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Urine BETA CrossLaps® ELISA (β-CTX-I)

  • Regulatory status:RUO
  • Type:Sandwich ELISA, HRP-labelled antibody
  • Other names:C-terminal telopeptide I, carboxy-terminal collagen I crosslinks
  • Species:Human
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Cat. No. Size Price


AC-05F1 96 wells
PubMed Product Details
Technical Data

Type

Sandwich ELISA, HRP-labelled antibody

Description

The Urine BETA CrossLaps® (CTX-I) ELISA is an enzyme immunological test for the quantification of degradation products of C-terminal telopeptides of Type-I collagen in human urine. The Urine BETA CrossLaps® (CTX-I) ELISA assay is intended for in vitro diagnostic use as an indication of human bone resorption as an aid in:

  1. Monitoring bone resorption changes of anti-resorptive therapies in postmenopausal women:
  • Hormone Replacement Therapies (HRT) with hormones and hormone-like drugs
  • Bisphosphonate therapies
  1. Predicting skeletal response (Bone Mineral Density) in postmenopausal women undergoing anti-resorptive therapies
  • Hormone Replacement Therapies (HRT) with hormones and hormone-like drugs
  • Bisphosphonate therapies

Scientific Description:

Type I collagen accounts for more than 90% of the organic matrix of bone and is synthesised primarily in bone. During renewal of the skeleton, type I collagen is degraded, and small peptide fragments are excreted into the urine. These fragments can be measured by the Urine BETA CrossLaps® (CTX-I) ELISA. The Urine BETA CrossLaps® (CTX-I) ELISA is based on two highly specific monoclonal antibodies against the amino acid sequence of EKAHD-β-GGR, where the aspartic acid residue (D) is β-isomerized. In order to obtain a specific signal in the Urine BETA CrossLaps®(CTX-I) ELISA, two chains of EKAHD-β-GGR must be cross-linked. Urine BETA CrossLaps® (CTX-I) ELISA demonstrates a high correlation to corresponding measurements of serum samples in the Serum CrossLaps® (CTX-I) ELISA.

Applications

Urine

Sample Requirements

10 μL Pre-diluted (1+3)

Storage/Expiration

Store the complete kit at 2-8°C. Under these conditions, the kit is stable until the expiration date (see label on the box).

Calibration Range

0-40.7 μg/L

Limit of Detection

0.80 μg/L CrossLaps

Summary

Features

  • Management of Postmenopausal Osteoporosis
  • Prediction of long-term skeletal response to anti-resorptive therapies, e.g. HRT, bisphosphonates
  • Increase in patient motivation and compliance
  • Assessment of Bone Resorption in Patients
  • With metabolic bone disease, e.g. hyperparathyroidism, Paget´s disease, osteodystrophy
  • Receiving prolonged glucocorticoid therapy
  • Easy to perform – one step incubation

Research topic

Bone and cartilage metabolism

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