Type
Monoclonal Antibody
Applications
Western blotting, Immunohistochemistry, Flow cytometry
Source of Antigen
Human placenta
Hosts
Mouse
Isotype
IgG1, kappa
Preparation
The antibody is a mouse monoclonal antibody against native human mannose receptor purified from human placenta.
Species Reactivity
Human. Not yet tested in other species.
Formulation
Each vial contains mAb MR 15-2-2 in PBS containing 0.1% w/v BSA. Bulk delivery in other formulations on request.
Shipping
On dry ice. Upon receipt, store the product at the temperature recommended below.
Storage/Expiration
Store at -20°C
Note
Products are for Research Use only.
Research topic
Immune Response, Infection and Inflammation
Summary
Macrophage mannose receptor (MMR) or CD206 is
an endocytic and phagocytic receptor that recognizes
appropriately configured carbohydrate ligands in
target molecules.
CD206 is expressed mainly in mature tissue
macrophages and immature dendritic cells, and is
thought to play a role in both the innate and adaptive
immune responses of the host. The expression of
CD206 is affected, among other factors, by
pathogens, cytokines and immunoglobulin receptors.
While the protein sequence information predicts
CD206 to weigh around 166kDa, the cleavage of the
signal peptide gives rise to an immature 154 kDa
protein before undergoing N- and O-linked
glycosylation to result in a 162 kDa mature molecule
in macrophages. Secreted forms resulting from the
proteolytic cleavage of the extracellular domain have
also been observed. The binding to mannose is
calcium dependent.
