Type
Competitive ELISA, Immobilized antigen
Applications
Serum, Plasma, Cell culture supernatant
Shipping
At ambient temperature. Upon receipt, store the product at the temperature recommended below.
Storage/Expiration
Store the complete kit at 2–8°C. Under these conditions, the kit is stable until the expiration date (see label on the box).
Calibration Curve
Calibration Range
0.001–5 μg/ml
Limit of Detection
1 ng/ml
Research topic
Energy metabolism and body weight regulation
Summary
Irisin is a recently described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin activates beige fat cells (beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone Irisin). Irisin is cleaved from the type I membrane protein FNDC5 and improves systemic metabolism by increasing energy expenditure. Circulating irisin levels were shown to be upregulated after acute exercise. Increase of irisin under conditions of obesity may indicate a physiological function to improve glucose tolerance.
Instructions for Use (RUO)
Instructions for Use (RUO)
Safety Information (RUO)
MSDS (RUO)
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