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Leptin Human ELISA, Clinical Range

  • Regulatory status:RUO
  • Type:Sandwich ELISA, HRP-labelled antibody
  • Other names:Obesity factor, Obese protein, LEP, OB, OBS
  • Species:Human
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Cat. No. Size Price


RD191001100 96 wells (1 kit)
PubMed Product Details
Technical Data

Type

Sandwich ELISA, HRP-labelled antibody

Applications

Serum, Plasma-EDTA, Plasma-Heparin, Plasma-Citrate

Sample Requirements

35 µl/well

Shipping

At ambient temperature. Upon receipt, store the product at the temperature recommended below.

Storage/Expiration

Store the kit at 2–8°C. Under these conditions, the kit is stable until the expiration date (see label on the box).

Calibration Curve

Calibration Range

1-50 ng/ml

Limit of Detection

0.2 ng/ml

Intra-assay (Within-Run)

n=8, CV = 5.9%

Inter-assay (Run-to-Run)

n=6, CV = 5.6%

Spiking Recovery

92.1%

Dilutation Linearity

100.8%

Crossreactivity

  • bovine Non-detectable
  • cat Non-detectable
  • dog Non-detectable
  • goat Non-detectable
  • hamster Non-detectable
  • horse Non-detectable
  • monkey Non-detectable
  • mouse Non-detectable
  • pig Non-detectable
  • rabbit Non-detectable
  • rat Non-detectable
  • sheep Non-detectable
  • chicken Not tested
  • human Yes
Summary

Features

  • European Union: for in vitro diagnostic use
  • Rest of the world: for research use only!
  • The total assay time is less than 2.5 hours
  • The kit measures total leptin
  • Assay format is 96 wells
  • Quality Controls are human serum based
  • Standards are recombinant protein based
  • Components of the kit are provided ready to use, concentrated or lyophilized

Research topic

Diabetology - Other Relevant Products, Energy metabolism and body weight regulation, Reproduction

Summary

Leptin, the product of the ob (obese) gene, is a single-chain 16 kDa protein consisting of 146
amino acid residues. Leptin is produced mainly in the adipose tissue, and is considered to play
an important role in appetite control, fat metabolism and body weight regulation. It targets the
central nervous system, particularly hypothalamus, affecting food intake. The primary effect of
leptin appears to be mediated by leptin receptors expressed mainly in the hypothalamus. In
humans, leptin levels correlate with body mass index (BMI) and percentage body fat, and are
elevated even in obese individuals. Leptin has a dual action; it decreases the appetite and
increases energy consumption, causing more fat to be burned. Leptin is secreted in circadian
fashion with nocturnal rise in both lean and obese patients.

Mutations of the ob gene resulting in leptin deficiency are the cause of obesity in the ob/ob
mice. Endogeneous leptin can normalize their body weight. In contrast, high levels of leptin in
obese human subjects point to an insensitivity to endogeneous leptin.
Other factors in addition to the amount of body fat appear to regulate leptin action: insulin,
glucocorticoids, catecholamines and sex hormones. Studies have shown that leptin may be
linked to reproductive function.

References to Product

References

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References to Summary

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