Select country change
Shopping cart (0 , 0,00 ) Menu Search
Manufactured by BioVendor

Leptin Human ELISA, Clinical Range

  • Regulatory status:RUO
  • Type:Sandwich ELISA, HRP-labelled antibody
  • Other names:Obesity factor, Obese protein, LEP, OB, OBS
  • Species:Human
Please select your region to see available products and prices.
Cat. No. Size Price

RD191001100 96 wells (1 kit)
PubMed Product Details
Technical Data


Sandwich ELISA, HRP-labelled antibody


Serum, Plasma-EDTA, Plasma-Heparin, Plasma-Citrate

Sample Requirements

35 µl/well


At ambient temperature. Upon receipt, store the product at the temperature recommended below.


Store the kit at 2–8°C. Under these conditions, the kit is stable until the expiration date (see label on the box).

Calibration Curve

Calibration Range

1-50 ng/ml

Limit of Detection

0.2 ng/ml

Intra-assay (Within-Run)

n=8, CV = 5.9%

Inter-assay (Run-to-Run)

n=6, CV = 5.6%

Spiking Recovery


Dilutation Linearity



  • bovine Non-detectable
  • cat Non-detectable
  • dog Non-detectable
  • goat Non-detectable
  • hamster Non-detectable
  • horse Non-detectable
  • monkey Non-detectable
  • mouse Non-detectable
  • pig Non-detectable
  • rabbit Non-detectable
  • rat Non-detectable
  • sheep Non-detectable
  • chicken Not tested
  • human Yes


  • European Union: for in vitro diagnostic use
  • Rest of the world: for research use only!
  • The total assay time is less than 2.5 hours
  • The kit measures total leptin
  • Assay format is 96 wells
  • Quality Controls are human serum based
  • Standards are recombinant protein based
  • Components of the kit are provided ready to use, concentrated or lyophilized

Research topic

Diabetology - Other Relevant Products, Energy metabolism and body weight regulation, Reproduction


Leptin, the product of the ob (obese) gene, is a single-chain 16 kDa protein consisting of 146
amino acid residues. Leptin is produced mainly in the adipose tissue, and is considered to play
an important role in appetite control, fat metabolism and body weight regulation. It targets the
central nervous system, particularly hypothalamus, affecting food intake. The primary effect of
leptin appears to be mediated by leptin receptors expressed mainly in the hypothalamus. In
humans, leptin levels correlate with body mass index (BMI) and percentage body fat, and are
elevated even in obese individuals. Leptin has a dual action; it decreases the appetite and
increases energy consumption, causing more fat to be burned. Leptin is secreted in circadian
fashion with nocturnal rise in both lean and obese patients.

Mutations of the ob gene resulting in leptin deficiency are the cause of obesity in the ob/ob
mice. Endogeneous leptin can normalize their body weight. In contrast, high levels of leptin in
obese human subjects point to an insensitivity to endogeneous leptin.
Other factors in addition to the amount of body fat appear to regulate leptin action: insulin,
glucocorticoids, catecholamines and sex hormones. Studies have shown that leptin may be
linked to reproductive function.

Product References (108)


  • Adam JA, Menheere PP, van Dielen FM, Soeters PB, Buurman WA, Greve JW. Decreased plasma orexin-A levels in obese individuals. Int J Obes Relat Metab Disord . 26(2):274-6 (2002)
  • Adamska-Patruno E, Ostrowska L, Goscik J, Pietraszewska B, Kretowski A, Gorska M. The relationship between the leptin/ghrelin ratio and meals with various macronutrient contents in men with different nutritional status: a randomized crossover study. Nutr J. 2018;17(1):118. Published 2018 Dec 28. doi:10.1186/s12937-018-0427-x
  • Aeberli I, Beljean N, Lehmann R, I'Allemand D, Spinas GA, Zimmermann MB. The increase of fatty acid-binding protein aP2 in overweight and obese children: interactions with dietary fat and impact on measures of subclinical inflammation. Int J Obes (Lond). 2008 Oct;32 (10):1513-20
  • Arnold T, Brandlhofer S, Vrtikapa K, Stangl H, Hermann M, Zwiauer K, Mangge H, Karwautz A, Huemer J, Koller D, Schneider WJ, Strobl W. Effect of obesity on plasma clusterin: a proposed modulator of leptin action. Pediatr Res. 2011 Mar;69 (3):237-42
  • Aydin HI, Yozgat Y, Demirkaya E, Olgun A, Okutan V, Lenk MK, Ozcan O. Correlation between vascular endothelial growth factor and leptin in children with cyanotic congenital heart disease. Turk J Pediatr. 2007 Oct-Dec;49 (4):360-4
  • Azzoni L, Crowther NJ, Firnhaber C, Foulkes AS, Yin X, Glencross D, Gross R, Kaplan MD, Papasavvas E, Schulze D, Stevens W, van der Merwe T, Waisberg R, Sanne I, Montaner LJ. Association between HIV replication and serum leptin levels: an observational study of a cohort of HIV-1-infected South African women. J Int AIDS Soc. 2010;13 (1):33
  • Baeza I, Vigo L, de la Serna E, Calvo-Escalona R, Merchan-Naranjo J, Rodriguez-Latorre P, Arango C, Castro-Fornieles J. The effects of antipsychotics on weight gain, weight-related hormones and homocysteine in children and adolescents: a 1-year follow-up study. Eur Child Adolesc Psychiatry. 2016 May 21;
  • Bahijri SM, Ajabnoor G, Hegazy GA, et al. Supplementation with Oligonol, Prevents Weight Gain and Improves Lipid Profile in Overweight and Obese Saudi Females. Curr Nutr Food Sci. 2018;14(2):164-170.
  • Bartek J, Stejskal D, Stejskal P, Oral I. Concentration of soluble leptin receptor in population. Acta Univ. Palacki. Olomuc.Fac. Med. Volume 144 (2000)
  • Ben Yahia R, Lichnovska R, Gwozdiewiczova S, Kuzmina G, Chlup R, Luza J, Karpisek M, Brychta T, Petrek J. Fatty Acid Binding Proteins (FABPS) in relation to significant metabolic syndrome markers in diabetic patients and non-diabetic persons - pilot study. Int J Obesity . 29: S1-S19
  • Bronsky J, Karpisek M, Bronska E, Pechova M, Jancikova B, Kotolova H, Stejskal D, Prusa R, Nevoral J. Adiponectin, adipocyte fatty acid binding protein, and epidermal fatty acid binding protein: proteins newly identified in human breast milk. Clin Chem . Sep;52(9):1763-70 (2006)
  • Bronsky J, Mitrova K, Karpisek M, Mazoch J, Durilova M, Fisarkova B, Stechova K, Prusa R, Nevoral J. Adiponectin, AFABP, and leptin in human breast milk during 12 months of lactation. J Pediatr Gastroenterol Nutr. 2011 Apr;52 (4):474-7
  • Buzga M, Evzen M, Pavel K, Tomas K, Vladislava Z, Pavel Z, Svagera Z. Effects of the Intragastric Balloon MedSil(R) on Weight Loss, Fat Tissue, Lipid Metabolism, and Hormones Involved in Energy Balance. Obes Surg. 2014 Feb 1;
  • Cagnacci A, Arangino S, Caretto S, Mazza V, Volpe A. Sexual dimorphism in the levels of amniotic fluid leptin in pregnancies at 16 weeks of gestation: relation to fetal growth. Eur J Obstet Gynecol Reprod Biol . Jan 1;124(1):53-7 (2006)
  • Cambuli VM, Musiu MC, Incani M, Paderi M, Serpe R, Marras V, Cossu E, Cavallo MG, Mariotti S, Loche S, Baroni MG. Assessment of adiponectin and leptin as biomarkers of positive metabolic outcomes after lifestyle intervention in overweight and obese children. J Clin Endocrinol Metab. 2008 Aug;93 (8):3051-7
  • Capel F, Klimcakova E, Viguerie N, Roussel B, Vitkova M, Kovacikova M, Polak J, Kovacova Z, Galitzky J, Maoret JJ, Hanacek J, Pers TH, Bouloumie A, Stich V, Langin D. Macrophages and adipocytes in human obesity: adipose tissue gene expression and insulin sensitivity during calorie restriction and weight stabilization. Diabetes. 2009 Jul;58 (7):1558-67
  • Cinkajzlova A, Lacinova Z, Klouckova J, Kavalkova P, Trachta P, Kosak M, Haluzikova D, Papezova H, Mraz M, Haluzik M. Angiopoietin-like protein 6 in patients with obesity, type 2 diabetes mellitus, and anorexia nervosa: The influence of very low-calorie diet, bariatric surgery, and partial realimentation. Endocr Res. 2016 May 2;:1-9
  • Cinkajzlová A, Mráz M, Lacinová Z, et al. Angiopoietin-like protein 3 and 4 in obesity, type 2 diabetes mellitus, and malnutrition: the effect of weight reduction and realimentation. Nutr Diabetes. 2018;8(1):21. Published 2018 Apr 25. doi:10.1038/s41387-018-0032-2
  • Creutzberg EC, Wouters EF, Vanderhoven-Augustin IM, Dentener MA, Schols AM. Disturbances in leptin metabolism are related to energy imbalance during acute exacerbations of chronic obstructive pulmonary disease. Am J Respir Crit Care Med . Oct;162(4 Pt 1):1239-45 (2000)
  • Dayer D, Nikbakht R, Kadkhodai Elyaderani M. Comparison of leptin concentrations between infertile women with polycystic ovary syndrome and fertile women. Iran J Reprod Med. 2013;11(12):1033-4.
  • Diez ML, Santolaria F, Tejera A, Aleman MR, Gonzalez-Reimers E, Milena A, de la Vega MJ, Martinez-Riera A. Serum leptin levels in community acquired pneumonia (CAP) are related to nutritional status and not to acute phase reaction. Cytokine. 2008 May;42 (2):156-60
  • Ding Q, Mracek T, Gonzalez-Muniesa P, Kos K, Wilding J, Trayhurn P, Bing C. Identification of macrophage inhibitory cytokine-1 in adipose tissue and its secretion as an adipokine by human adipocytes. Endocrinology. 2009 Apr;150 (4):1688-96
  • Disse E, Graeppi-Dulac J, Joncour-Mills G, Dupuis O, Thivolet C. Heterogeneity of pregnancy outcomes and risk of LGA neonates in Caucasian females according to IADPSG criteria for gestational diabetes mellitus. Diabetes Metab. 2013 Apr;39 (2):132-8
  • Dolinkova M, Dostalova I, Lacinova Z, Michalsky D, Haluzikova D, Mraz M, Kasalicky M, Haluzik M. The endocrine profile of subcutaneous and visceral adipose tissue of obese patients. Mol Cell Endocrinol. 2008 Sep 10;291 (1-2):63-70
  • Dostalova I, Kavalkova P, Haluzikova D, Lacinova Z, Mraz M, Papezova H, Haluzik M. Plasma concentrations of fibroblast growth factors 19 and 21 in patients with anorexia nervosa. J Clin Endocrinol Metab. 2008 Jun 17;
  • Dostalova I, Kavalkova P, Papezova H, Domluvilova D, Zikan V, Haluzik M. Association of macrophage inhibitory cytokine-1 with nutritional status, body composition and bone mineral density in patients with anorexia nervosa: the influence of partial realimentation. Nutr Metab (Lond). 2010;7:34
  • Dumon C, Diabira D, Chudotvorova I, et al. The adipocyte hormone leptin sets the emergence of hippocampal inhibition in mice. Elife. 2018;7:e36726. Published 2018 Aug 14. doi:10.7554/eLife.36726
  • Durovcova V, Marek J, Hana V, Matoulek M, Zikan V, Haluzikova D, Kavalkova P, Lacinova Z, Krsek M, Haluzik M. Plasma concentrations of adipocyte fatty acid binding protein in patients with Cushing's syndrome. Physiol Res. 2010;59 (6):963-71
  • Elie AGIM, Bloksgaard M, Sun WY, et al. Local enrichment of fatty acid-binding protein 4 in the pericardial cavity of cardiovascular disease patients. PLoS One. 2018;13(11):e0206802. Published 2018 Nov 5. doi:10.1371/journal.pone.0206802
  • Elolemy GG, Ganeb SS, Abou Ghanima AT, Abdelgwad ER. Influence of adipocytokines and IL-6 on ankylosing spondylitis disease activity and functional status. Eg Rheumatol Int. April 2013;35 (2):65-70
  • Fernandez-Rodriguez CM, Lopez-Serrano P, Alonso S, Gutierrez ML, Lledo JL, Perez-Calle JL, Temino R, Cacho G, Nevado M, Casas ML, Gasalla JM, Bonet B. Long-term reversal of hypocholesterolaemia in patients with chronic hepatitis C is related to sustained viral response and viral genotype. Aliment Pharmacol Ther . Aug 1;24(3):507-12 (2006)
  • Florentin M, Liberopoulos EN, Tellis CC, Derdemezis CS, Elisaf M, Tselepis A. Effects of Rimonabant, as Monotherapy and in Combination With Fenofibrate or Ezetimibe, on Plasma Adipokine Levels: A Pilot Study. Angiology. 2009 Nov 18;
  • Fryczkowski M, Bułdak RJ, Hejmo T, Kukla M, Żwirska-Korczala K. Circulating Levels of Omentin, Leptin, VEGF, and HGF and Their Clinical Relevance with PSA Marker in Prostate Cancer. Dis Markers. 2018;2018:3852401. Published 2018 Aug 16. doi:10.1155/2018/3852401
  • Giapros V, Evagelidou E, Challa A, Kiortsis D, Drougia A, Andronikou S. Serum adiponectin and leptin levels and insulin resistance in children born large for gestational age are affected by the degree of overweight. Clin Endocrinol (Oxf) . Mar;66(3):353-9 (2007)
  • Gilbert T, Roche S, Blond E, et al. Association between Peripheral Leptin and Adiponectin Levels and Cognitive Decline in Patients with Neurocognitive Disorders ≥65 Years. J Alzheimers Dis. 2018;66(3):1255-1264.
  • Haluzik M, Fiedler J, Nedvidkova J, Ceska R. Serum leptin levels in patients with hyperlipidemias. Nutrition . 16(6):429-33 (2000)
  • Haluzik M, Markova M, Slaby JJ, Jiskra J, Krizova J, Hass T. The changes of serum leptin and soluble leptin receptor levels in patients undergoing mobilization of peripheral blood stem cells before autologous stem cells transplantation. Endocr Res . Aug;28(3):189-97 (2002)
  • Haluzik M, Matoulek M, Svacina S, Hilgertova J, Haas T. The influence of short-term fasting on serum leptin levels, and selected hormonal and metabolic parameters in morbidly obese and lean females. Endocr Res Feb-May;27(1-2):251-60 (2001)
  • Haluzik M, Sindelka G, Widimsky J Jr, Prazny M, Zelinka T, Skrha J. Serum leptin levels in patients with primary hyperaldosteronism before and after treatment: relationships to insulin sensitivity. J Hum Hypertens . 16(1):41-5 (2002)
  • Haluzik M, Svobodova J, Nedvidkova J, Papezova H, Kotrlikova E, Kabrt J. The relation of serum leptin levels and the degree of protein catabolism in patients with malnutrition.
  • Haluzikova D, Dostalova I, Kavalkova P, Roubicek T, Mraz M, Papezova H, Haluzik M. Serum concentrations of adipocyte fatty acid binding protein in patients with anorexia nervosa. Physiol Res. 2009;58 (4):577-81
  • Hancke K, Grubeck D, Hauser N, Kreienberg R, Weiss JM. Adipocyte fatty acid-binding protein as a novel prognostic factor in obese breast cancer patients. Breast Cancer Res Treat. 2010 Jan;119 (2):367-7
  • Hoareau L, Ravanan P, Gonthier MP, Delarue P, Goncalves J, Cesari M, Festy F, Roche R. Effect of PEA on LPS inflammatory action in human adipocytes. Cytokine . Jun;34(5-6):291-6 (2006)
  • Hoefle G, Saely CH, Risch L, Rein P, Koch L, Schmid F, Aczel S, Marte T, Langer P, Drexel H. Leptin, leptin soluble receptor and coronary atherosclerosis. Eur J Clin Invest . Aug;37(8):629-36 (2007)
  • Housova J, Wilczek H, Haluzik MM, Kremen J, Krizova J, Haluzik M. Adipocyte-derived hormones in heroin addicts: the influence of methadone maintenance treatment. Physiol Res . 54(1):73-8 (2005)
  • Hrebicek J, Janout V, Malincikova J, Horakova D, Cizek L. Detection of insulin resistance by simple quantitative insulin sensitivity check index QUICKI for epidemiological assessment and prevention. J Hum Hypertens . Jan;87(1):144-7 (2002)
  • Hulejova H, Levitova A, Kuklova M, Stochl J, Haluzik M, Pavelka K, Vencovsky J, Senolt L. No effect of physiotherapy on the serum levels of adipocytokines in patients with ankylosing spondylitis. Clin Rheumatol. 2011 May 28;
  • Jarkovska Z, Hodkova M, Sazamova M, Rosicka M, Dusilova-Sulkova S, Marek J, Justova V, Lacinova Z, Haluzik M, Haas T, Krsek M. Plasma levels of active and total ghrelin in renal failure: a relationship with GH/IGF-I axis. Growth Horm IGF Res . Dec;15(6):369-76 (2005)
  • Jean-Luc Gradidge P, ORCID:, Norris SA, Jaff NG, Crowther NJ. Metabolic and Body Composition Risk Factors Associated with Metabolic Syndrome in a Cohort of Women with a High Prevalence of Cardiometabolic Disease. PLoS One. 2016;11 (9):e0162247
  • Kalman S, Buyan N, Bayazit AK, Bideci A, Bakkaloglu S, ozkaya O, Soylemezoglu O. The role of leptin and soluble leptin receptor on the nutritional parameters in pediatric CPD patients. Nephrology Dialysis Transplantation . Volume 18 Supplement 4 June 2003
  • Kalousova M, Zima T, Popov P, Spacek P, Braun M, Soukupova J, Pelinkova K, Kientsch-Engel R. Advanced glycation end-products in patients with chronic alcohol misuse. Alcohol Alcohol . Jul-Aug;39(4):316-20 (2004)
  • Karapanagiotou EM, Tsochatzis EA, Dilana KD, Tourkantonis I, Gratsias I, Syrigos KN. The significance of leptin, adiponectin, and resistin serum levels in non-small cell lung cancer (NSCLC). Lung Cancer. 2008 Mar 12;
  • Koch A, Weiskirchen R, Zimmermann HW, Sanson E, Trautwein C, Tacke F. Relevance of serum leptin and leptin-receptor concentrations in critically ill patients. Mediators Inflamm. 2010;2010
  • Krizova J, Sulkova S, Bednarova V, Parizkova J, Kotrlikova E, Haluzik M. Soluble leptin receptor levels in patients with chronic renal failure. Physiol Res . 52(3):347-351 (2003)
  • Krsek M, Rosicka M, Haluzik M, Svobodova J, Kotrlikova E, Justova V, Lacinova Z, Jarkovska Z. Plasma ghrelin levels in patients with short bowel syndrome. Endocr Res . Feb-May;28(1-2):27-33 (2002)
  • Krsek M, Silha JV, Jezkova J, Hana V, Marek J, Weiss V, Stepan JJ, Murphy LJ. Adipokine levels in Cushing's syndrome; elevated resistin levels in female patients with Cushing's syndrome. Clin Endocrinol (Oxf) . Mar;60(3):350-7 (2004)
  • Kukla M, Zwirska-Korczala K, Gabriel A, Waluga M, Warakomska I, Szczygiel B, Berdowska A, Mazur W, Wozniak-Grygiel E, Kryczka W. Chemerin, vaspin and insulin resistance in chronic hepatitis C. J Viral Hepat. 2010 Sep;17 (9):661-7
  • Lamota L, Bermudez-Silva FJ, Marco EM, Llorente R, Gallego A, Rodriguez de Fonseca F, Viveros MP. Effects of adolescent nicotine and SR 147778 (Surinabant) administration on food intake, somatic growth and metabolic parameters in rats. Neuropharmacology. 2008 Jan;54 (1):194-205
  • Lee HJ, Jung H, Cho H, Lee K, Kwak HK, Hwang KT. Dietary Black Raspberry Seed Oil Ameliorates Inflammatory Activities in db/db Mice. Lipids. 2016 May 10;
  • Lichnovska R, Gwozdziewiczova S, Hrebicek J. Gender differences in factors influencing insulin resistance in elderly hyperlipemic non-diabetic subjects. Cardiovasc Diabetol . Oct 14;1(1):4 (2002)
  • Lin SY, Huang SC, Sheu WH. Circulating adiponectin concentrations were related to free thyroxine levels in thyroid cancer patients after thyroid hormone withdrawal. Metabolism. 2010 Feb;59 (2):195-9
  • Luque-Ramirez M, Martinez-Garcia MA, Montes-Nieto R, Fernandez-Duran E, Insenser M, Alpanes M, Escobar-Morreale HF. Sexual dimorphism in adipose tissue function as evidenced by circulating adipokine concentrations in the fasting state and after an oral glucose challenge. Hum Reprod. 2013 Jul;28 (7):1908-18
  • Maletinska L, Toma RS, Pirnik Z, Kiss A, Slaninova J, Haluzik M, Zelezna B. Effect of cholecystokinin on feeding is attenuated in monosodium glutamate obese mice. Regul Pept . Sep 11;136(1-3):58-63 (2006)
  • Malincikova J, Stejskal D, Hrebicek J. Serum leptin and leptin receptors in healthy prepubertal children: relations to insulin resistance and lipid parameters, body mass index (BMI), tumor necrosis factor alpha (TNF alpha), heart fatty acid binding protein (hFABP), and IgG anticardiolipin. Acta Univ Palacki Olomuc Fac Med . 143:51-7 (2000)
  • Mangge H, Freytag F, Almer G, Weghuber D, Bauer-Denk C, Fuchs D. Serum neopterin is not increased in obese juveniles. J Obes. 2011;2011:946795
  • Markova M, Haluzik M, Svobodova J, Rosicka M, Nedvidkova J, Haas T. Serum leptin levels in patients with sideropenic and pernicious anemia: the influence of anemia treatment. Physiol Res. 2000;49 (6):679-84
  • Mazur W, Kukla M, Logiewa-Bazger B, Beniowski M, Kwiatkowski J, Wagner G, Jurzak M, Berdowska A, Żwirska-Korczala K. Resistin, leptin and ghrelin serum levels among the patients with chronic hepatitis C. E&C Hepatology. 2010;6(3-4):17-24
  • Meier U, Gressner AM. Endocrine regulation of energy metabolism: review of pathobiochemical and clinical chemical aspects of leptin, ghrelin, adiponectin, and resistin. Clin Chem. 2004 Sep;50 (9):1511-25
  • Mente A, Razak F, Blankenberg S, Vuksan V, Davis AD, Miller R, Teo K, Gerstein H, Sharma AM, Yusuf S, Anand SS. Ethnic variation in adiponectin and leptin levels and their association with adiposity and insulin resistance. Diabetes Care. 2010 Jul;33 (7):1629-34
  • Mitchell SE, Nogueiras R, Morris A, Tovar S, Grant C, Cruickshank M, Rayner DV, Dieguez C, Williams LM. Leptin receptor gene expression and number in the brain are regulated by leptin level and nutritional status. J Physiol. 2009 Jul 15;587 (Pt 14):3573-85
  • Moro C, Klimcakova E, Lolmede K, Berlan M, Lafontan M, Stich V, Bouloumie A, Galitzky J, Arner P, Langin D. Atrial natriuretic peptide inhibits the production of adipokines and cytokines linked to inflammation and insulin resistance in human subcutaneous adipose tissue. Diabetologia . May;50(5):1038-47 (2007)
  • Ojanen T, Jalanko P, Kyröläinen H. Physical fitness, hormonal, and immunological responses during prolonged military field training. Physiol Rep. 2018;6(17):e13850.
  • Olszanecka-Glinianowicz M, Zahorska-Markiewicz B, Kocelak P, Janowska J, Semik-Grabarczyk E, Wikarek T, Gruszka W, Dabrowski P. Is chronic inflammation a possible cause of obesity-related depression?. Mediators Inflamm. 2009;2009:439107
  • Pamuk GE, Demir M, Harmandar F, Yesil Y, Turgut B, Vural O. Leptin and resistin levels in serum of patients with hematologic malignancies: correlation with clinical characteristics. Exp Oncol . Sep;28(3):241-4 (2006)
  • Paul G, Schaffler A, Neumeier M, Furst A, Bataillle F, Buechler C, Muller-Ladner U, Scholmerich J, Rogler G, Herfarth H. Profiling adipocytokine secretion from creeping fat in Crohn's disease. Inflamm Bowel Dis . Jun;12(6):471-7 (2006)
  • Petzel M, Stejskal D, Jedelsky L, Kadalova L, Safarcik K. The influence of estradiole and tibolone administration on leptin levels in women with surgically induced menopause. Biomed Pap Med Fac Univ Palack. 2008 Jun;152 (1):101-5
  • Pilz S, Horejsi R, Moller R, Almer G, Scharnagl H, Stojakovic T, Dimitrova R, Weihrauch G, Borkenstein M, Maerz W, Schauenstein K, Mangge H. Early atherosclerosis in obese juveniles is associated with low serum levels of adiponectin. J Clin Endocrinol Metab . Aug;90(8):4792-6 (2005)
  • Popa M, Stefanescu AM, Procopiuc C, Dumitrescu C. Serum Leptin and Leptin binding activity after ten days administration of rhGH (as IGF I generation test) in short children. Endocrine Care. 2007;vol. III (no. 2, p.):p. 161-168
  • Pourghassem Gargari B, Houjeghani S, Farzadi L, Houjeghani S, Safaeiyan A. Relationship between Serum Leptin, Ghrelin and Dietary Macronutrients in Women with Polycystic Ovary Syndrome. Int J Fertil Steril. 2015;9(3):313-21.
  • Puurunen VP, Lepojarvi ES, Piira OP, Hedberg P, Junttila MJ, Ukkola O, Huikuri HV. High plasma leptin levels are associated with impaired diastolic function in patients with coronary artery disease. Peptides. 2016 Aug 11;84:17-21
  • Ripolles Piquer B, Nazih H, Bourreille A, Segain JP, Huvelin JM, Galmiche JP, Bard JM. Altered lipid, apolipoprotein, and lipoprotein profiles in inflammatory bowel disease: consequences on the cholesterol efflux capacity of serum using Fu5AH cell system. Metabolism . Jul;55(7):980-8 (2006)
  • Risch L, Saely C, Hoefle G, Rein P, Langer P, Gouya G, Marte T, Aczel S, Drexel H. Relationship between glomerular filtration rate and the adipokines adiponectin, resistin and leptin in coronary patients with predominantly normal or mildly impaired renal function. Clin Chim Acta. 2007 Feb;376 (1-2):108-13
  • Rozmilowska I, Czyzewski D, Mazur B, Adamczyk-Sowa M. What is the role of adipokines in myasthenia gravis?. Ther Clin Risk Manag. 2018;14:1515-1525. Published 2018 Aug 28. doi:10.2147/TCRM.S163966
  • Rubino E, Vacca A, Govone F, Gai A, Boschi S, Zucca M, De Martino P, Gentile S, Pinessi L, Rainero I. Investigating the role of adipokines in chronic migraine. Cephalalgia. 2016 Aug 22;
  • Ruffingshofer D, Endemann M, Arbeiter K, Bidmon B, Mueller T, Herkner K, Aufricht C. Induction of heat shock protein 72 in mesothelial cells exposed to peritoneal dialysate effluent. Perit Dial Int. 2003 Jan-Feb;23 (1):74-7
  • Sainz N, Rodriguez A, Catalan V, Becerril S, Ramirez B, Gomez-Ambrosi J, Fruhbeck G. Leptin administration favors muscle mass accretion by decreasing FoxO3a and increasing PGC-1alpha in ob/ob mice. PLoS One. 2009;4 (9):e6808
  • Seidel M, King JA, Ritschel F, et al. Processing and regulation of negative emotions in anorexia nervosa: An fMRI study. Neuroimage Clin. 2017;18:1-8. Published 2017 Dec 24. doi:10.1016/j.nicl.2017.12.035
  • Semnani S, Roshandel G, Keshtkar A, Najafi L, Amiriani T, Farajollahi M, Moradi A, Joshaghani H. Serum leptin levels and irritable bowel syndrome: a new hypothesis. J Clin Gastroenterol. 2009 Oct;43 (9):826-30
  • Senolt L, Kuklova M, Cerezo LA, Hulejova H, Filkova M, Bosanska L, Pecha O, Pavelka K, Haluzik M, Vencovsky J. Adipokine profile is modulated in subcutaneous adipose tissue by TNFalpha inhibitors in patients with rheumatoid arthritis. Ann Rheum Dis. 2011 Nov;70 (11):2054-6
  • Schaffler A, Landfried K, Volk M, Furst A, Buchler C, Scholmerich J, Herfarth H. Potential of adipocytokines in predicting peripancreatic necrosis and severity in acute pancreatitis: pilot study. J Gastroenterol Hepatol. 2007 Mar;22 (3):326-34
  • Silha JV, Nyomba BL, Leslie WD, Murphy LJ. Ethnicity, insulin resistance, and inflammatory adipokines in women at high and low risk for vascular disease. Diabetes Care. 2007 Feb;30 (2):286-91
  • Stejskal D, Adamovska S, Bartek J, Jurakova R, Proskova J. Resistin - concentrations in persons with type 2 diabetes mellitus and in individuals with acute inflammatory disease. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub . Nov;147(1):63-9 (2003)
  • Stejskal D, Bartek J, Ruzicka V, Stejskal P, Jedelsky L, Oral I, Horalik D, Zurek M. Determination of leptin receptor in the serum and relations to laboratory and anthropological parameters in patients with atherosclerotic complications. Acta Univ Palacki Olomouc Fac Med . 142:89-92 (1999)
  • Stejskal D, Ruzicka V, Adamovska S, Jurakova R, Proskova J, Jedelsky L, Bartek J. Adiponectin concentrations as a criterion of metabolic control in persons with type 2 diabetes mellitus?. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub . Dec;147(2):167-72 (2003)
  • Stejskal D, Stejskal P, Ruzicka V, Jedelsky L, Horalik D, Kalina M, Bartek J. Leptinaemia in the Czech population. Vnitr Lek . Mar;45(3):139-47 (1999)
  • Szczepankiewicz D, Sobkowiak P, Narożna B, Wojsyk-Banaszak I, Bręborowicz A, Szczepankiewicz A. Leptin gene polymorphism affects leptin level in childhood asthma. World J Pediatr. 2018;14(6):601-606.
  • Teplan V, Schuck O, Stollova M, Vitko S. Obesity and hyperhomocysteinaemia after kidney transplantation. Nephrol Dial Transplant . Jul;18 Suppl 5:v71-3 (2003)
  • Trachta P, Dostalova I, Haluzikova D, Kasalicky M, Kavalkova P, Drapalova J, Urbanova M, Lacinova Z, Mraz M, Haluzik M. Laparoscopic sleeve gastrectomy ameliorates mRNA expression of inflammation-related genes in subcutaneous adipose tissue but not in peripheral monocytes of obese patients. Mol Cell Endocrinol. 2014 Mar 5;383 (1-2):96-102
  • Tsaroucha A, Daniil Z, Malli F, Georgoulias P, Minas M, Kostikas K, Bargiota A, Zintzaras E, Gourgoulianis KI. Leptin, adiponectin, and ghrelin levels in female patients with asthma during stable and exacerbation periods. J Asthma. 2013 Mar;50 (2):188-97
  • van Dielen FM, van 't Veer C, Buurman WA, Greve JW. Leptin and soluble leptin receptor levels in obese and weight-losing individuals. J Clin Endocrinol Metab. 2002 Apr;87 (4):1708-16
  • van Dielen FM, van't Veer C, Schols AM, Soeters PB, Buurman WA, Greve JW. Increased leptin concentrations correlate with increased concentrations of inflammatory markers in morbidly obese individuals. Int J Obes Relat Metab Disord . 25(12):1759-66 (2001)
  • Vitkova M, Klimcakova E, Kovacikova M, Valle C, Moro C, Polak J, Hanacek J, Capel F, Viguerie N, Richterova B, Bajzova M, Hejnova J, Stich V, Langin D. Plasma levels and adipose tissue messenger ribonucleic acid expression of retinol-binding protein 4 are reduced during calorie restriction in obese subjects but are not related to diet-induced changes in insulin sensitivity. J Clin Endocrinol Metab . Jun;92(6):2330-5 (2007)
  • Welt CK, Schneyer AL, Heist K, Mantzoros CS. Leptin and soluble leptin receptor in follicular fluid. J Assist Reprod Genet. Dec;20(12):495-501 (2003)
  • Wiecek M, Szymura J, Maciejczyk M, Kantorowicz M, Szygula Z. Acute Anaerobic Exercise Affects the Secretion of Asprosin, Irisin, and Other Cytokines - A Comparison Between Sexes. Front Physiol. 2018;9:1782. Published 2018 Dec 10. doi:10.3389/fphys.2018.01782
  • Wilson R, Willis J, Gearry RB, et al. SunGold Kiwifruit Supplementation of Individuals with Prediabetes Alters Gut Microbiota and Improves Vitamin C Status, Anthropometric and Clinical Markers. Nutrients. 2018;10(7):895. Published 2018 Jul 12. doi:10.3390/nu10070895
  • Wojcik K, Jablonowska E, Omulecka A, Piekarska A. Insulin resistance, adipokine profile and hepatic expression of SOCS-3 gene in chronic hepatitis C. World J Gastroenterol. 2014 Aug 14;20 (30):10449-56
  • Woo YC, Lee CH, Fong CH, Xu A, Tso AW, Cheung BM, Lam KS. Serum fibroblast growth factor 21 is a superior biomarker to other adipokines in predicting incident diabetes. Clin Endocrinol (Oxf). 2016 Sep 9;
  • Zarei S, Soltanghoraee H, Mohammadzadeh A, Arefi S, Zarnani AH, Idali. Serum Leptin Levels in Women with Immunological Recurrent Abortion. J Reprod Infertil. 2010;11(1);:47-52
Summary References (20)

References to Leptin

  • Auwerx J, Staels B. Leptin (Review article). The Lancet . 13, 737 (1998);
  • Blum WF, Englaro P, Hanitsch S, Juul A, Hertel NT, Muller J, Skakkebaek NE, Heiman ML, Birkett M, Attanasio AM, Kiess W, Rascher W. Plasma leptin levels in healthy children and adolescents: dependence on body mass index, body fat mass, gender, pubertal stage, and testosterone. J Clin Endocrinol Metab. 1997 Sep;82 (9):2904-10
  • Chehab FF, Mounzih K, Lu R, Lim ME. Early onset of reproductive function in normal female mice treated with leptin. Science. 1997 Jan 3;275 (5296):88-90
  • Clement K, Vaisse C, Lahlou N, Cabrol S, Pelloux V, Cassuto D, Gourmelen M, Dina C, Chambaz J, Lacorte JM, Basdevant A, Bougneres P, Lebouc Y, Froguel P, Guy-Grand B. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature. 1998 Mar 26;392 (6674):398-401
  • Cohen B, Novick D, Rubinstein M. Modulation of insulin activities by leptin. Science. 1996 Nov 15;274 (5290):1185-8
  • Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, Ohannesian JP, Marco CC, McKee LJ, Bauer TL, et al. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med. 1996 Feb 1;334 (5):292-5
  • Friedman JM, Halaas JL. Leptin and the regulation of body weight in mammals. Nature. 1998 Oct 22;395 (6704):763-70
  • Halaas JL, Gajiwala KS, Maffei M, Cohen SL, Chait BT, Rabinowitz D, Lallone RL, Burley SK, Friedman JM. Weight-reducing effects of the plasma protein encoded by the obese gene. Science. 1995 Jul 28;269 (5223):543-6
  • Harigaya A, Nagashima K, Nako Y, Morikawa A. Relationship between concentration of serum leptin and fetal growth. J Clin Endocrinol Metab. 1997 Oct;82 (10):3281-4
  • Lonnqvist F, Arner P, Nordfors L, Schalling M. Overexpression of the obese (ob) gene in adipose tissue of human obese subjects. Nat Med. 1995 Sep;1 (9):950-3
  • Maffei M, Halaas J, Ravussin E, Pratley RE, Lee GH, Zhang Y, Fei H, Kim S, Lallone R, Ranganathan S, et al. Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med. 1995 Nov;1 (11):1155-61
  • Montague CT, Farooqi IS, Whitehead JP, Soos MA, Rau H, Wareham NJ, Sewter CP, Digby JE, Mohammed SN, Hurst JA, Cheetham CH, Earley AR, Barnett AH, Prins JB, O'Rahilly S. Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature. 1997 Jun 26;387 (6636):903-8
  • Pelleymounter MA, Cullen MJ, Baker MB, Hecht R, Winters D, Boone T, Collins F. Effects of the obese gene product on body weight regulation in ob/ob mice. Science. 1995 Jul 28;269 (5223):540-3
  • Ricci MR, Lee MJ, Russell CD, Wang Y, Sullivan S, Schneider SH, Brolin RE, Fried SK. Isoproterenol decreases leptin release from rat and human adipose tissue through posttranscriptional mechanisms. Am J Physiol Endocrinol Metab. 2005 Apr;288 (4):E798-804
  • Schubring C, Prohaska F, Prohaska A, Englaro P, Blum W, Siebler T, Kratzsch J, Kiess W. Leptin concentrations in maternal serum and amniotic fluid during the second trimenon: differential relation to fetal gender and maternal morphometry. Eur J Obstet Gynecol Reprod Bi. 1999 Oct;86 (2):151-7
  • Spiegelman BM, Flier JS. Adipogenesis and obesity: rounding out the big picture. Cell. 1996 Nov 1;87 (3):377-89
  • Tartaglia LA. The leptin receptor. J Biol Chem. 1997 Mar 7;272 (10):6093-6
  • Tritos NA, Mantzoros CS. Leptin: its role in obesity and beyond. Diabetologia. 1997 Dec;40 (12):1371-9
  • Zhang F, Basinski MB, Beals JM, Briggs SL, Churgay LM, Clawson DK, DiMarchi RD, Furman TC, Hale JE, Hsiung HM, Schoner BE, Smith DP, Zhang XY, Wery JP, Schevitz RW. Crystal structure of the obese protein leptin-E100. Nature. 1997 May 8;387 (6629):206-9
  • Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature. 1994 Dec 1;372 (6505):425-32
Related Products Docs