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sCD152/CTLA-4 Human ELISA

  • Regulatory status:RUO
  • Other names:Cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-associated antigen 4, CD152 antigen, Cytotoxic T lymphocyte antigen 4
  • Species:Human
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Cat. No. Size Price


RAF088R 96 wells (1 kit)
PubMed Product Details
Technical Data

Applications

Serum, Plasma-EDTA, Plasma-Heparin, Amniotic fluid, Cell culture supernatant

Sample Requirements

10 µl/well

Storage/Expiration

Store the complete kit at 2–8°C. Under these conditions, the kit is stable until the expiration date (see label on the box).

Calibration Curve

Calibration Range

0.16–10 ng/ml

Limit of Detection

0.13 ng/ml

Intra-assay (Within-Run)

CV = 4.8%

Inter-assay (Run-to-Run)

CV = 10.4%

Spiking Recovery

78,00%

Dilutation Linearity

110,00%

Summary

Research topic

Cell surface proteins (sCD), Transplantation

Summary

Cytotoxic T lymphocyte associated gene –4 (CTLA-4) was initially described as a classical type I glycoprotein on the surface of activated T-cells (1). CTLA-4 is a member of the Ig gene superfamily and along with its homologue, CD28, is a B7 binding protein. There is evidence that CTLA-4 is a negative regulator of T-cell activation, ligation of CTLA-4 on the T-cell surface initiates a series of biochemical events that attenuate an ongoing immune response .
CTLA-4 knock out mice demonstrate profound polyclonal lymphoproliferative disoders that infiltrate most major organ systems and the animals die a few weeks after birth. The animals have increased levels of IgG which illustrates the role of CTLA-4 on humoral immune responses as well.
A role for CTLA-4 in autoimmune disease is suggested by the observations that blockade of B7/CTLA-4 interaction exacerbates animal models of autoimmune disease such as experimental autoimmune encephalomyelitis and diabetes. A search for genetic markers that segregate with Graves‘ disease revealed an association with CTLA-4 polymorphisms. CTLA-4 is further more closely linked to autoimmune thyroid disease (ATD). A native soluble form of CTLA-4 has been described to be present in human serum . A correlation of circulating CTLA-4 and ATD has been shown.

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