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Irisin ELISA

  • Regulatory status:RUO
  • Type:Competitive ELISA, Immobilized antigen
  • Other names:Fibronectin Type III Domain-containing Protein 5, Fibronectin Type III Repeat-containing Protein 2, FNDC5
  • Species:Human
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Cat. No. Size Price


RAG018R 96 wells (1 kit)
PubMed Product Details
Technical Data

Type

Competitive ELISA, Immobilized antigen

Applications

Serum, Plasma, Cell culture supernatant

Shipping

At ambient temperature. Upon receipt, store the product at the temperature recommended below.

Storage/Expiration

Store the complete kit at 2–8°C. Under these conditions, the kit is stable until the expiration date (see label on the box).

Calibration Curve

Calibration Range

0.001–5 μg/ml

Limit of Detection

1 ng/ml

Summary

Research topic

Energy metabolism and body weight regulation

Summary

Irisin is a recently described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin activates beige fat cells (beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone Irisin). Irisin is cleaved from the type I membrane protein FNDC5 and improves systemic metabolism by increasing energy expenditure. Circulating irisin levels were shown to be upregulated after acute exercise. Increase of irisin under conditions of obesity may indicate a physiological function to improve glucose tolerance.

References to Product

References

  • Belviranli M, Okudan N, Kabak B, Erdogan M, Karanfilci M. The relationship between brain-derived neurotrophic factor, irisin and cognitive skills of endurance athletes. Phys Sportsmed. 2016 Jun 2;
  • Dupas J, Feray A, Guernec A, et al. Effect of personalized moderate exercise training on Wistar rats fed with a fructose enriched water. Nutr Metab (Lond). 2018;15:69. Published 2018 Oct 3. doi:10.1186/s12986-018-0307-6
  • Engin-Ustun Y, Caglayan EK, Gocmen AY, Polat MF. Postmenopausal Osteoporosis Is Associated with Serum Chemerin and Irisin but Not with Apolipoprotein M Levels. J Menopausal Med. 2016 Aug;22 (2):76-9
  • Lavrova DP, Zavodovsky BV, Akhverdyan YR, Polyakova YV, Sivordova LE,Zborovskaya IA, Yakovlev AT. [Irisin as a new marker for the early diagnosis of low-traumatic fractures in rheumatoid arthritis.]. Klin Lab Diagn. 2018;63(11):702-706. doi: 10.18821/0869-2084-2018-63-11-702-706.
  • Leung WKC, Yu AP, Lai CWK, Siu PM. Association of Markers of Proinflammatory Phenotype and Beige Adipogenesis with Metabolic Syndrome in Chinese Centrally Obese Adults. J Diabetes Res. 2018;2018:8956509. Published 2018 Feb 18. doi:10.1155/2018/8956509
  • Mól N, Zasada M, Tomasik P, Klimasz K, Kwinta P. Evaluation of irisin and visfatin levels in very low birth weight preterm newborns compared to full term newborns-A prospective cohort study. PLoS One. 2018;13(9):e0204835. Published 2018 Sep 27. doi:10.1371/journal.pone.0204835
  • Ochman M, Maruszewski M, Wojarski J, et al. Serum Levels of Visfatin, Omentin and Irisin in Patients with End-Stage Lung Disease Before and After Lung Transplantation. Ann Transplant. 2017;23:765–772. Published 2017 Dec 26. doi:10.12659/AOT.904994
  • Ökdemir D, Hatipoğlu N, Kurtoğlu S, et al. The Role of Irisin, Insulin and Leptin in Maternal and Fetal Interaction. J Clin Res Pediatr Endocrinol. 2018;10(4):307-315.
  • Polyzos SA, Kountouras J, Anastasilakis AD, Geladari EV, Mantzoros CS. Irisin in patients with nonalcoholic fatty liver disease. Metabolism. 2014 Feb;63 (2):207-17
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