Type
Latex Agglutination Assay
Applications
Serum, Plasma
Sample Requirements
2 µL
Storage/Expiration
Store all components of this kit at 2-10°C.
Calibration Range
70-10,000 U/mL
Cat. No. | Size |
Price |
|
---|---|---|---|
New KL-6(II) | 1 kit |
Latex Agglutination Assay
Serum, Plasma
2 µL
Store all components of this kit at 2-10°C.
70-10,000 U/mL
Immune Response, Infection and Inflammation, Oncology, Pulmonary diseases, COVID-19
Sialylated carbohydrate antigen KL-6 found by Kohno in 1985 is one of the sialylated carbohydrate antigen located on MUC1, over 1 million molecular weight and transmembrane type glycoprotein expressed on epithelial cell line1. At the beginning of his study, he prepared monoclonal antibody by immunizing (VMRC-LCR) cell derived from human lung adenocarcinoma to mice with the aim of developing lung cancer marker. However, this antibody was specific to interstitial pneumonia and showed higher values in the active phase of interstitial pneumonia when react with patient sera, and was named KL-6 for the antigen and the antibody. In patients with interstitial pneumonia affected alveolar epithelium, KL-6 indicates remarkably higher values than in healthy people and other respiratory diseases. For this reason, KL-6 had been recognized as high diagnostic utility for interstitial pneumonia and pulmonary fibrosis, until then it was poor in specific markers for these diseases. Furthermore, in active interstitial pneumonia cases KL-6 showed significantly higher value compared to the non-active cases and vary to reflect the disease after the start of treatment. Thus, measurement of the KL-6 is used for the purpose of differentiation of pathologies characterized by fibrosis of the lungs, pathological state of interstitial pneumonia (active and inactive of differentiation) and observation of treatment.