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Manufactured by BioVendor

Mouse Gasdermin D ELISA

  • Regulatory status:RUO
  • Type:Sandwich ELISA, Biotin-labelled antibody
  • Other names:DFNA5L, GSDMDC1
  • Species:Mouse
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Cat. No. Size Price


New RAG025R 96 wells (1 kit)
PubMed Product Details
Technical Data

Type

Sandwich ELISA, Biotin-labelled antibody

Applications

Cell lysate, Cell culture supernatant

Sample Requirements

50µl/well

Storage/Expiration

Store the complete kit at 2–8°C. Under these conditions, the kit is stable until the expiration date (see label on the box).

Calibration Range

15.6 - 1000 pg/ml

Limit of Detection

14 pg/ml

Intra-assay (Within-Run)

n = 8
CV = 7.2%

Inter-assay (Run-to-Run)

n = 5
CV = 8.6%

Summary

Features

It is intended for research use only

The total assay time is less than 4 hours

The kit measures mouse gasdermin D in cell cuture supernatant and cell lysate

Assay format is 96 wells

Components of the kit are provided ready to use, concentrated or dried

Research topic

Immune Response, Infection and Inflammation

Summary

Gasdermin D forming pores regulate the non-conventional secretion of cytokines such as IL-1β, in response to cytosolic LPS and other activators of the inflammasome. Neutrophil extrusion of neutrophil extracellular traps (NETs) and concomitant cell death (NETosis), a particular neutrophil defense against pathogens, are dependent on Gasdermin D. Gasdermin D-mediated pyroptosis is regulated at the level of lipid peroxidation and seems to be a key effector in the LPS-induced lethal sepsis.

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