Select country change
Shopping cart (0 , 0,00 ) Menu Search
Manufactured by BioVendor

Leptin Human ELISA, Clinical Range

  • Regulatory status:RUO
  • Type:Sandwich ELISA, HRP-labelled antibody
  • Other names:Obesity factor, Obese protein, LEP, OB, OBS
  • Species:Human
Please select your region to see available products and prices.
Cat. No. Size Price


RD191001100 96 wells (1 kit)
PubMed Product Details
Technical Data

Type

Sandwich ELISA, HRP-labelled antibody

Applications

Serum, Plasma-EDTA, Plasma-Heparin, Plasma-Citrate

Sample Requirements

35 µl/well

Shipping

At ambient temperature. Upon receipt, store the product at the temperature recommended below.

Storage/Expiration

Store the kit at 2–8°C. Under these conditions, the kit is stable until the expiration date (see label on the box).

Calibration Curve

Calibration Range

1-50 ng/ml

Limit of Detection

0.2 ng/ml

Intra-assay (Within-Run)

n=8, CV = 5.9%

Inter-assay (Run-to-Run)

n=6, CV = 5.6%

Spiking Recovery

92.1%

Dilution Linearity

100.8%

Crossreactivity

  • bovine Non-detectable
  • cat Non-detectable
  • dog Non-detectable
  • goat Non-detectable
  • hamster Non-detectable
  • horse Non-detectable
  • monkey Non-detectable
  • mouse Non-detectable
  • pig Non-detectable
  • rabbit Non-detectable
  • rat Non-detectable
  • sheep Non-detectable
  • chicken Not tested
  • human Yes
Summary

Features

  • European Union: for in vitro diagnostic use
  • Rest of the world: for research use only!
  • The total assay time is less than 2.5 hours
  • The kit measures total leptin
  • Assay format is 96 wells
  • Quality Controls are human serum based
  • Standards are recombinant protein based
  • Components of the kit are provided ready to use, concentrated or lyophilized

Research topic

Diabetology - Other Relevant Products, Energy metabolism and body weight regulation, Reproduction

Summary

Leptin, the product of the ob (obese) gene, is a single-chain 16 kDa protein consisting of 146
amino acid residues. Leptin is produced mainly in the adipose tissue, and is considered to play
an important role in appetite control, fat metabolism and body weight regulation. It targets the
central nervous system, particularly hypothalamus, affecting food intake. The primary effect of
leptin appears to be mediated by leptin receptors expressed mainly in the hypothalamus. In
humans, leptin levels correlate with body mass index (BMI) and percentage body fat, and are
elevated even in obese individuals. Leptin has a dual action; it decreases the appetite and
increases energy consumption, causing more fat to be burned. Leptin is secreted in circadian
fashion with nocturnal rise in both lean and obese patients.

Mutations of the ob gene resulting in leptin deficiency are the cause of obesity in the ob/ob
mice. Endogeneous leptin can normalize their body weight. In contrast, high levels of leptin in
obese human subjects point to an insensitivity to endogeneous leptin.
Other factors in addition to the amount of body fat appear to regulate leptin action: insulin,
glucocorticoids, catecholamines and sex hormones. Studies have shown that leptin may be
linked to reproductive function.

Product References (110)

References

  • Adam JA, Menheere PP, van Dielen FM, Soeters PB, Buurman WA, Greve JW.Decreased plasma orexin-A levels in obese individuals. Int J Obes Relat MetabDisord. 2002 Feb;26(2):274-6. PubMed PMID: 11850761. See more on PubMed
  • Adamska-Patruno E, Ostrowska L, Goscik J, Pietraszewska B, Kretowski A, GorskaM. The relationship between the leptin/ghrelin ratio and meals with variousmacronutrient contents in men with different nutritional status: a randomizedcrossover study. Nutr J. 2018 Dec 28;17(1):118. doi: 10.1186/s12937-018-0427-x.PubMed PMID: 30593267; PubMed Central PMCID: PMC6309055. See more on PubMed
  • Aeberli I, Beljean N, Lehmann R, I'Allemand D, Spinas GA, Zimmermann MB. Theincrease of fatty acid-binding protein aP2 in overweight and obese children:interactions with dietary fat and impact on measures of subclinical inflammation.Int J Obes (Lond). 2008 Oct;32(10):1513-20. doi: 10.1038/ijo.2008.128. Epub 2008 Aug 5. PubMed PMID: 18679408. See more on PubMed
  • Arnold T, Brandlhofer S, Vrtikapa K, Stangl H, Hermann M, Zwiauer K, Mangge H,Karwautz A, Huemer J, Koller D, Schneider WJ, Strobl W. Effect of obesity onplasma clusterin, [corrected] a proposed modulator of leptin action. Pediatr Res.2011 Mar;69(3):237-42. doi: 10.1203/PDR.0b013e31820930cb. Erratum in: PediatrRes. 2011 Apr;69(4):358. PubMed PMID: 21135756. See more on PubMed
  • Aydin HI, Yozgat Y, Demirkaya E, Olgun A, Okutan V, Lenk MK, Ozcan O.Correlation between vascular endothelial growth factor and leptin in childrenwith cyanotic congenital heart disease. Turk J Pediatr. 2007 Oct-Dec;49(4):360-4.PubMed PMID: 18246735. See more on PubMed
  • Azzoni L, Crowther NJ, Firnhaber C, Foulkes AS, Yin X, Glencross D, Gross R,Kaplan MD, Papasavvas E, Schulze D, Stevens W, van der Merwe T, Waisberg R, SanneI, Montaner LJ. Association between HIV replication and serum leptin levels: anobservational study of a cohort of HIV-1-infected South African women. J Int AIDSSoc. 2010 Sep 7;13:33. doi: 10.1186/1758-2652-13-33. PubMed PMID: 20822522;PubMed Central PMCID: PMC2941743. See more on PubMed
  • Baeza I, Vigo L, de la Serna E, Calvo-Escalona R, Merchán-Naranjo J,Rodríguez-Latorre P, Arango C, Castro-Fornieles J. The effects of antipsychotics on weight gain, weight-related hormones and homocysteine in children andadolescents: a 1-year follow-up study. Eur Child Adolesc Psychiatry. 2017Jan;26(1):35-46. doi: 10.1007/s00787-016-0866-x. Epub 2016 May 21. PubMed PMID:27209421. See more on PubMed
  • Bahijri SM, Ajabnoor G, Hegazy GA, Alsheikh L, Moumena MZ, Bashanfar BM,Alzahrani AH. Supplementation with Oligonol, Prevents Weight Gain and ImprovesLipid Profile in Overweight and Obese Saudi Females. Curr Nutr Food Sci. 2018Apr;14(2):164-170. doi: 10.2174/1573401313666170609101408. PubMed PMID: 29853817;PubMed Central PMCID: PMC5907059. See more on PubMed
  • Stejskal D, Bartek J, Růzicka V, Stejskal P, Jedelský L, Oral I, Horalík D,Zurek M. Determination of leptin receptor in the serum and relations tolaboratory and anthropological parameters in patients with atheroscleroticcomplications. Acta Univ Palacki Olomuc Fac Med. 1999;142:89-92. PubMed PMID:10743733. See more on PubMed
  • Bronsky J, Karpísek M, Bronská E, Pechová M, Jancíková B, Kotolová H, StejskalD, Prusa R, Nevoral J. Adiponectin, adipocyte fatty acid binding protein, andepidermal fatty acid binding protein: proteins newly identified in human breastmilk. Clin Chem. 2006 Sep;52(9):1763-70. Epub 2006 Jul 27. PubMed PMID: 16873294. See more on PubMed
  • Bronsky J, Mitrova K, Karpisek M, Mazoch J, Durilova M, Fisarkova B, Stechova K, Prusa R, Nevoral J. Adiponectin, AFABP, and leptin in human breast milk during12 months of lactation. J Pediatr Gastroenterol Nutr. 2011 Apr;52(4):474-7. doi: 10.1097/MPG.0b013e3182062fcc. PubMed PMID: 21407103. See more on PubMed
  • Bužga M, Evžen M, Pavel K, Tomáš K, Vladislava Z, Pavel Z, Svagera Z. Effects of the intragastric balloon MedSil on weight loss, fat tissue, lipid metabolism, and hormones involved in energy balance. Obes Surg. 2014 Jun;24(6):909-15. doi:10.1007/s11695-014-1191-4. PubMed PMID: 24488758; PubMed Central PMCID:PMC4022986. See more on PubMed
  • Cagnacci A, Arangino S, Caretto S, Mazza V, Volpe A. Sexual dimorphism in the levels of amniotic fluid leptin in pregnancies at 16 weeks of gestation: relationto fetal growth. Eur J Obstet Gynecol Reprod Biol. 2006 Jan 1;124(1):53-7. Epub2005 Jul 26. PubMed PMID: 16051417. See more on PubMed
  • Cambuli VM, Musiu MC, Incani M, Paderi M, Serpe R, Marras V, Cossu E, Cavallo MG, Mariotti S, Loche S, Baroni MG. Assessment of adiponectin and leptin asbiomarkers of positive metabolic outcomes after lifestyle intervention inoverweight and obese children. J Clin Endocrinol Metab. 2008 Aug;93(8):3051-7.doi: 10.1210/jc.2008-0476. Epub 2008 May 20. PubMed PMID: 18492759. See more on PubMed
  • Capel F, Klimcáková E, Viguerie N, Roussel B, Vítková M, Kováciková M, PolákJ, Kovácová Z, Galitzky J, Maoret JJ, Hanácek J, Pers TH, Bouloumié A, Stich V,Langin D. Macrophages and adipocytes in human obesity: adipose tissue geneexpression and insulin sensitivity during calorie restriction and weightstabilization. Diabetes. 2009 Jul;58(7):1558-67. doi: 10.2337/db09-0033. Epub2009 Apr 28. PubMed PMID: 19401422; PubMed Central PMCID: PMC2699855. See more on PubMed
  • Cinkajzlova A, Lacinova Z, Klouckova J, Kavalkova P, Trachta P, Kosak M,Haluzikova D, Papezova H, Mraz M, Haluzík M. Angiopoietin-like protein 6 inpatients with obesity, type 2 diabetes mellitus, and anorexia nervosa: Theinfluence of very low-calorie diet, bariatric surgery, and partialrealimentation. Endocr Res. 2017 Feb;42(1):22-30. doi:10.3109/07435800.2016.1169544. Epub 2016 May 2. PubMed PMID: 27135654. See more on PubMed
  • Cinkajzlová A, Mráz M, Lacinová Z, Kloučková J, Kaválková P, Kratochvílová H, Trachta P, Křížová J, Haluzíková D, Škrha J, Papežová H, Haluzík M.Angiopoietin-like protein 3 and 4 in obesity, type 2 diabetes mellitus, andmalnutrition: the effect of weight reduction and realimentation. Nutr Diabetes.2018 Apr 25;8(1):21. doi: 10.1038/s41387-018-0032-2. PubMed PMID: 29695708;PubMed Central PMCID: PMC5916880. See more on PubMed
  • Creutzberg EC, Wouters EF, Vanderhoven-Augustin IM, Dentener MA, Schols AM.Disturbances in leptin metabolism are related to energy imbalance during acuteexacerbations of chronic obstructive pulmonary disease. Am J Respir Crit CareMed. 2000 Oct;162(4 Pt 1):1239-45. PubMed PMID: 11029324. See more on PubMed
  • Dayer D, Nikbakht R, Kadkhodai Elyaderani M. Comparison of leptinconcentrations between infertile women with polycystic ovary syndrome and fertilewomen. Iran J Reprod Med. 2013 Dec;11(12):1033-4. PubMed PMID: 24639732; PubMedCentral PMCID: PMC3941400. See more on PubMed
  • Díez ML, Santolaria F, Tejera A, Alemán MR, González-Reimers E, Milena A, dela Vega MJ, Martínez-Riera A. Serum leptin levels in community acquired pneumonia(CAP) are related to nutritional status and not to acute phase reaction.Cytokine. 2008 May;42(2):156-160. doi: 10.1016/j.cyto.2008.02.013. Epub 2008 Apr 18. PubMed PMID: 18396058. See more on PubMed
  • Ding Q, Mracek T, Gonzalez-Muniesa P, Kos K, Wilding J, Trayhurn P, Bing C.Identification of macrophage inhibitory cytokine-1 in adipose tissue and itssecretion as an adipokine by human adipocytes. Endocrinology. 2009Apr;150(4):1688-96. doi: 10.1210/en.2008-0952. Epub 2008 Dec 12. PubMed PMID:19074584. See more on PubMed
  • Disse E, Graeppi-Dulac J, Joncour-Mills G, Dupuis O, Thivolet C. Heterogeneityof pregnancy outcomes and risk of LGA neonates in Caucasian females according to IADPSG criteria for gestational diabetes mellitus. Diabetes Metab. 2013Apr;39(2):132-8. doi: 10.1016/j.diabet.2012.09.006. Epub 2012 Nov 22. PubMedPMID: 23182459. See more on PubMed
  • Dolinková M, Dostálová I, Lacinová Z, Michalský D, Haluzíková D, Mráz M,Kasalický M, Haluzík M. The endocrine profile of subcutaneous and visceraladipose tissue of obese patients. Mol Cell Endocrinol. 2008 Sep10;291(1-2):63-70. doi: 10.1016/j.mce.2008.05.001. Epub 2008 May 9. PubMed PMID: 18565643. See more on PubMed
  • Dostálová I, Kaválková P, Haluzíková D, Lacinová Z, Mráz M, Papezová H,Haluzík M. Plasma concentrations of fibroblast growth factors 19 and 21 inpatients with anorexia nervosa. J Clin Endocrinol Metab. 2008 Sep;93(9):3627-32. doi: 10.1210/jc.2008-0746. Epub 2008 Jun 17. PubMed PMID: 18559909. See more on PubMed
  • Dostálová I, Kaválková P, Papežová H, Domluvilová D, Zikán V, Haluzík M.Association of macrophage inhibitory cytokine-1 with nutritional status, bodycomposition and bone mineral density in patients with anorexia nervosa: theinfluence of partial realimentation. Nutr Metab (Lond). 2010 Apr 23;7:34. doi:10.1186/1743-7075-7-34. PubMed PMID: 20416056; PubMed Central PMCID: PMC2875215. See more on PubMed
  • Dumon C, Diabira D, Chudotvorova I, Bader F, Sahin S, Zhang J, Porcher C,Wayman G, Medina I, Gaiarsa JL. The adipocyte hormone leptin sets the emergenceof hippocampal inhibition in mice. Elife. 2018 Aug 14;7. pii: e36726. doi:10.7554/eLife.36726. PubMed PMID: 30106375; PubMed Central PMCID: PMC6112852. See more on PubMed
  • Durovcová V, Marek J, Hána V, Matoulek M, Zikán V, Haluzíková D, Kaválková P, Lacinová Z, Kršek M, Haluzík M. Plasma concentrations of adipocyte fatty acidbinding protein in patients with Cushing's syndrome. Physiol Res.2010;59(6):963-71. Epub 2010 Jun 9. PubMed PMID: 20533865. See more on PubMed
  • Elie AGIM, Bloksgaard M, Sun WY, Yang K, Man AWC, Xu A, Irmukhamedov A, Riber LP, Wang Y, De Mey JGR. Local enrichment of fatty acid-binding protein 4 in thepericardial cavity of cardiovascular disease patients. PLoS One. 2018 Nov5;13(11):e0206802. doi: 10.1371/journal.pone.0206802. eCollection 2018. PubMedPMID: 30395653; PubMed Central PMCID: PMC6218069. See more on PubMed
  • Fernández-Rodríguez CM, López-Serrano P, Alonso S, Gutiérrez ML, Lledó JL,Pérez-Calle JL, Temiño R, Cacho G, Nevado M, Casas ML, Gasalla JM, Bonet B.Long-term reversal of hypocholesterolaemia in patients with chronic hepatitis Cis related to sustained viral response and viral genotype. Aliment PharmacolTher. 2006 Aug 1;24(3):507-12. PubMed PMID: 16886916. See more on PubMed
  • Florentin M, Liberopoulos EN, Tellis CC, Derdemezis CS, Elisaf M, Tselepis A. Effects of rimonabant, as monotherapy and in combination with fenofibrate orezetimibe, on plasma adipokine levels: a pilot study. Angiology. 2010May;61(4):365-71. doi: 10.1177/0003319709352488. Epub 2009 Nov 18. PubMed PMID:19926622. See more on PubMed
  • Fryczkowski M, Bułdak RJ, Hejmo T, Kukla M, Żwirska-Korczala K. CirculatingLevels of Omentin, Leptin, VEGF, and HGF and Their Clinical Relevance with PSAMarker in Prostate Cancer. Dis Markers. 2018 Aug 16;2018:3852401. doi:10.1155/2018/3852401. eCollection 2018. PubMed PMID: 30186533; PubMed CentralPMCID: PMC6116468. See more on PubMed
  • Giapros V, Evagelidou E, Challa A, Kiortsis D, Drougia A, Andronikou S. Serum adiponectin and leptin levels and insulin resistance in children born large forgestational age are affected by the degree of overweight. Clin Endocrinol (Oxf). 2007 Mar;66(3):353-9. PubMed PMID: 17302868. See more on PubMed
  • Gilbert T, Roche S, Blond E, Bar JY, Drai J, Cuerq C, Haution-Bitker M,Ecochard R, Bonnefoy M. Association between Peripheral Leptin and AdiponectinLevels and Cognitive Decline in Patients with Neurocognitive Disorders ≥65 Years.J Alzheimers Dis. 2018;66(3):1255-1264. doi: 10.3233/JAD-180533. PubMed PMID:30400097; PubMed Central PMCID: PMC6294588. See more on PubMed
  • Haluzík M, Fiedler J, Nedvídková J, Ceska R. Serum leptin levels in patientswith hyperlipidemias. Nutrition. 2000 Jun;16(6):429-33. PubMed PMID: 10869898. See more on PubMed
  • Haluzik M, Markova M, Slaby JJ, Jiskra J, Krizova J, Hass T. The changes ofserum leptin and soluble leptin receptor levels in patients undergoingmobilization of peripheral blood stem cells before autologous stem cellstransplantation. Endocr Res. 2002 Aug;28(3):189-97. PubMed PMID: 12489568. See more on PubMed
  • Haluzík M, Matoulek M, Svacina S, Hilgertová J, Haas T. The influence ofshort-term fasting on serum leptin levels, and selected hormonal and metabolicparameters in morbidly obese and lean females. Endocr Res. 2001Feb-May;27(1-2):251-60. PubMed PMID: 11428717. See more on PubMed
  • Haluzík M, Sindelka G, Widimský J Jr, Prázný M, Zelinka T, Skrha J. Serumleptin levels in patients with primary hyperaldosteronism before and aftertreatment: relationships to insulin sensitivity. J Hum Hypertens. 2002Jan;16(1):41-5. PubMed PMID: 11840228. See more on PubMed
  • Haluzíková D, Dostálová I, Kaválková P, Roubícek T, Mráz M, Papezová H,Haluzík M. Serum concentrations of adipocyte fatty acid binding protein inpatients with anorexia nervosa. Physiol Res. 2009;58(4):577-81. Epub 2008 Jul 25.PubMed PMID: 18657008. See more on PubMed
  • Hancke K, Grubeck D, Hauser N, Kreienberg R, Weiss JM. Adipocyte fattyacid-binding protein as a novel prognostic factor in obese breast cancerpatients. Breast Cancer Res Treat. 2010 Jan;119(2):367-7. doi:10.1007/s10549-009-0577-9. PubMed PMID: 19842034. See more on PubMed
  • Hoareau L, Ravanan P, Gonthier MP, Delarue P, Gonçalves J, Césari M, Festy F, Roche R. Effect of PEA on LPS inflammatory action in human adipocytes. Cytokine. 2006 Jun;34(5-6):291-6. Epub 2006 Aug 1. PubMed PMID: 16884908. See more on PubMed
  • Hoefle G, Saely CH, Risch L, Rein P, Koch L, Schmid F, Aczél S, Marte T,Langer P, Drexel H. Leptin, leptin soluble receptor and coronary atherosclerosis.Eur J Clin Invest. 2007 Aug;37(8):629-36. PubMed PMID: 17635573. See more on PubMed
  • Housová J, Wilczek H, Haluzík MM, Kremen J, Krízová J, Haluzík M.Adipocyte-derived hormones in heroin addicts: the influence of methadonemaintenance treatment. Physiol Res. 2005;54(1):73-8. PubMed PMID: 15717844. See more on PubMed
  • Hrebícek J, Janout V, Malincíková J, Horáková D, Cízek L. Detection of insulinresistance by simple quantitative insulin sensitivity check index QUICKI forepidemiological assessment and prevention. J Clin Endocrinol Metab. 2002Jan;87(1):144-7. PubMed PMID: 11788638. See more on PubMed
  • Hulejová H, Levitová A, Kuklová M, Stochl J, Haluzík M, Pavelka K, VencovskýJ, Senolt L. No effect of physiotherapy on the serum levels of adipocytokines in patients with ankylosing spondylitis. Clin Rheumatol. 2012 Jan;31(1):67-71. doi: 10.1007/s10067-011-1773-7. Epub 2011 May 28. PubMed PMID: 21618078. See more on PubMed
  • Jarkovská Z, Hodková M, Sazamová M, Rosická M, Dusilová-Sulková S, Marek J,Justová V, Lacinová Z, Haluzík M, Haas T, Krsek M. Plasma levels of active andtotal ghrelin in renal failure: a relationship with GH/IGF-I axis. Growth HormIGF Res. 2005 Dec;15(6):369-76. Epub 2005 Sep 28. PubMed PMID: 16198134. See more on PubMed
  • Jean-Luc Gradidge P, Norris SA, Jaff NG, Crowther NJ. Metabolic and BodyComposition Risk Factors Associated with Metabolic Syndrome in a Cohort of Women with a High Prevalence of Cardiometabolic Disease. PLoS One. 2016 Sep2;11(9):e0162247. doi: 10.1371/journal.pone.0162247. eCollection 2016. Erratumin: PLoS One. 2016 Oct 17;11(10 ):e0165215. PubMed PMID: 27589387; PubMed CentralPMCID: PMC5010252. See more on PubMed
  • Kalousová M, Zima T, Popov P, Spacek P, Braun M, Soukupová J, Pelinkova K,Kientsch-Engel R. Advanced glycation end-products in patients with chronicalcohol misuse. Alcohol Alcohol. 2004 Jul-Aug;39(4):316-20. PubMed PMID:15208163. See more on PubMed
  • Karapanagiotou EM, Tsochatzis EA, Dilana KD, Tourkantonis I, Gratsias I,Syrigos KN. The significance of leptin, adiponectin, and resistin serum levels innon-small cell lung cancer (NSCLC). Lung Cancer. 2008 Sep;61(3):391-7. doi:10.1016/j.lungcan.2008.01.018. Epub 2008 Mar 14. PubMed PMID: 18342391. See more on PubMed
  • Koch A, Weiskirchen R, Zimmermann HW, Sanson E, Trautwein C, Tacke F.Relevance of serum leptin and leptin-receptor concentrations in critically illpatients. Mediators Inflamm. 2010;2010. pii: 473540. doi: 10.1155/2010/473540.Epub 2010 Sep 7. PubMed PMID: 20871818; PubMed Central PMCID: PMC2943118. See more on PubMed
  • Krízová J, Sulková S, Bednárová V, Parízková J, Kotrlíková E, Haluzík M.Soluble leptin receptor levels in patients with chronic renal failure. PhysiolRes. 2003;52(3):347-51. PubMed PMID: 12790767. See more on PubMed
  • Krsek M, Rosická M, Haluzík M, Svobodová J, Kotrlíková E, Justová V, Lacinová Z, Jarkovská Z. Plasma ghrelin levels in patients with short bowel syndrome.Endocr Res. 2002 Feb-May;28(1-2):27-33. PubMed PMID: 12108787. See more on PubMed
  • Krsek M, Silha JV, Jezková J, Hána V, Marek J, Weiss V, Stepán JJ, Murphy LJ. Adipokine levels in Cushing's syndrome; elevated resistin levels in femalepatients with Cushing's syndrome. Clin Endocrinol (Oxf). 2004 Mar;60(3):350-7.PubMed PMID: 15009001. See more on PubMed
  • Kukla M, Zwirska-Korczala K, Gabriel A, Waluga M, Warakomska I, Szczygiel B,Berdowska A, Mazur W, Wozniak-Grygiel E, Kryczka W. Chemerin, vaspin and insulin resistance in chronic hepatitis C. J Viral Hepat. 2010 Sep;17(9):661-7. doi:10.1111/j.1365-2893.2009.01224.x. Epub 2009 Nov 11. PubMed PMID: 20002564. See more on PubMed
  • Lamota L, Bermudez-Silva FJ, Marco EM, Llorente R, Gallego A, Rodríguez deFonseca F, Viveros MP. Effects of adolescent nicotine and SR 147778 (Surinabant) administration on food intake, somatic growth and metabolic parameters in rats.Neuropharmacology. 2008 Jan;54(1):194-205. Epub 2007 Jul 19. PubMed PMID:17720206. See more on PubMed
  • Lee HJ, Jung H, Cho H, Lee K, Kwak HK, Hwang KT. Dietary Black Raspberry Seed Oil Ameliorates Inflammatory Activities in db/db Mice. Lipids. 2016Jun;51(6):715-27. doi: 10.1007/s11745-016-4159-4. Epub 2016 May 10. PubMed PMID: 27165261. See more on PubMed
  • Lichnovská R, Gwozdziewiczová S, Hrebícek J. Gender differences in factorsinfluencing insulin resistance in elderly hyperlipemic non-diabetic subjects.Cardiovasc Diabetol. 2002 Oct 14;1:4. PubMed PMID: 12423554; PubMed CentralPMCID: PMC140144. See more on PubMed
  • Lin SY, Huang SC, Sheu WH. Circulating adiponectin concentrations were relatedto free thyroxine levels in thyroid cancer patients after thyroid hormonewithdrawal. Metabolism. 2010 Feb;59(2):195-9. doi: 10.1016/j.metabol.2009.06.032.Epub 2009 Sep 17. PubMed PMID: 19765779. See more on PubMed
  • Luque-Ramírez M, Martínez-García MÁ, Montes-Nieto R, Fernández-Durán E,Insenser M, Alpañés M, Escobar-Morreale HF. Sexual dimorphism in adipose tissuefunction as evidenced by circulating adipokine concentrations in the fastingstate and after an oral glucose challenge. Hum Reprod. 2013 Jul;28(7):1908-18.doi: 10.1093/humrep/det097. Epub 2013 Apr 4. PubMed PMID: 23559188. See more on PubMed
  • Maletínská L, Toma RS, Pirnik Z, Kiss A, Slaninová J, Haluzík M, Zelezná B.Effect of cholecystokinin on feeding is attenuated in monosodium glutamate obese mice. Regul Pept. 2006 Sep 11;136(1-3):58-63. Epub 2006 Jun 19. PubMed PMID:16782213. See more on PubMed
  • Malincíková J, Stejskal D, Hrebícek J. Serum leptin and leptin receptors inhealthy prepubertal children: relations to insulin resistance and lipidparameters, body mass index (BMI), tumor necrosis factor alpha (TNF alpha), heartfatty acid binding protein (hFABP), and IgG anticardiolipin (ACL-IgG). Acta Univ Palacki Olomuc Fac Med. 2000;143:51-7. PubMed PMID: 11144119. See more on PubMed
  • Mangge H, Freytag F, Almer G, Weghuber D, Bauer-Denk C, Fuchs D. Serumneopterin is not increased in obese juveniles. J Obes. 2011;2011:946795. doi:10.1155/2011/946795. Epub 2011 Jan 12. PubMed PMID: 21274279; PubMed CentralPMCID: PMC3025381. See more on PubMed
  • Marková M, Haluzík M, Svobodová J, Rosická M, Nedvídková J, Haas T. Serumleptin levels in patients with sideropenic and pernicious anemia: the influenceof anemia treatment. Physiol Res. 2000;49(6):679-84. PubMed PMID: 11252534. See more on PubMed
  • Meier U, Gressner AM. Endocrine regulation of energy metabolism: review ofpathobiochemical and clinical chemical aspects of leptin, ghrelin, adiponectin,and resistin. Clin Chem. 2004 Sep;50(9):1511-25. Epub 2004 Jul 20. Review. PubMedPMID: 15265818. See more on PubMed
  • Mente A, Razak F, Blankenberg S, Vuksan V, Davis AD, Miller R, Teo K, GersteinH, Sharma AM, Yusuf S, Anand SS; Study of the Health Assessment And RiskEvaluation; Study of the Health Assessment And Risk Evaluation in AboriginalPeoples Investigators. Ethnic variation in adiponectin and leptin levels andtheir association with adiposity and insulin resistance. Diabetes Care. 2010Jul;33(7):1629-34. doi: 10.2337/dc09-1392. Epub 2010 Apr 22. PubMed PMID:20413520; PubMed Central PMCID: PMC2890372. See more on PubMed
  • Mitchell SE, Nogueiras R, Morris A, Tovar S, Grant C, Cruickshank M, RaynerDV, Dieguez C, Williams LM. Leptin receptor gene expression and number in thebrain are regulated by leptin level and nutritional status. J Physiol. 2009 Jul15;587(Pt 14):3573-85. doi: 10.1113/jphysiol.2009.173328. Epub 2009 Jun 2. PubMedPMID: 19491239; PubMed Central PMCID: PMC2742282. See more on PubMed
  • Moro C, Klimcakova E, Lolmède K, Berlan M, Lafontan M, Stich V, Bouloumié A,Galitzky J, Arner P, Langin D. Atrial natriuretic peptide inhibits the productionof adipokines and cytokines linked to inflammation and insulin resistance inhuman subcutaneous adipose tissue. Diabetologia. 2007 May;50(5):1038-47. Epub2007 Feb 23. PubMed PMID: 17318625. See more on PubMed
  • Ojanen T, Jalanko P, Kyröläinen H. Physical fitness, hormonal, andimmunological responses during prolonged military field training. Physiol Rep.2018 Sep;6(17):e13850. doi: 10.14814/phy2.13850. PubMed PMID: 30187684; PubMedCentral PMCID: PMC6125608. See more on PubMed
  • Olszanecka-Glinianowicz M, Zahorska-Markiewicz B, Kocełak P, Janowska J,Semik-Grabarczyk E, Wikarek T, Gruszka W, Dabrowski P. Is chronic inflammation a possible cause of obesity-related depression? Mediators Inflamm.2009;2009:439107. doi: 10.1155/2009/439107. Epub 2009 Jun 29. PubMed PMID:19587822; PubMed Central PMCID: PMC2705765. See more on PubMed
  • Pamuk GE, Demir M, Harmandar F, Yesil Y, Turgut B, Vural O. Leptin andresistin levels in serum of patients with hematologic malignancies: correlationwith clinical characteristics. Exp Oncol. 2006 Sep;28(3):241-4. PubMed PMID:17080020. See more on PubMed
  • Paul G, Schäffler A, Neumeier M, Fürst A, Bataillle F, Buechler C,Müller-Ladner U, Schölmerich J, Rogler G, Herfarth H. Profiling adipocytokinesecretion from creeping fat in Crohn's disease. Inflamm Bowel Dis. 2006Jun;12(6):471-7. PubMed PMID: 16775490. See more on PubMed
  • Petzel M, Stejskal D, Jedelsky L, Kadalova L, Safarcik K. The influence ofestradiole and tibolone administration on leptin levels in women with surgically induced menopause. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2008Jun;152(1):101-5. PubMed PMID: 18795083. See more on PubMed
  • Pilz S, Horejsi R, Möller R, Almer G, Scharnagl H, Stojakovic T, Dimitrova R, Weihrauch G, Borkenstein M, Maerz W, Schauenstein K, Mangge H. Earlyatherosclerosis in obese juveniles is associated with low serum levels ofadiponectin. J Clin Endocrinol Metab. 2005 Aug;90(8):4792-6. Epub 2005 May 31.PubMed PMID: 15928248. See more on PubMed
  • Pourghassem Gargari B, Houjeghani S, Farzadi L, Houjeghani S, Safaeiyan A.Relationship between Serum Leptin, Ghrelin and Dietary Macronutrients in Womenwith Polycystic Ovary Syndrome. Int J Fertil Steril. 2015 Oct-Dec;9(3):313-21.Epub 2015 Oct 31. PubMed PMID: 26644854; PubMed Central PMCID: PMC4671384. See more on PubMed
  • Puurunen VP, Lepojärvi ES, Piira OP, Hedberg P, Junttila MJ, Ukkola O, HuikuriHV. High plasma leptin levels are associated with impaired diastolic function in patients with coronary artery disease. Peptides. 2016 Oct;84:17-21. doi:10.1016/j.peptides.2016.08.002. Epub 2016 Aug 11. PubMed PMID: 27524739. See more on PubMed
  • Ripollés Piquer B, Nazih H, Bourreille A, Segain JP, Huvelin JM, Galmiche JP, Bard JM. Altered lipid, apolipoprotein, and lipoprotein profiles in inflammatory bowel disease: consequences on the cholesterol efflux capacity of serum usingFu5AH cell system. Metabolism. 2006 Jul;55(7):980-8. PubMed PMID: 16784973. See more on PubMed
  • Risch L, Saely C, Hoefle G, Rein P, Langer P, Gouya G, Marte T, Aczel S,Drexel H. Relationship between glomerular filtration rate and the adipokinesadiponectin, resistin and leptin in coronary patients with predominantly normalor mildly impaired renal function. Clin Chim Acta. 2007 Feb;376(1-2):108-13. Epub2006 Jul 29. PubMed PMID: 16956602. See more on PubMed
  • Rozmilowska I, Czyzewski D, Mazur B, Adamczyk-Sowa M. What is the role ofadipokines in myasthenia gravis? Ther Clin Risk Manag. 2018 Aug 28;14:1515-1525. doi: 10.2147/TCRM.S163966. eCollection 2018. PubMed PMID: 30214215; PubMedCentral PMCID: PMC6118871. See more on PubMed
  • Rubino E, Vacca A, Govone F, Gai A, Boschi S, Zucca M, De Martino P, GentileS, Pinessi L, Rainero I. Investigating the role of adipokines in chronicmigraine. Cephalalgia. 2017 Oct;37(11):1067-1073. doi: 10.1177/0333102416665871. Epub 2016 Aug 22. PubMed PMID: 27553954. See more on PubMed
  • Ruffingshofer D, Endemann M, Arbeiter K, Bidmon B, Mueller T, Herkner K,Aufricht C. Induction of heat shock protein 72 in mesothelial cells exposed toperitoneal dialysate effluent. Perit Dial Int. 2003 Jan-Feb;23(1):74-7. PubMedPMID: 12691510. See more on PubMed
  • Sáinz N, Rodríguez A, Catalán V, Becerril S, Ramírez B, Gómez-Ambrosi J,Frühbeck G. Leptin administration favors muscle mass accretion by decreasingFoxO3a and increasing PGC-1alpha in ob/ob mice. PLoS One. 2009 Sep 4;4(9):e6808. doi: 10.1371/journal.pone.0006808. PubMed PMID: 19730740; PubMed Central PMCID:PMC2733298. See more on PubMed
  • Seidel M, King JA, Ritschel F, Boehm I, Geisler D, Bernardoni F, Beck M,Pauligk S, Biemann R, Strobel A, Goschke T, Walter H, Roessner V, Ehrlich S.Processing and regulation of negative emotions in anorexia nervosa: An fMRIstudy. Neuroimage Clin. 2017 Dec 24;18:1-8. doi: 10.1016/j.nicl.2017.12.035.eCollection 2018. PubMed PMID: 29321971; PubMed Central PMCID: PMC5756056. See more on PubMed
  • Semnani S, Roshandel G, Keshtkar A, Najafi L, Amiriani T, Farajollahi M,Moradi A, Joshaghani H. Serum leptin levels and irritable bowel syndrome: a newhypothesis. J Clin Gastroenterol. 2009 Oct;43(9):826-30. doi:10.1097/MCG.0b013e3181986900. PubMed PMID: 19398923. See more on PubMed
  • Šenolt L, Kuklová M, Cerezo LA, Hulejová H, Filková M, Bošanská L, Pecha O,Pavelka K, Haluzík M, Vencovský J. Adipokine profile is modulated in subcutaneousadipose tissue by TNFα inhibitors in patients with rheumatoid arthritis. AnnRheum Dis. 2011 Nov;70(11):2054-6. doi: 10.1136/ard.2011.152603. Epub 2011 May27. PubMed PMID: 21622768. See more on PubMed
  • Schäffler A, Landfried K, Völk M, Fürst A, Büchler C, Schölmerich J, Herfarth H. Potential of adipocytokines in predicting peripancreatic necrosis and severityin acute pancreatitis: pilot study. J Gastroenterol Hepatol. 2007Mar;22(3):326-34. PubMed PMID: 17295762. See more on PubMed
  • Silha JV, Nyomba BL, Leslie WD, Murphy LJ. Ethnicity, insulin resistance, and inflammatory adipokines in women at high and low risk for vascular disease.Diabetes Care. 2007 Feb;30(2):286-91. PubMed PMID: 17259496. See more on PubMed
  • Stejskal D, Adamovská S, Bartek J, Juráková R, Prosková J. Resistin -concentrations in persons with type 2 diabetes mellitus and in individuals withacute inflammatory disease. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2003 Nov;147(1):63-9. PubMed PMID: 15034607. See more on PubMed
  • Stejskal D, Růzicka V, Adamovská S, Juráková R, Prosková J, Jedelský L, BartekJ. Adiponectin concentrations as a criterion of metabolic control in persons withtype 2 diabetes mellitus? Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub.2003 Dec;147(2):167-72. PubMed PMID: 15037898. See more on PubMed
  • Stejskal D, Stejskal P, Růzicka V, Jedelský L, Horalík D, Kalina M, Bartek J. [Leptinaemia in the Czech population]. Vnitr Lek. 1999 Mar;45(3):139-47. Czech.PubMed PMID: 15641235. See more on PubMed
  • Szczepankiewicz D, Sobkowiak P, Narożna B, Wojsyk-Banaszak I, Bręborowicz A,Szczepankiewicz A. Leptin gene polymorphism affects leptin level in childhoodasthma. World J Pediatr. 2018 Dec;14(6):601-606. doi: 10.1007/s12519-018-0182-2. Epub 2018 Sep 10. PubMed PMID: 30203371; PubMed Central PMCID: PMC6208747. See more on PubMed
  • Teplan V, Schück O, Stollová M, Vítko S. Obesity and hyperhomocysteinaemiaafter kidney transplantation. Nephrol Dial Transplant. 2003 Jul;18 Suppl 5:v71-3.PubMed PMID: 12817077. See more on PubMed
  • Trachta P, Dostálová I, Haluzíková D, Kasalický M, Kaválková P, Drápalová J,Urbanová M, Lacinová Z, Mráz M, Haluzík M. Laparoscopic sleeve gastrectomyameliorates mRNA expression of inflammation-related genes in subcutaneous adiposetissue but not in peripheral monocytes of obese patients. Mol Cell Endocrinol.2014 Mar 5;383(1-2):96-102. doi: 10.1016/j.mce.2013.11.013. Epub 2013 Nov 27.PubMed PMID: 24291610. See more on PubMed
  • Tsaroucha A, Daniil Z, Malli F, Georgoulias P, Minas M, Kostikas K, BargiotaA, Zintzaras E, Gourgoulianis KI. Leptin, adiponectin, and ghrelin levels infemale patients with asthma during stable and exacerbation periods. J Asthma.2013 Mar;50(2):188-97. doi: 10.3109/02770903.2012.747101. Epub 2012 Dec 21.PubMed PMID: 23259727. See more on PubMed
  • van Dielen FM, van 't Veer C, Buurman WA, Greve JW. Leptin and soluble leptin receptor levels in obese and weight-losing individuals. J Clin Endocrinol Metab. 2002 Apr;87(4):1708-16. PubMed PMID: 11932305. See more on PubMed
  • van Dielen FM, van't Veer C, Schols AM, Soeters PB, Buurman WA, Greve JW.Increased leptin concentrations correlate with increased concentrations ofinflammatory markers in morbidly obese individuals. Int J Obes Relat MetabDisord. 2001 Dec;25(12):1759-66. PubMed PMID: 11781755. See more on PubMed
  • Vitkova M, Klimcakova E, Kovacikova M, Valle C, Moro C, Polak J, Hanacek J,Capel F, Viguerie N, Richterova B, Bajzova M, Hejnova J, Stich V, Langin D.Plasma levels and adipose tissue messenger ribonucleic acid expression ofretinol-binding protein 4 are reduced during calorie restriction in obesesubjects but are not related to diet-induced changes in insulin sensitivity. JClin Endocrinol Metab. 2007 Jun;92(6):2330-5. Epub 2007 Apr 3. PubMed PMID:17405846. See more on PubMed
  • Welt CK, Schneyer AL, Heist K, Mantzoros CS. Leptin and soluble leptinreceptor in follicular fluid. J Assist Reprod Genet. 2003 Dec;20(12):495-501.PubMed PMID: 15035548; PubMed Central PMCID: PMC3455309. See more on PubMed
  • Wiecek M, Szymura J, Maciejczyk M, Kantorowicz M, Szygula Z. Acute AnaerobicExercise Affects the Secretion of Asprosin, Irisin, and Other Cytokines - AComparison Between Sexes. Front Physiol. 2018 Dec 10;9:1782. doi:10.3389/fphys.2018.01782. eCollection 2018. PubMed PMID: 30618797; PubMed CentralPMCID: PMC6295572. See more on PubMed
  • Wilson R, Willis J, Gearry RB, Hughes A, Lawley B, Skidmore P, Frampton C,Fleming E, Anderson A, Jones L, Tannock GW, Carr AC. SunGold KiwifruitSupplementation of Individuals with Prediabetes Alters Gut Microbiota andImproves Vitamin C Status, Anthropometric and Clinical Markers. Nutrients. 2018Jul 12;10(7). pii: E895. doi: 10.3390/nu10070895. PubMed PMID: 30002355; PubMedCentral PMCID: PMC6073280. See more on PubMed
  • Wójcik K, Jabłonowska E, Omulecka A, Piekarska A. Insulin resistance,adipokine profile and hepatic expression of SOCS-3 gene in chronic hepatitis C.World J Gastroenterol. 2014 Aug 14;20(30):10449-56. doi:10.3748/wjg.v20.i30.10449. PubMed PMID: 25132761; PubMed Central PMCID:PMC4130852. See more on PubMed
  • Woo YC, Lee CH, Fong CH, Xu A, Tso AW, Cheung BM, Lam KS. Serum fibroblastgrowth factor 21 is a superior biomarker to other adipokines in predictingincident diabetes. Clin Endocrinol (Oxf). 2017 Jan;86(1):37-43. doi:10.1111/cen.13229. Epub 2016 Sep 29. PubMed PMID: 27611701. See more on PubMed
  • Saeed Z, Haleh S, Afsaneh M, Soheila A, Amir Hassan Z, Farah I, Banafsheh T,Elham SS, Narges MB, Mahmood JT. Serum leptin levels in women with immunological recurrent abortion. J Reprod Infertil. 2010 Apr;11(1):47-52. PubMed PMID:23926480; PubMed Central PMCID: PMC3719276. See more on PubMed
  • Chen LW, Chen FP, Hsieh CW, Kuo SF, Chien RN. Analysis of the associationsamong Helicobacter pylori infection, adiponectin, leptin, and 10-year fracturerisk using the fracture risk assessment tool: A cross-sectional community-basedstudy. PLoS One. 2017 Apr 7;12(4):e0175365. doi: 10.1371/journal.pone.0175365.eCollection 2017. PubMed PMID: 28388631; PubMed Central PMCID: PMC5384782. See more on PubMed
  • Wilson R, Willis J, Gearry R, Skidmore P, Fleming E, Frampton C, Carr A.Inadequate Vitamin C Status in Prediabetes and Type 2 Diabetes Mellitus:Associations with Glycaemic Control, Obesity, and Smoking. Nutrients. 2017 Sep9;9(9). pii: E997. doi: 10.3390/nu9090997. PubMed PMID: 28891932; PubMed Central PMCID: PMC5622757. See more on PubMed
  • Szewczyk-Golec K, Rajewski P, Gackowski M, Mila-Kierzenkowska C, Wesołowski R,Sutkowy P, Pawłowska M, Woźniak A. Melatonin Supplementation Lowers OxidativeStress and Regulates Adipokines in Obese Patients on a Calorie-Restricted Diet.Oxid Med Cell Longev. 2017;2017:8494107. doi: 10.1155/2017/8494107. Epub 2017 Sep21. PubMed PMID: 29142618; PubMed Central PMCID: PMC5632922. See more on PubMed
  • Mitanchez D, Jacqueminet S, Nizard J, Tanguy ML, Ciangura C, Lacorte JM, DeCarne C, Foix L'Hélias L, Chavatte-Palmer P, Charles MA, Dommergues M. Effect of maternal obesity on birthweight and neonatal fat mass: A prospective clinicaltrial. PLoS One. 2017 Jul 27;12(7):e0181307. doi: 10.1371/journal.pone.0181307.eCollection 2017. PubMed PMID: 28750045; PubMed Central PMCID: PMC5531500. See more on PubMed
  • Namavar Jahromi B, Dabaghmanesh MH, Parsanezhad ME, Fatehpoor F. Associationof leptin and insulin resistance in PCOS: A case-controlled study. Int J ReprodBiomed (Yazd). 2017 Jul;15(7):423-428. PubMed PMID: 29177243; PubMed CentralPMCID: PMC5601933. See more on PubMed
  • Behrouz V, Jazayeri S, Aryaeian N, Zahedi MJ, Hosseini F. Effects of Probioticand Prebiotic Supplementation on Leptin, Adiponectin, and Glycemic Parameters in Non-alcoholic Fatty Liver Disease: A Randomized Clinical Trial. Middle East J DigDis. 2017 Jul;9(3):150-157. doi: 10.15171/mejdd.2017.66. PubMed PMID: 28894517;PubMed Central PMCID: PMC5585907. See more on PubMed
  • Kratochvilova H, Lacinova Z, Klouckova J, Kavalkova P, Cinkajzlova A, Trachta P, Krizova J, Benes M, Dolezalova K, Fried M, Vlasakova Z, Pelikanova T, SpicakJ, Mraz M, Haluzik M. Neudesin in obesity and type 2 diabetes mellitus: theeffect of acute fasting and weight reducing interventions. Diabetes Metab SyndrObes. 2019 Mar 28;12:423-430. doi: 10.2147/DMSO.S193259. eCollection 2019. PubMedPMID: 30992678; PubMed Central PMCID: PMC6445223. See more on PubMed
  • Adamska-Patruno E, Ostrowska L, Goscik J, Fiedorczuk J, Moroz M, Kretowski A, Gorska M. The Differences in Postprandial Serum Concentrations of Peptides ThatRegulate Satiety/Hunger and Metabolism after Various Meal Intake, in Men withNormal vs. Excessive BMI. Nutrients. 2019 Feb 26;11(3). pii: E493. doi:10.3390/nu11030493. PubMed PMID: 30813625; PubMed Central PMCID: PMC6471764. See more on PubMed
  • Saeidi A, Jabbour G, Ahmadian M, Abbassi-Daloii A, Malekian F, Hackney AC,Saedmocheshi S, Basati G, Ben Abderrahman A, Zouhal H. Independent and CombinedEffects of Antioxidant Supplementation and Circuit Resistance Training onSelected Adipokines in Postmenopausal Women. Front Physiol. 2019 Apr 26;10:484.doi: 10.3389/fphys.2019.00484. eCollection 2019. PubMed PMID: 31105587; PubMedCentral PMCID: PMC6499001. See more on PubMed
Summary References (20)

References to Leptin

  • Auwerx J, Staels B. Leptin (Review article). The Lancet . 13, 737 (1998);
  • Blum WF, Englaro P, Hanitsch S, Juul A, Hertel NT, Muller J, Skakkebaek NE, Heiman ML, Birkett M, Attanasio AM, Kiess W, Rascher W. Plasma leptin levels in healthy children and adolescents: dependence on body mass index, body fat mass, gender, pubertal stage, and testosterone. J Clin Endocrinol Metab. 1997 Sep;82 (9):2904-10
  • Chehab FF, Mounzih K, Lu R, Lim ME. Early onset of reproductive function in normal female mice treated with leptin. Science. 1997 Jan 3;275 (5296):88-90
  • Clement K, Vaisse C, Lahlou N, Cabrol S, Pelloux V, Cassuto D, Gourmelen M, Dina C, Chambaz J, Lacorte JM, Basdevant A, Bougneres P, Lebouc Y, Froguel P, Guy-Grand B. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature. 1998 Mar 26;392 (6674):398-401
  • Cohen B, Novick D, Rubinstein M. Modulation of insulin activities by leptin. Science. 1996 Nov 15;274 (5290):1185-8
  • Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, Ohannesian JP, Marco CC, McKee LJ, Bauer TL, et al. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med. 1996 Feb 1;334 (5):292-5
  • Friedman JM, Halaas JL. Leptin and the regulation of body weight in mammals. Nature. 1998 Oct 22;395 (6704):763-70
  • Halaas JL, Gajiwala KS, Maffei M, Cohen SL, Chait BT, Rabinowitz D, Lallone RL, Burley SK, Friedman JM. Weight-reducing effects of the plasma protein encoded by the obese gene. Science. 1995 Jul 28;269 (5223):543-6
  • Harigaya A, Nagashima K, Nako Y, Morikawa A. Relationship between concentration of serum leptin and fetal growth. J Clin Endocrinol Metab. 1997 Oct;82 (10):3281-4
  • Lonnqvist F, Arner P, Nordfors L, Schalling M. Overexpression of the obese (ob) gene in adipose tissue of human obese subjects. Nat Med. 1995 Sep;1 (9):950-3
  • Maffei M, Halaas J, Ravussin E, Pratley RE, Lee GH, Zhang Y, Fei H, Kim S, Lallone R, Ranganathan S, et al. Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med. 1995 Nov;1 (11):1155-61
  • Montague CT, Farooqi IS, Whitehead JP, Soos MA, Rau H, Wareham NJ, Sewter CP, Digby JE, Mohammed SN, Hurst JA, Cheetham CH, Earley AR, Barnett AH, Prins JB, O'Rahilly S. Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature. 1997 Jun 26;387 (6636):903-8
  • Pelleymounter MA, Cullen MJ, Baker MB, Hecht R, Winters D, Boone T, Collins F. Effects of the obese gene product on body weight regulation in ob/ob mice. Science. 1995 Jul 28;269 (5223):540-3
  • Ricci MR, Lee MJ, Russell CD, Wang Y, Sullivan S, Schneider SH, Brolin RE, Fried SK. Isoproterenol decreases leptin release from rat and human adipose tissue through posttranscriptional mechanisms. Am J Physiol Endocrinol Metab. 2005 Apr;288 (4):E798-804
  • Schubring C, Prohaska F, Prohaska A, Englaro P, Blum W, Siebler T, Kratzsch J, Kiess W. Leptin concentrations in maternal serum and amniotic fluid during the second trimenon: differential relation to fetal gender and maternal morphometry. Eur J Obstet Gynecol Reprod Bi. 1999 Oct;86 (2):151-7
  • Spiegelman BM, Flier JS. Adipogenesis and obesity: rounding out the big picture. Cell. 1996 Nov 1;87 (3):377-89
  • Tartaglia LA. The leptin receptor. J Biol Chem. 1997 Mar 7;272 (10):6093-6
  • Tritos NA, Mantzoros CS. Leptin: its role in obesity and beyond. Diabetologia. 1997 Dec;40 (12):1371-9
  • Zhang F, Basinski MB, Beals JM, Briggs SL, Churgay LM, Clawson DK, DiMarchi RD, Furman TC, Hale JE, Hsiung HM, Schoner BE, Smith DP, Zhang XY, Wery JP, Schevitz RW. Crystal structure of the obese protein leptin-E100. Nature. 1997 May 8;387 (6629):206-9
  • Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature. 1994 Dec 1;372 (6505):425-32
Related Products Docs