubMed PMID: 30305835; PubMedCentral PMCID: PMC6171221. See more on PubMed
  • Engin-Üstün Y, Çağlayan EK, Göçmen AY, Polat MF. Postmenopausal OsteoporosisIs Associated with Serum Chemerin and Irisin but Not with Apolipoprotein MLevels. J Menopausal Med. 2016 Aug;22(2):76-9. doi: 10.6118/jmm.2016.22.2.76.Epub 2016 Aug 30. PubMed PMID: 27617241; PubMed Central PMCID: PMC5016507. See more on PubMed
  • Lavrova DP, Zavodovsky BV, Akhverdyan YR, Polyakova YV, Sivordova LE,Zborovskaya IA, Yakovlev AT. [Irisin as a new marker for the early diagnosis oflow-traumatic fractures in rheumatoid arthritis.]. Klin Lab Diagn.2018;63(11):702-706. doi: 10.18821/0869-2084-2018-63-11-702-706. Russian. PubMed PMID: 30776205. See more on PubMed
  • Leung WKC, Yu AP, Lai CWK, Siu PM. Association of Markers of ProinflammatoryPhenotype and Beige Adipogenesis with Metabolic Syndrome in Chinese CentrallyObese Adults. J Diabetes Res. 2018 Feb 18;2018:8956509. doi:10.1155/2018/8956509. eCollection 2018. PubMed PMID: 29670915; PubMed CentralPMCID: PMC5835251. See more on PubMed
  • Mól N, Zasada M, Tomasik P, Klimasz K, Kwinta P. Evaluation of irisin andvisfatin levels in very low birth weight preterm newborns compared to full termnewborns-A prospective cohort study. PLoS One. 2018 Sep 27;13(9):e0204835. doi:10.1371/journal.pone.0204835. eCollection 2018. PubMed PMID: 30261060; PubMedCentral PMCID: PMC6160155. See more on PubMed
  • Ochman M, Maruszewski M, Wojarski J, Żegleń S, Karolak W, Stanjek-CichorackaA, Przybyłowski P, Zembala M, Kukla M. Serum Levels of Visfatin, Omentin andIrisin in Patients with End-Stage Lung Disease Before and After LungTransplantation. Ann Transplant. 2017 Dec 26;22:761-768. PubMed PMID: 29277835;PubMed Central PMCID: PMC6248051. See more on PubMed
  • Ökdemir D, Hatipoğlu N, Kurtoğlu S, Siraz ÜG, Akar HH, Muhtaroğlu S, Kütük MS.The Role of Irisin, Insulin and Leptin in Maternal and Fetal Interaction. J Clin Res Pediatr Endocrinol. 2018 Nov 29;10(4):307-315. doi: 10.4274/jcrpe.0096. Epub 2018 May 29. PubMed PMID: 29809159; PubMed Central PMCID: PMC6280331. See more on PubMed
  • Polyzos SA, Kountouras J, Anastasilakis AD, Geladari EV, Mantzoros CS. Irisin in patients with nonalcoholic fatty liver disease. Metabolism. 2014Feb;63(2):207-17. doi: 10.1016/j.metabol.2013.09.013. Epub 2013 Oct 18. PubMedPMID: 24140091. See more on PubMed
  • Bubak MP, Heesch MWS, Shute RJ, Dinan NE, Laursen TL, LA Salle DT, Slivka DR. Irisin and Fibronectin Type III Domain-Containing 5 Responses to Exercise inDifferent Environmental Conditions. Int J Exerc Sci. 2017 Sep 1;10(5):666-680.eCollection 2017. PubMed PMID: 28966707; PubMed Central PMCID: PMC5609670. See more on PubMed
  • Lee YJ, Heo Y, Choi JH, Park S, Kim KK, Shin DW, Kang JH. Association ofCirculating Irisin Concentrations with Weight Loss after Roux-en-Y Gastric BypassSurgery. Int J Environ Res Public Health. 2019 Feb 24;16(4). pii: E660. doi:10.3390/ijerph16040660. PubMed PMID: 30813469; PubMed Central PMCID: PMC6406479. See more on PubMed
  • Sancak S, Aydın H, Sargin M, Orçun A, Özdemir A, Çelik A, Sunar B, Aslan G.SERUM IRISIN LEVEL INCREASES THROUGHOUT THE GESTATIONAL PERIOD AND IT DOES NOTPLAY A ROLE IN DEVELOPMENT OF GESTATIONAL DIABETES MELLITUS. Acta Endocrinol(Buchar). 2017 Oct-Dec;13(4):393-399. doi: 10.4183/aeb.2017.393. PubMed PMID:31149207; PubMed Central PMCID: PMC6516544. See more on PubMed
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